Variations in ionospheric D-region recombination properties during increase of its X-ray heating induced by solar X-ray flare

In this paper we present an analysis of parameters describing the effective recombination processes in the upper ionospheric D-region in the period of its additional heating by the X-radiation emitted during a solar X-ray flare. We present a procedure for calculation of the effective recombination coefficient and electron loss rate in the period when the X-radiation flux detected by the GOES satellite in the wavelength domain between 0.1 and 0.8 nm increases. The developed procedure is based on observational data obtained in the low ionospheric monitoring by the very low/low frequency radio waves and it is related to the considered area and time period. The obtained expressions are applied to data for the very low frequency signal emitted in Germany and recorded in Serbia during the solar X-ray flare detected by the GOES-14 satellite on May 5, 2010

The impact of the global economic crisis on the economy of the Republic of Serbia

The global economic crisis has certainly had a significant negative impact on the economic situation in Serbia. However, it is wrong to relate all the financial difficulties of the Serbian economy to the global crisis, and an even greater mistake would be to hope that all its problems will be solved by the termination of the global economic crisis. Our economy is, we can say, in the decades-long decline. Its losses accumulated over the past seventeen years increased from 3.8 billion to 2,462 billion dinars, or 648 times. This paper aims to point out the bad financial and structural position of Serbian economy that constantly hampers the economic activity and causes the distortion of the companies' worth. Keeping this in mind, after the introductory discussion in the first section of this paper, we provide some elaboration on the interdependence of macroeconomic indicators and the performance of the economy. The second section presents macroeconomic environment in Serbia in the period of the analysis of the Serbian economy financial position. The third section highlights the fact that business losses and their accumulation affect the financial structure of the economy. The fourth and the fifth sections deal with the analysis of net working capital, which is an important tool for assessing the financial structure

Orthogonal Control of Neuronal Circuits and Behavior Using Photopharmacology

Over the last decades, photopharmacology has gone far beyond its proof-of-concept stage to become a bona fide approach to study neural systems in vivo. Indeed, photopharmacological control has expanded over a wide range of endogenous targets, such as receptors, ion channels, transporters, kinases, lipids, and DNA transcription processes. In this review, we provide an overview of the recent progresses in the in vivo photopharmacological control of neuronal circuits and behavior. In particular, the use of small aquatic animals for the in vivo screening of photopharmacological compounds, the recent advances in optical modulation of complex behaviors in mice, and the development of adjacent techniques for light and drug delivery in vivo are described

Augmented Reality and Intraoperative Navigation in Sinonasal Malignancies: A Preclinical Study

Objective: To report the first use of a novel projected augmented reality (AR) system in open sinonasal tumor resections in preclinical models and to compare the AR approach with an advanced intraoperative navigation (IN) system. Methods: Four tumor models were created. Five head and neck surgeons participated in the study performing virtual osteotomies. Unguided, AR, IN, and AR + IN simulations were performed. Statistical comparisons between approaches were obtained. Intratumoral cut rate was the main outcome. The groups were also compared in terms of percentage of intratumoral, close, adequate, and excessive distances from the tumor. Information on a wearable gaze tracker headset and NASA Task Load Index questionnaire results were analyzed as well. Results: A total of 335 cuts were simulated. Intratumoral cuts were observed in 20.7%, 9.4%, 1.2,% and 0% of the unguided, AR, IN, and AR + IN simulations, respectively (p < 0.0001). The AR was superior than the unguided approach in univariate and multivariate models. The percentage of time looking at the screen during the procedures was 55.5% for the unguided approaches and 0%, 78.5%, and 61.8% in AR, IN, and AR + IN, respectively (p < 0.001). The combined approach significantly reduced the screen time compared with the IN procedure alone. Conclusion: We reported the use of a novel AR system for oncological resections in open sinonasal approaches, with improved margin delineation compared with unguided techniques. AR improved the gaze-toggling drawback of IN. Further refinements of the AR system are needed before translating our experience to clinical practice

Projected cutting guides using an augmented reality system to improve surgical margins in maxillectomies: A preclinical study

Background: Positive margins have been reported up to 80% in advanced maxillary cancers. Intraoperative navigation (IN) aims to improve margins, but provides a two-dimensional view of a registered instrument without anticipating any cutting directions, and the information is displayed in monitors outside surgical field. Augmented Reality (AR) can delineate margins while addressing the gaze-toggling drawback of IN. In a preclinical setting, we implemented preoperative-planned osteotomies needed for maxillectomies and projected this information on the surgical field using AR. We aimed to improve negative margin rates while retaining the benefits of AR. Methods: Five maxillary tumor models were built. Five fellowship-trained surgeons completed virtual unguided and AR-guided maxillectomies. Comparisons in terms of intratumoral cuts, close, adequate, and excessive distances from the tumor were performed. Differences between “ideal” cutting-plan and the AR-guided virtual osteotomies was obtained. Workload questionnaires to evaluate the technology were completed. Results: 115 virtual osteotomies were analyzed. Intra-tumoral and “close” margins were lower for the AR-assisted osteotomies (0.0% vs 1.9% p < 0.0001 and 0.8% vs 7.9% p < 0.0001). Proportion of “adequate” margins were higher in the AR simulations (25.3% vs 18.6%, p = 0.018). The AR osteotomies had high similarity with the pre-planned with interclass correlation index close to 1 in “adequate” margins 0.893 (95% CI: 0.804–0.949). Workload scores were better for AR-guided simulations for the domains of mental demand, performance, effort and frustration. Conclusion: The projector-based AR method improved margin delineation, and preoperative planning was accurately translated to the simulations. Clinical translation will aim to consolidate our preclinical findings to improve outcomes