Concept study of a UV coronagraph spectrometer for the pinhole-occulter facility

The results of a very short study to define an Ultraviolet Coronagraph-Spectrometer (UVCS) for the Pinhole/Occulter Facility (P/OF) are summarized. The P/OF instrument was based on docummentation from the Definition Phase of the Spacelab Coronographs Program which was effectively completed in August 1980. The primary differences between the P/OF instrument and the Spacelab experiment are the remote occulter mask, the telescope size , and the deployable structure to accommodate P/OF's length restrictions. Requirement for P/OF that are associated with these features are briefly considered, but further study is need to more fully consider the unusual implications, particularly in the interplay between the instrument pointing and the P/OF boom control

Neurophysiological responses to stressful motion and anti-motion sickness drugs as mediated by the limbic system

Performance is characterized in terms of attention and memory, categorizing extrinsic mechanism mediated by ACTH, norepinephrine and dopamine, and intrinsic mechanisms as cholinergic. The cholinergic role in memory and performance was viewed from within the limbic system and related to volitional influences of frontal cortical afferents and behavioral responses of hypothalamic and reticular system efferents. The inhibitory influence of the hippocampus on the autonomic and hormonal responses mediated through the hypothalamus, pituitary, and brain stem are correlated with the actions of such anti-motion sickness drugs as scopolamine and amphetamine. These drugs appear to exert their effects on motion sickness symptomatology through diverse though synergistic neurochemical mechanisms involving the septohippocampal pathway and other limbic system structures. The particular impact of the limbic system on an animal's behavioral and hormonal responses to stress is influenced by ACTH, cortisol, scopolamine, and amphetamine

Computer assisted performance tests of the Lyman Alpha Coronagraph

Preflight calibration and performance tests of the Lyman Alpha Coronagraph rocket instrument in the laboratory, with the experiment in its flight configuration and illumination levels near those expected during flight were successfully carried out using a pulse code modulation telemetry system simulator interfaced in real time to a PDP 11/10 computer system. Post acquisition data reduction programs developed and implemented on the same computer system aided in the interpretation of test and calibration data

Lyman alpha coronagraph research sounding rocket program

The ultraviolet light coronagraph was developed and successfully flown on three rocket flights on 13 April 1979, 16 February 1980 and 20 July 1982. During each of these flights, the Ultraviolet Light Coronagraph was flown jointly with the White Light Coronagraph provided by the High Altitude Observatory. Ultraviolet diagnostic techniques and instrumentation for determining the basic plasma parameters of solar wind acceleration regions in the extended corona were developed and verified and the understanding of the physics of the corona through the performance, analysis and interpretation of solar observations advanced. Valuable UV diagnostics can be performed in the absence of a natural solar eclipse

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease. In order to efficiently establish a productive infection in mammalian cells, flaviviruses have developed key strategies to counteract host immune defences, including the type I interferon response. They employ different mechanisms to control interferon signal transduction and effector pathways, and key research generated over the past couple of decades has uncovered new insights into their abilities to actively decrease interferon antiviral activity. Given the lack of antivirals or prophylactic treatments for many flaviviral infections, it is important to fully understand how these viruses affect cellular processes to influence pathogenesis and disease outcome. This review will discuss the strategies mosquito-borne flaviviruses have evolved to antagonise type I interferon mediated immune responses

Unsuccessful In-Home Child Welfare Service Plans Following a Maltreatment Investigation: Racial and Ethnic Differences

Presents findings from the National Survey of Child and Adolescent Well-Being on racial/ethnic differences in recurrent maltreatment and the probability of a recurrent report or placement into out-of-home care within thirty-six months of an investigation

Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses

The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae)

Reactions of NaCl with Gaseous SO3, SO2, and O2

Hot corrosion of gas turbine engine components involves deposits of Na2SO4 which are produced by reactions between NaCl and oxides of sulfur. For the present investigation, NaCl single crystals were exposed at 100 to 850 C to gaseous mixtures of SO3, SO2, and O2. The products formed during this exposure depend, primarily, on the temperatures. The four product films were: NaCl-SO3; Na2S2O7; Na2SO4; and NaCl-Na2SO4. The kinetics of the reactions were measured