Asymptotic analysis of oscillatory integrals via the Newton polyhedra of the phase and the amplitude

The asymptotic behavior at infinity of oscillatory integrals is in detail investigated by using the Newton polyhedra of the phase and the amplitude. We are especially interested in the case that the amplitude has a zero at a critical point of the phase. The properties of poles of local zeta functions, which are closely related to the behavior of oscillatory integrals, are also studied under the associated situation.Comment: 36 page

Mediating the East Asian Era of the Olympic Games (2018–2022):Introduction to the Special Issue

In the span of four years from 2018 to 2022, three consecutive Olympic Games were held in East Asia – namely PyeongChang 2018 in South Korea, Tokyo 2020 in Japan and Beijing 2022 in China. Given the geographic concentration of global multi-sports mega-events in the Far East, this period has been referred to as the ‘East Asian era’ of the Olympic Games. This introduction to the special issue outlines two major themes of the changes during the East Asian era: (1) the shift of economic and geopolitical power from the West to the East; and (2) the changes and challenges offered by the Olympic Agenda 2020 reforms and theCOVID-19 pandemic within East Asia. After that, each contribution will be introduced and briefly described. Overall, by collecting contributions focusing on the 2018–2022 Olympic Games, this special issue critically analyses the state of play in the formations of dominant and emerging discourses during the East Asia era and offers its implications for a broader understanding of the continuity and changes to the economic, political, social, cultural and ecological dimensions of the Olympic Movement

Personal tempo and pattern formation in polyrhythmic tapping

Personal tempos in our rhythmic movements have been studied with various tasks. However, no studies have examined the personal tempo in bimanual coordination with interference between the right and left hand movements, because the previous studies used auditory or visual stimuli in acquisition. For the same reason, a formation of the bimanual coordination pattern could not be examined. Therefore, the purposes of this study were to compare personal tempos produced by a single-rhythmic tapping and a 3 : 2 polyrhythmic tapping, and to clarify a mechanism of the 3 : 2 polyrhythmic pattern formation from a viewpoint of entrainment. Intertap intervals (ITIs) of each rhythmic tapping by ten subjects were analyzed. Results showed that the single-rhythmic tapping produced ITIs which were similar to ITIs of 3-beat sequence in the 3 : 2 polyrhythmic tapping. This suggests that there exist consistency between the single-rhythmic tapping and polyrhythmic tapping with a personal tempo. Another result showed that 2 : 1 and 1 : 1 patterns were emerged before the formation of 3 : 2 pattern. Such a shift is expressed in Farey tree that shows frequency rations at entrainment. We found that the complicated pattern was formed through the formation of more stable patterns formed by entrainment

Spectropolarimetric Study on Circumstellar Structure of Microquasar LS I +61deg 303

We present optical linear spectropolarimetry of the microquasar LS I +61$^{\circ}$ 303. The continuum emission is mildly polarized (up to 1.3 %) and shows almost no temporal change. We find a distinct change of polarization across the H$\alpha$ emission line, indicating the existence of polarization component intrinsic to the microquasar. We estimate the interstellar polarization (ISP) component from polarization of the H$\alpha$ line and derive the intrinsic polarization component. The wavelength dependence of the intrinsic component is well explained by Thomson scattering in equatorial disk of the Be-type mass donor. The position angle (PA) of the intrinsic polarization $\sim 25^{\circ}$ represents the rotational axis of the Be disk. This PA is nearly perpendicular to the PA of the radio jet found during quiescent phases. Assuming an orthogonal disk-jet geometry around the compact star, the rotational axis of the accretion disk is almost perpendicular to that of the Be disk. Moreover, according to the orbital parameters of the microquasar, the compact star is likely to get across the Be disk around their periastron passage. We discuss the peculiar circumstellar structure of this microquasar inferred from our observation and possible connection with its high-energy activities.Comment: 17pages, 7figures; accepted for Publications of the Astronomical Society of Japa

Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts

<p>Abstract</p> <p>Background</p> <p>The authors examined whether milrinone and levosimendan could exert cardiac postconditioning effects in rats under normoglycemia and hyperglycemia, and whether the effects could be mediated by mitochondrial permeability transition pore (mPTP).</p> <p>Methods</p> <p>Wistar rats underwent 30-min coronary artery occlusion followed by 2-h reperfusion. The rats received milrinone or levosimendan just before reperfusion under normoglycemic or hyperglycemic conditions with or without atractyloside, an mPTP opener.</p> <p>Results</p> <p>Under normoglycemia, both 30 μg/kg milrinone (29 ± 12%) and 10 μg/kg levosimendan (33 ± 13%) reduced infarct size compared with that in the control (58 ± 7%). Under hyperglycemia, milrinone (34 ± 13%) reduced infarct size at the same dose as under normoglycemia. In contrast, neither 10 nor 30 μg/kg levosimendan protected hyperglycemic hearts, and only 100 μg/kg levosimendan (32 ± 9%) reduced infarct size compared with that in the hyperglycemic control (58 ± 13%). All of these cardioprotective effects under normoglycemia and hyperglycemia are abolished by atractyloside.</p> <p>Conclusion</p> <p>Milrinone and levosimendan exert postconditioning effects via inhibition of mPTP opening. Hyperglycemia raises the threshold of levosimendan-induced postconditioning, while milrinone-induced postconditioning is not influenced by hyperglycemia.</p

Uniqueness and examples of compact toric Sasaki-Einstein metrics

In [11] it was proved that, given a compact toric Sasaki manifold of positive basic first Chern class and trivial first Chern class of the contact bundle, one can find a deformed Sasaki structure on which a Sasaki-Einstein metric exists. In the present paper we first prove the uniqueness of such Einstein metrics on compact toric Sasaki manifolds modulo the action of the identity component of the automorphism group for the transverse holomorphic structure, and secondly remark that the result of [11] implies the existence of compatible Einstein metrics on all compact Sasaki manifolds obtained from the toric diagrams with any height, or equivalently on all compact toric Sasaki manifolds whose cones have flat canonical bundle. We further show that there exists an infinite family of inequivalent toric Sasaki-Einstein metrics on $S^5 \sharp k(S^2 \times S^3)$ for each positive integer $k$.Comment: Statements of the results are modifie

Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.

PURPOSE: It seems controversial whether or not neutrophil elastase inhibitors are effective in attenuating myocardial ischemia/reperfusion injury. We thus investigated possible protective effects of sivelestat, a neutrophil elastase inhibitor, against myocardial stunning i.e., prolonged myocardial dysfunction following a brief episode of ischemia. METHODS: Swine were divided into control group (group C), low-dose sivelestat group (group L), and high-dose sivelestat group (group H) (n = 7 for each group). All the swine were subjected to myocardial ischemia through ligation of the left anterior descending (LAD) coronary artery for 12-min, followed by 90-min reperfusion. Sivelestat was infused intracoronally at concentrations of 6 and 60 mg/ml throughout the reperfusion period in groups L and H, respectively, while saline was infused in the group C. Heart rate (HR), left ventricular developed pressure (LVdP), maximum rate of LVdP (LVdP/dt (max)), LV end-diastolic pressure (LVEDP), percentage of segment shortening (%SS, an index of regional myocardial contractility), and coronary venous interleukin-6 concentration in the LAD perfusion area were measured before ischemic induction and during reperfusion. RESULTS: The ischemia/reperfusion insult did not cause any significant changes in HR, LVdP, LVdP/dt (max), and LVEDP in all groups. However, it significantly reduced %SS in the LAD perfusion area and increased the interleukin-6 concentration in group C. Those changes in %SS and the interleukin-6 concentration were both greatly attenuated, but not prevented, in groups L and H. CONCLUSION: Sivelestat presumably attenuates myocardial contractile dysfunction due to myocardial stunning by inhibiting neutrophil-derived elastase, thereby suppressing the production of interleukin-6 in activated neutrophils

Direct effect of mild hypothermia on the coronary vasodilation induced by an ATP-sensitive K channel opener, a nitric oxide donor and isoflurane in isolated rat hearts.

PURPOSE: Deliberate mild hypothermia (MHT) is applied for cerebroprotection after cardiopulmonary resuscitation and during cardiac surgery. MHT has been shown to alter both contractility and relaxation of blood vessels in the brain. However, the effects of MHT on drug-induced vasodilation are not fully understood. The aim of this study was to clarify the effects of MHT on the coronary vasodilation induced by cromakalim (an ATP-sensitive K channel opener), S-nitroso acetyl-penicillamine (SNAP; a nitric oxide donor), and isoflurane in isolated rat hearts. METHODS: Male SD rat hearts were isolated and perfused with Krebs-Henseleit buffer. Coronary flow was measured with the coronary perfusion pressure kept at 60 mmHg, and coronary vascular resistance (CVR) was calculated. After cardiac arrest was induced by tetrodotoxin, the hearts were allocated to one of three temperature groups: 37, 34, and 31 degrees C (n = 7 for each). All groups received 0.01, 0.1, and 1.0 muM of either cromakalim or SNAP or were exposed to isoflurane at 1MAC and 2MAC. Finally, 50 mM of adenosine was administered to obtain maximal coronary vasodilation. RESULTS: CVR significantly increased after cardiac arrest, but did not change after the application of each temperature. Cromakalim, SNAP and isoflurane significantly decreased CVR in each temperature group. There were no significant differences in CVR among the three temperature groups with any of the test drugs. CONCLUSION: These results indicate that cromakalim-, SNAP-, and isoflurane-induced coronary vasodilation are not affected by MHT

High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: Role of mitochondrial KATP channels

Background: The current study was carried out to determine whether fasudil hydrochloride (fasudil), a Rho-kinase inhibitor, has myocardial postconditioning (PostC) activity under hyperglycemia as well as normoglycemia, and if so, whether the effects could be mediated by mitochondrial ATP-sensitive potassium (m-KATP) channels.Methods: Male Sprague-Dawley rats were anesthetized with sodium pentobarbital. After opening the chest, all rats underwent 30-min coronary artery occlusion followed by 2-h reperfusion. The rats received low-dose (0.15 mg/kg) or high-dose (0.5 mg/kg) fasudil or diazoxide, an m-KATP channel opener, at 10 mg/kg, just before reperfusion under normoglycemic or hyperglycemic conditions. In another group, rats received 5-hydroxydecanoic acid (5HD), an m-KATP channel blocker, at 10 mg/kg, before high-dose fasudil. Myocardial infarct size was expressed as a percentage of area at risk (AAR).Results: Under normoglycemia, low-dose and high-dose fasudil and diazoxide reduced myocardial infarct size (23 ± 8%, 21 ± 9% and 21 ± 10% of AAR, respectively) compared with that in the control (42 ± 7%). Under hyperglycemia, low-dose fasudil (40 ± 11%) and diazoxide (44 ± 14%) could not exert this beneficial effect, but high-dose fasudil reduced myocardial infarct size in the same manner as under normoglycemia (21 ± 13%). 5HD prevented fasudil-induced reduction of myocardial infarct size (42 ± 13%).Conclusion: Fasudil induces PostC against myocardial infarction via activation of m-KATP channels in the rat. Although hyperglycemia attenuates the PostC, high-dose fasudil can restore cardioprotection