TdIF1 recognizes a specific DNA sequence through its Helix-Turn-Helix and AT-hook motifs to regulate gene transcription

Peer reviewedPublisher PD

Relationship between the response to treatment and the prognosis of patients with aggressive lymphomas treated with chemotherapy followed by involved-field radiotherapy: Radiographic assessment

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in JAPANESE JOURNAL OF CLINICAL ONCOLOGY 38(1): 43-48, 2008 following peer review. The definitive publisher-authenticated version is available online at:http://jjco.oxfordjournals.org/cgi/content/full/38/1/43.ArticleJAPANESE JOURNAL OF CLINICAL ONCOLOGY. 38(1): 43-48 (2008)journal articl

A Study on Evaluations of the Behavior and Operational Skillsfor an Excavator Based on the Control Engineering Approach

広島大学(Hiroshima University)博士(工学)Doctor of Engineeringdoctora

Dosimetric Comparisons of Volumetric Modulated Arc Therapy with Three-Dimensional Conformal Radiation Therapy for Locally Advanced Non-Small Cell Lung Cancer

Article信州医学雑誌 65(2): 93-98(2017)journal articl

Degradation of Resorcinol by Pseudomonas putida R1

福山市内の土壌から集積培養法によってレゾルシンを唯一の炭素源として生育する細菌5株が分離された。その中でレゾルシンに最も良好に生育するNo.138株はPseudomonas putidaと同定された。 レゾルシン酸化活性の高い菌体は硝酸アンモニウムを窒素源とした時に得られた。本菌株のレゾルシン代謝系は誘導的であり,鉄イオン添加培地で生育した菌体は培地中のレゾルシンが消費されるとレゾルシン酸化活性は急激に減少した。しかし,鉄イオン無添加培地生育菌体はレゾルシン消費後でもその活性は保持されたが,その菌体は壊れやすかった。鉄イオン存在下でレゾルシン酸化活性の高い安定した菌体は,集菌30分前に0.05%程度のレゾルシンを再添加して集菌することにより得られた。本菌株の洗浄菌体のレゾルシン代謝系はレゾルシンと窒素源存在下で誘導された。Five bacterial strains capable of growing at the expense of resorcinol as a sole carbon source were isolated from soil by means of the enrichment culture method. Strain No. 138 with an ability to grow most abundantly on resorcinol was tentatively identified as Pseudomonas putida R1. Ammonium nitrate enhanced the production of cells with high resorcinol oxidizing activity. This activity did not decrease in the medium without addition of ferrous ion, even when the resorcinol was consumed completely. Enzymes to metabolise resorcinol in the strain were inducible. It was necessary to add 0.01－0.05% resorcinol before harvest in order to obtain a large amount of cells with high activity sufficient to oxidize the resorcinol. The resorcinol oxidizing system in the washed cells of the strain was induced in the presence of resorcinol and ammonium nitrate

Great Role in Gynecological Cancer Prophylaxis of a Unique Health Check-Up Institute, Ningen Dock in Japan (Review)

In Japan, there are unique facilities (namely Ningen Dock) for health check-up that provide asymptomatic participants with a health examination, including cancer screening activities, at their own expense. The most advanced examination equipment and examinations do not only provide high accuracy, but they also reduce stress on the body of the client. Usage of the medical equipment and diagnostic techniques allows us for successful detection of many diseases in their early stages of development. This early detection leads to quicker response for the disease. On the other hand, gynecological cancer screening is a relatively simple, low cost, and noninvasive method. In this chapter, we introduce a major role of Ningen Dock in gynecological malignancy prophylaxis. Ningen Dock attendances are associated with extremely low positive gynecology cancer screening incidence (0.03%). The level of knowledge and attitude toward screening may be related to multiple factors such as ethnicity, place of residence, income, and social-economic status. Not paying attention to cancer screening may be the risk factors for non-attendance to health check-up. These findings are of importance for improving the gynecological cancer screening practices of the lower screening attendance in Japan

Risk Factors for Severe Dysphagia after Concurrent Chemoradiotherapy for Head and Neck Cancers

The aim of this study was to investigate the risk factors for dysphagia induced by chemoradiotherapy for head and neck cancers. Forty-seven patients with head and neck cancers who underwent definitive chemoradiotherapy from December 1998 to March 2006 were reviewed retrospectively. Median age was 63 years (range, 16-81). The locations of the primary lesion were as follows: larynx in 18 patients, oropharynx in 11, nasopharynx in 7, hypopharynx in 7 and others in 4. Clinical stages were as follows: Stage II in 20 and Stages III-IV in 27. Almost all patients underwent platinum-based concomitant chemoradiotherapy. The median cumulative dose of cisplatin was 100 mg/m(2) (range, 80-300) and median radiation dose was 70 Gy (range, 50-70). Severe dysphagia (Grade 3-4) was observed in 22 patients (47%) as an acute toxic event. One patient required tube feeding even at 12-month follow-up. In univariate analysis, clinical stage (III-IV) (P = 0.017), primary site (oro-hypopharynx) (P = 0.041) and radiation portal size (> 11 cm) (P < 0.001) were found to be associated with severe dysphagia. In multivariate analysis, only radiation portal size was found to have a significant relationship with severe dysphagia (P = 0.048). Larger radiation portal field was associated with severe dysphagia induced by chemoradiotherapy.ArticleJAPANESE JOURNAL OF CLINICAL ONCOLOGY. 39(7):413-417 (2009)journal articl