A unified approach to nonlinearity, structural change and outliers

This paper demonstrates that the class of conditionally linear and Gaussian state-space models offers a general and convenient framework for simultaneously handling nonlinearity, structural change and outliers in time series. Many popular nonlinear time series models, including threshold, smooth transition and Markov-Switching models, can be written in state-space form. It is then straightforward to add components that capture parameter instability and intervention effects. We advocate a Bayesian approach to estimation and inference, using an efficient implementation of Markov Chain Monte Carlo sampling schemes for such linear dynamic mixture models. The general modelling framework and the Bayesian methodology are illustrated by means of several examples. An application to quarterly industrial production growth rates for the G7 countries demonstrates the empirical usefulness of the approach

The Kohn mode for trapped Bose gases within the dielectric formalism

The presence of undamped harmonic center of mass oscillations of a weakly interacting Bose gas in a harmonic trap is demonstrated within the dielectric formalism for a previously introduced finite temperature approximation including exchange. The consistency of the approximation with the Kohn theorem is thereby demonstrated. The Kohn modes are found explicitly, generalizing an earlier zero-temperature result found in the literature. It is shown how the Kohn mode disappears from the single-particle spectrum, while remaining in the density oscillation spectrum, when the temperature increases from below to above the condensation temperature.Comment: 6 pages revte

SAGES Evidence-Based Guidelines for Surgical Treatment of Gastroesophageal Reflux Disease

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Decoherence of Bose-Einstein condensates in traps at finite temperature

The phase diffusion of the order parameter of trapped Bose-Einstein condensates at temperatures large compared to the mean trap frequency is determined, which gives the fundamental limit of the line-width of an atom laser. In addition a prediction of the correlation time of the number fluctuations in the condensate is made and related to the phase diffusion via the fluctuation-dissipation relation.Comment: 4 pages Revtex, revised version, to appear in Phys. Rev. Letter

Organics Verification Study for Sinclair and Dyes Inlets, Washington

Sinclair and Dyes Inlets near Bremerton, Washington, are on the State of Washington 1998 303(d) list of impaired waters because of fecal coliform contamination in marine water, metals in sediment and fish tissue, and organics in sediment and fish tissue. Because significant cleanup and source control activities have been conducted in the inlets since the data supporting the 1998 303(d) listings were collected, two verification studies were performed to address the 303(d) segments that were listed for metal and organic contaminants in marine sediment. The Metals Verification Study (MVS) was conducted in 2003; the final report, Metals Verification Study for Sinclair and Dyes Inlets, Washington, was published in March 2004 (Kohn et al. 2004). This report describes the Organics Verification Study that was conducted in 2005. The study approach was similar to the MVS in that many surface sediment samples were screened for the major classes of organic contaminants, and then the screening results and other available data were used to select a subset of samples for quantitative chemical analysis. Because the MVS was designed to obtain representative data on concentrations of contaminants in surface sediment throughout Sinclair Inlet, Dyes Inlet, Port Orchard Passage, and Rich Passage, aliquots of the 160 MVS sediment samples were used in the analysis for the Organics Verification Study. However, unlike metals screening methods, organics screening methods are not specific to individual organic compounds, and are not available for some target organics. Therefore, only the quantitative analytical results were used in the organics verification evaluation. The results of the Organics Verification Study showed that sediment quality outside of Sinclair Inlet is unlikely to be impaired because of organic contaminants. Similar to the results for metals, in Sinclair Inlet, the distribution of residual organic contaminants is generally limited to nearshore areas already within the actively managed Puget Sound Naval Shipyard and Intermediate Maintenance Facility Superfund Site, where further source-control actions and monitoring are under way

Collective excitations of degenerate Fermi gases in anisotropic parabolic traps

The hydrodynamic low-frequency oscillations of highly degenerate Fermi gases trapped in anisotropic harmonic potentials are investigated. Despite the lack of an obvious spatial symmetry the wave-equation turns out to be separable in elliptical coordinates, similar to a corresponding result established earlier for Bose-condensates. This result is used to give the analytical solution of the anisotropic wave equation for the hydrodynamic modes.Comment: 11 pages, Revte

Synthesis and Anticonvulsant Activities of ( R )- N -(4′-Substituted)benzyl 2-Acetamido-3-methoxypropionamides

The structure-activity relationship (SAR) for the N-benzyl group in the clinical antiepileptic agent (R)-lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-3) has been explored. Forty-three compounds were prepared and then evaluated at the National Institute of Neurological Disorders and Stroke Anticonvulsant Screening Program for seizure protection in the maximal electroshock (MES) and subcutaneous Metrazol models. Comparing activities for two series of substituted aryl regioisomers (2′, 3′, 4′) showed that 4′-modified derivatives had the highest activity. Significantly, structural latitude existed at the 4′-site. The SAR indicated that non-bulky 4′-substituted (R)-3 derivatives exhibited superb activity, independent of their electronic properties. Activities in the MES test of several compounds were either comparable with or exceeded that of (R)-3, and surpassed the activities observed for the traditional antiepileptic agents phenytoin, phenobarbital, and valproate