A Modified Direct Power Control Strategy Allowing the Connection of Three-Phase Inverters to the Grid Through LCL Filters

Abstract — This paper proposes a novel approach to adapt the conventional Direct Power Control (DPC) for high power applications with a third order LCL filter. The strong resonance present in the LCL filter is damped with additional effort in the system control. The application of DPC to the control of threephase Voltage Source Inverter (VSI) connected to the grid through a LCL filter has not yet been considered. An active damping strategy for the LCL filter together with harmonic rejection control is proposed over the conventional DPC. The steady state as well as the dynamic performance of the proposed system is presented by means of the simulation results and compared with the conventional approach

Folding of VemP into translation-arresting secondary structure is driven by the ribosome exit tunnel

The ribosome is a fundamental biomolecular complex that synthesizes proteins in cells. Nascent proteins emerge from the ribosome through a tunnel, where they may interact with the tunnel walls or small molecules such as antibiotics. These interactions can cause translational arrest with notable physiological consequences. Here, we studied the arrest caused by the regulatory peptide VemP, which is known to form alpha-helices inside the ribosome tunnel near the peptidyl transferase center under specific conditions. We used all-atom molecular dynamics simulations of the entire ribosome and circular dichroism spectroscopy to study the driving forces of helix formation and how VemP causes the translational arrest. To that aim, we compared VemP dynamics in the ribosome tunnel with its dynamics in solution. We show that the VemP peptide has a low helical propensity in water and that the propensity is higher in mixtures of water and trifluorethanol. We propose that helix formation within the ribosome is driven by the interactions of VemP with the tunnel and that a part of VemP acts as an anchor. This anchor might slow down VemP progression through the tunnel enabling alpha-helix formation, which causes the elongation arrest

Reducing greenhouse gas emissions in Czechoslovakia

In this paper are presented important findings on the potential for energy conservation and carbon emissions reduction over the coming decades in Czechoslovakia. The authors describe the state of the energy use in Czechoslovakia today and the measures required to transform its energy system to a market-based economy oriented towards the environmental goal of decreased energy intensity. This work furthers our understanding of the need for energy efficiency in the newly forming market economies of East and Central Europe. This paper is part of a series of country studies sponsored by the Global Climate Division of the Office of Policy, Planning, and Evaluation, United States Environmental Protection Agency (EPA). We have completed similar studies in Canada, the former Soviet Union, France, Hungary, Italy, Japan, Poland the United Kingdom, and the United States. Research is currently underway or planned in Bulgaria, Romania, and Ukraine

Extended states in 1D lattices: application to quasiperiodic copper-mean chain

The question of the conditions under which 1D systems support extended electronic eigenstates is addressed in a very general context. Using real space renormalisation group arguments we discuss the precise criteria for determining the entire spertrum of extended eigenstates and the corresponding eigenfunctions in disordered as well as quasiperiodic systems. For purposes of illustration we calculate a few selected eigenvalues and the corresponding extended eigenfunctions for the quasiperiodic copper-mean chain. So far, for the infinite copper-mean chain, only a single energy has been numerically shown to support an extended eigenstate [ You et al. (1991)] : we show analytically that there is in fact an infinite number of extended eigenstates in this lattice which form fragmented minibands.Comment: 10 pages + 2 figures available on request; LaTeX version 2.0

The Error and Repair Catastrophes: A Two-Dimensional Phase Diagram in the Quasispecies Model

This paper develops a two gene, single fitness peak model for determining the equilibrium distribution of genotypes in a unicellular population which is capable of genetic damage repair. The first gene, denoted by $\sigma_{via}$, yields a viable organism with first order growth rate constant $k > 1$ if it is equal to some target ``master'' sequence $\sigma_{via, 0}$. The second gene, denoted by $\sigma_{rep}$, yields an organism capable of genetic repair if it is equal to some target ``master'' sequence $\sigma_{rep, 0}$. This model is analytically solvable in the limit of infinite sequence length, and gives an equilibrium distribution which depends on \mu \equiv L\eps , the product of sequence length and per base pair replication error probability, and \eps_r , the probability of repair failure per base pair. The equilibrium distribution is shown to exist in one of three possible ``phases.'' In the first phase, the population is localized about the viability and repairing master sequences. As \eps_r exceeds the fraction of deleterious mutations, the population undergoes a ``repair'' catastrophe, in which the equilibrium distribution is still localized about the viability master sequence, but is spread ergodically over the sequence subspace defined by the repair gene. Below the repair catastrophe, the distribution undergoes the error catastrophe when $\mu$ exceeds \ln k/\eps_r , while above the repair catastrophe, the distribution undergoes the error catastrophe when $\mu$ exceeds $\ln k/f_{del}$, where $f_{del}$ denotes the fraction of deleterious mutations.Comment: 14 pages, 3 figures. Submitted to Physical Review

Can Remote Sensing Technologies Capture the Extreme Precipitation Event and Its Cascading Hydrological Response? A Case Study of Hurricane Harvey Using EF5 Modeling Framework

A new generation of precipitation measurement products has emerged, and their performances have gained much attention from the scientific community, such as the Multi-Radar Multi-Sensor system (MRMS) from the National Severe Storm Laboratory (NSSL) and the Global Precipitation Measurement Mission (GPM) from the National Aeronautics and Space Administration (NASA). This study statistically evaluated the MRMS and GPM products and investigated their cascading hydrological response in August of 2017, when Hurricane Harvey brought historical and record-breaking precipitation to the Gulf Coast (>1500 mm), causing 107 fatalities along with about USD 125 billion worth of damage. Rain-gauge observations from Harris County Flood Control District (HCFCD) and stream-gauge measurements by the United States Geological Survey (USGS) were used as ground truths to evaluate MRMS, GPM and National Centers for Environmental Prediction (NCEP) gauge-only data by using statistical metrics and hydrological simulations using the Ensemble Framework for Flash Flooding Forecast (EF5) model. The results indicate that remote sensing technologies can accurately detect and estimate the unprecedented precipitation event with their near-real-time products, and all precipitation products produced good hydrological simulations, where the Nash–Sutcliff model efficiency coefficients (NSCE) were close to 0.9 for both the MRMS and GPM products. With the timeliness and seamless coverage of MRMS and GPM, the study also demonstrated the capability and efficiency of the EF5 framework for flash flood modeling over the United States and potentially additional international domains.This study is partially funded by University of Oklahoma and also based upon work supported by the National Science Foundation under Grant No. 1545874. Open Access fees paid for in whole or in part by the University of Oklahoma Libraries.Ye

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models.

Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but traditionally intractable drug target. Here we provide genetic and pharmacological evidence that in preclinical models ACC is required to maintain the de novo fatty acid synthesis needed for growth and viability of non-small-cell lung cancer (NSCLC) cells. We describe the ability of ND-646-an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 that prevents ACC subunit dimerization-to suppress fatty acid synthesis in vitro and in vivo. Chronic ND-646 treatment of xenograft and genetically engineered mouse models of NSCLC inhibited tumor growth. When administered as a single agent or in combination with the standard-of-care drug carboplatin, ND-646 markedly suppressed lung tumor growth in the Kras;Trp53-/- (also known as KRAS p53) and Kras;Stk11-/- (also known as KRAS Lkb1) mouse models of NSCLC. These findings demonstrate that ACC mediates a metabolic liability of NSCLC and that ACC inhibition by ND-646 is detrimental to NSCLC growth, supporting further examination of the use of ACC inhibitors in oncology