479 research outputs found
Effects of continuous positive airway pressure therapy on glucose metabolism in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis
Obstructive sleep apnoea is a highly prevalent chronic disorder and has been shown to be associated with disturbed glucose metabolism and type 2 diabetes. However, the evidence from individual clinical trials on the effect of continuous positive airway pressure (CPAP) treatment on glycaemic control in patients with co-existing obstructive sleep apnoea and type 2 diabetes remains controversial. A systematic review of randomised controlled trials assessing the effect of CPAP on glycaemic control in patients with obstructive sleep apnoea and type 2 diabetes was conducted using the databases MEDLINE, Embase, Cochrane and Scopus up to December 2022. Meta-analysis using a random-effect model was performed for outcomes that were reported in at least two randomised controlled trials. From 3031 records screened, 11 RCTs with a total of 964 patients were included for analysis. CPAP treatment led to a significant reduction in haemoglobin A1c (HbA1c) (mean difference −0.24%, 95% CI −0.43– −0.06%, p=0.001) compared to inactive control groups. Meta-regression showed a significant association between reduction in HbA1c and hours of nightly CPAP usage. CPAP therapy seems to significantly improve HbA1c and thus long-term glycaemic control in patients with type 2 diabetes and obstructive sleep apnoea. The amount of improvement is dependent on the hours of usage of CPAP and thus optimal adherence to CPAP should be a primary goal in these patients
High-Throughput Biochemical Fingerprinting of Saccharomyces cerevisiae by Fourier Transform Infrared Spectroscopy
Synthesizing Speech from Intracranial Depth Electrodes using an Encoder-Decoder Framework
Speech Neuroprostheses have the potential to enable communication for people
with dysarthria or anarthria. Recent advances have demonstrated high-quality
text decoding and speech synthesis from electrocorticographic grids placed on
the cortical surface. Here, we investigate a less invasive measurement modality
in three participants, namely stereotactic EEG (sEEG) that provides sparse
sampling from multiple brain regions, including subcortical regions. To
evaluate whether sEEG can also be used to synthesize high-quality audio from
neural recordings, we employ a recurrent encoder-decoder model based on modern
deep learning methods. We find that speech can indeed be reconstructed with
correlations up to 0.8 from these minimally invasive recordings, despite
limited amounts of training data
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