Homovanillic acid in human cerebrospinal fluid.--Its concentration gradient and reduced levels in patients with epilepsy

The homovanillic acid (HVA) concentrations in the lumbar cerebrospinal fluid (CSF) were determined in 38 epileptic and 39 control patients. The mean concentration of HVA was 23.9 ng/ml +/- 2.8 SEM for the epileptic group and 30.2 ng/ml +/- 2.1 SEM for the control group, respectively. Thus, HVA was significandly reduced in the patients with epilepsy compared with the controls. The mean HVA in the female patients was higher than in the male patients in both groups but this failed to reach statistical significance. There was no apparent relationship between the degree of reduced HVA concentration and other clinical indexes of the epilepsy (age, type and frequency of seizures, and anticonvulsant medication). For the determination of concentration gradient of HVA three fractions of the spinal CSF were obtained from 11 patients. A pronounced gradient of HVA concentration was found with a ratio of 1 : 1.46 : 1.97 for the first, second and third fractions. This suggests that a standardized conditions for collecting CSF should be employed to study HVA levels in humans.</p

Somatic Findings of Melancholia with special reference to the endocrine system

1) 憂うつ病の身体的徴候を特に内分泌所見を中心として考察した. 2) 憂うつ状態では尿の17-KS分劃が減少し,血清の17-OHCS分劃の増加が見られる.憂うつ症にTestosterone系のものを与えると症状が改善したり,又ACTH注射やCortisol投与で悪化する事実から,憂うつ状態の成立には性腺系ホルモンの減少が関係していると考えられる. 3) 憂うつ病になる者には性腺系ホルモン代謝に潜在的な弱点があるのではなかろうかと思われる.1. Investigation was made on the patients with melancholia about their somatic conditions with special reference to the endocrine system. 2. As a result it has been found that in melancholia 17-KS fraction in urine is. decreased while serum 17-OHCS fraction is increased. Moreover, since the administration of androsterone or its series improves general conditions in melancholia and ACTH injection or cortisol medication aggravates the conditions, it is assumed that the decrease in sex hormones is responsible for the development of melancholia. 3. Those who are predisposed to melancholia seem to have latent weakness in the sex hormone metabolisms

Acta Medica Okayama Homovanillic acid in human cerebrospinal fluid.-Its concentration gradient and reduced levels in patients with epilepsy Homovanillic acid in human cerebrospinal fluid.-Its concentration gradient and reduced levels in patients with epil

Abstract The homovanillic acid (HVA) concentrations in the lumbar cerebrospinal fluid (CSF) were determined in 38 epileptic and 39 control patients. The mean concentration of HVA was 23.9 ng/ml +/-2.8 SEM for the epileptic group and 30.2 ng/ml +/-2.1 SEM for the control group, respectively. Thus, HVA was significandly reduced in the patients with epilepsy compared with the controls. The mean HVA in the female patients was higher than in the male patients in both groups but this failed to reach statistical significance. There was no apparent relationship between the degree of reduced HVA concentration and other clinical indexes of the epilepsy (age, type and frequency of seizures, and anticonvulsant medication). For the determination of concentration gradient of HVA three fractions of the spinal CSF were obtained from 11 patients. A pronounced gradient of HVA concentration was found with a ratio of 1 : 1.46 : 1.97 for the first, second and third fractions. This suggests that a standardized conditions for collecting CSF should be employed to study HVA levels in humans. Abstract. The homovanillic acid (HVA) concentrations in the lumbar cerebrospinal fluid (CSF) were determined in 38 epileptic and 39 control patients. The mean concentration of HVA was 23.9 ngjml ± 2.8 SEM for the epileptic group and 30.2 ngjml ± 2.1 SEM for the control group, respectively. Thus, HVA was significantly reduced in the patients with epilepsy compared with the controls. The mean HVA in the female patients was higher than in the male patients in both groups but this failed to reach statistical significance. There was no apparent relationship between the degree of reduced HVA concentration and other clinical indexes of the epilepsy (age, type and fTequency of seizures, and anticonvulsant medication). For the determination of concentration gradient of HVA three fractions of the spinal CSF were obtained from 11 patients. A pronounced gradient of HVA concentration was found with a ratio of 1: 1.46: 1.97 for the first, second and third fractions. This suggests that a standardized conditions for collecting CSF should be employed to study HVA levels in humans. KEYWORD

Lésions encéphaliques causées chez le Chat, par l\u27actinomycine D injectée dans le liquide céphalo-rachidien; comparaison avec l\u27acide actinomycinique

Société franco-japonaise de Biologie. Séance du 16 novembre 1973.Studies on histological changes induced in cat\u27s brain by actinomycin D and actinomycinic acid after intrarachidic injection 0,023 - 0,03 mg of these products. The chief effect of actinomycin D is a degeneration of neurons and of glial cells, in specifie regions of cortex, most severe in cochlear ventral and dorsal nuclei of Varole\u27s bridge. No specifie degenerative effect on cortical neurons after injection of actinomycinic acid

Lésions encéphaliques causées chez le Chat, par l'actinomycine D injectée dans le liquide céphalo-rachidien; comparaison avec l'acide actinomycinique

Studies on histological changes induced in cat's brain by actinomycin D and actinomycinic acid after intrarachidic injection 0,023 - 0,03 mg of these products. The chief effect of actinomycin D is a degeneration of neurons and of glial cells, in specifie regions of cortex, most severe in cochlear ventral and dorsal nuclei of Varole's bridge. No specifie degenerative effect on cortical neurons after injection of actinomycinic acid.Société franco-japonaise de Biologie. Séance du 16 novembre 1973

Corticoid Metabolism in the Body: Correlation Pattern of Blood and Urine Corticoids in Psychiatric Patients

To investigate the corticoid metabolism In Vivo of endogenous psychosis, authors have studied the relationship between urinary and serum corticoid patterns. Twenty four hour urine and blood samples were taken from 17 cases of both sexes of schizophrenic patients, 17 cases from both sexes of depressed patients, 17 cases from both sexes of normal control persons, 11 cases of right and left lobotomized chronic schizophsenic patients and 12 cases from both sexes of patients with pituitary tumors, pituitary cysts, craniopharyngeomas, disturbances in hypothalamus and so on. The urinary 17-KS were measured by a modified method of Koch and Holtorff and 17-OHCS were measured by Silber-Porter and Bongiovanni. Bacterial β Glucuronidase was used in hydrolysis. The results were as follows: 1. Free 17-OHCS in the urine and the serum were increased in schizophrenic and depressed patients in aggravating situations without exception. 2. Urinary 17-KS were decreased in aggravating situations in both schizophrenic and depressed patients. 3. The decrease of urinary 17-KS was significant in the male but not in the female. 4. High serum 17-CHCS levels were followed by high urine 17-OHCS values; in other words the values moved parallel in psychotic patients. 5. The value of conjugated 17-OHCS over free 17-OHCS (C/F) in the urine and blood always decreased in schizophrenic and depressed patients. 6. The ratios of urinary 17-KS over free serum 17-OHCS, and urinary total 17-OHCS over free serum 17-OHCS showed significant relationships in both schizophrenic and depressed patients; these ratios are decreased in an aghravating situation. 7. The frontal lobe plays a role in urinary 17-KS excretion. It should be emphasized that separating the frontal lobe from the thalamus or hypothalamus area will cause an increase in urinary 17-KS excretion. 8. Urinary or serum 17-OHCS values du not move in parallel to urinary 17-KS but rather in a reverse manner in psychotic patients