Review of Tranquebar―Whose History? Transnational Cultural Heritage in a Former Danish Trading Colony in South India, by Helle Jørgensen, New Delhi, Orient BlackSwan, 2014, xi + 356pp., $40/£42, Hardcover, ISBN 9788125053453

Jørgensen examines the emergence of Tranquebar as a heritage town in post-colonial India through the diverse, sometimes competing interests and claims of local residents, state-oriented institutions, scholars and policy makers, non-governmental organisations, and private entrepreneurs. Tharangambadi, Nagapattinam, Tamil Nadu, colloquially known as Tranquebar, is a fishing community of about 23000 people on the Coromandel Coast of India. Tranquebar was one of two trading posts that the Danish East India Company established in the 1600s, and that were taken over by the Danish Crown in 1650. The British East India Company acquired Denmark‟s Indian territories in 1845, and they were subsequently taken over in 1857 by the British Crown when the Company was dissolved. These territories were transferred to the Indian national government in 1947, when India gained independence from the British Crown. Jørgensen investigates the use of the past, that is, the making of Tranquebar into a destination for heritage tourism based on its Danish colonial history. The study takes place in the aftermath of the Indian Ocean earthquake on December 26, 2004. This major seismic event centred in the west coast of Sumatra, resulted in a powerful tsunami that radiated from there toward each country that shares a coastline on the Indian Ocean. The tsunami inundation in turn, caused the destruction of infrastructure, towns and villages, the displacement of coastal communities and the loss of human life. Tranquebar was severely impacted and since the tsunami, initiatives to promote economic growth in the town have intensified

Auditory and Visual Durations Load a Unitary Working-Memory Resource

Items in working memory are typically defined by various attributes, such as colour (for visual objects) and pitch (for auditory objects). The attribute of duration can be signalled by multiple modalities, but has received relatively little attention from a working-memory perspective. While the existence of specialist stores (e.g., the phonological loop and visuospatial sketchpad) is often asserted in the wider working-memory literature, the interval-timing literature has more often implied a unitary (amodal) store. Here we combine two modelling frameworks to probe the basis of working memory for duration; a Bayesian-observer framework, previously used to explain behaviour in duration-reproduction tasks, and mixture models, describing distributions of continuous reports about items in working memory. We modelled different storage mechanisms, such as a limited number of fixed-resolution slots or a resource spread between items at a cost to resolution, in order to ask whether items from different sensory modalities are maintained in separate, independent stores. We initially analysed data from 32 participants, who memorised between one and eight items before reproducing the duration of a randomly selected target. In separate blocks, items could be all visual, all auditory, or an alternating mixture of both. A small control experiment included a further condition with precuing of target modality. Certain kinds of slot models, resource models, and combination models incorporating both mechanisms could account for the data. However, looking across all plausible models, the decline in performance with increasing memory load was most consistent with a single store for event durations, regardless of stimulus modality

Reevaluation of experiments and new theoretical calculations for electron-impact excitation of C3+

Experimental absolute-rate coefficients for electron-impact excitation of C3+ (2s2S1/2→2p2P1/2,3/2) near threshold [D. W. Savin, L. D. Gardner, D. B. Reisenfeld, A. R. Young, and J. L. Kohl, Phys. Rev. A 51, 2162 (1995)] have been reanalyzed to include a more accurate determination of optical efficiency and revised radiometric uncertainties which reduce the total systematic uncertainty of the results. Also, new R matrix with pseudostates (RMPS) calculations for this transition near threshold are presented. Comparison of the RMPS results to those of simpler close-coupling calculations indicates the importance of accounting for target continuum effects. The reanalyzed results of Savin et al. are in excellent agreement with the RMPS calculations; comparisons are also made to other measurements of this excitation. Agreement with the RMPS results is better for fluorescence technique measurements than for electron-energy-loss measurements

The Neurodynamic Decision Variable in Human Multi-Alternative Perceptual Choice

The neural dynamics underpinning binary perceptual decisions and their transformation into actions are well studied, but real-world decisions typically offer more than two response alternatives. How does decision-related evidence accumulation dynamically influence multiple action representations in humans? The heightened conservatism required in multiple compared to binary choice scenarios suggests a mechanism which compensates for increased uncertainty when multiple choices are present by supressing baseline activity. Here, we tracked action representations using corticospinal excitability during four and two-choice perceptual decisions, and modelled them using a sequential sampling framework. We found that the predictions made by leaky competing accumulator models in order to accommodate multiple choices (i.e. reduced baseline activity to compensate increased uncertainty) were borne out by dynamic changes in human action representations. This suggests a direct and continuous influence of interacting evidence accumulators, each favouring a different decision alternative, on downstream corticospinal excitability during complex choice

RecycleNet: Latent Feature Recycling Leads to Iterative Decision Refinement

Despite the remarkable success of deep learning systems over the last decade, a key difference still remains between neural network and human decision-making: As humans, we cannot only form a decision on the spot, but also ponder, revisiting an initial guess from different angles, distilling relevant information, arriving at a better decision. Here, we propose RecycleNet, a latent feature recycling method, instilling the pondering capability for neural networks to refine initial decisions over a number of recycling steps, where outputs are fed back into earlier network layers in an iterative fashion. This approach makes minimal assumptions about the neural network architecture and thus can be implemented in a wide variety of contexts. Using medical image segmentation as the evaluation environment, we show that latent feature recycling enables the network to iteratively refine initial predictions even beyond the iterations seen during training, converging towards an improved decision. We evaluate this across a variety of segmentation benchmarks and show consistent improvements even compared with top-performing segmentation methods. This allows trading increased computation time for improved performance, which can be beneficial, especially for safety-critical applications.Comment: Accepted at 2024 Winter Conference on Applications of Computer Vision (WACV

Drosophila FANCM Helicase Prevents Spontaneous Mitotic Crossovers Generated by the MUS81 and SLX1 Nucleases

Several helicases function during repair of double-strand breaks and handling of blocked or stalled replication forks to promote pathways that prevent formation of crossovers. Among these are the Bloom syndrome helicase BLM and the Fanconi anemia group M (FANCM) helicase. To better understand functions of these helicases, we compared phenotypes of Drosophila melanogaster Blm and Fancm mutants. As previously reported for BLM, FANCM has roles in responding to several types of DNA damage in preventing mitotic and meiotic crossovers and in promoting the synthesis-dependent strand annealing pathway for repair of a double-strand gap. In most assays, the phenotype of Fancm mutants is less severe than that of Blm mutants, and the phenotype of Blm Fancm double mutants is more severe than either single mutant, indicating both overlapping and unique functions. It is thought that mitotic crossovers arise when structure-selective nucleases cleave DNA intermediates that would normally be unwound or disassembled by these helicases. When BLM is absent, three nucleases believed to function as Holliday junction resolvases—MUS81-MMS4, MUS312-SLX1, and GEN—become essential. In contrast, no single resolvase is essential in mutants lacking FANCM, although simultaneous loss of GEN and either of the others is lethal in Fancm mutants. Since Fancm mutants can tolerate loss of a single resolvase, we were able to show that spontaneous mitotic crossovers that occur when FANCM is missing are dependent on MUS312 and either MUS81 or SLX1

Separated cross sections in \pi^0 electroproduction at threshold at Q^2 = 0.05 GeV^2/c^2

The differential cross sections \sigma_0=\sigma_T+\epsilon \sigma_L, \sigma_{LT}, and \sigma_{TT} of \pi^0 electroproduction from the proton were measured from threshold up to an additional center of mass energy of 40 MeV, at a value of the photon four-momentum transfer of Q^2= 0.05 GeV^2/c^2 and a center of mass angle of \theta=90^\circ. By an additional out-of-plane measurement with polarized electrons \sigma_{LT'} was determined. This showed for the first time the cusp effect above the \pi^+ threshold in the imaginary part of the s-wave. The predictions of Heavy Baryon Chiral Perturbation Theory are in disagreement with these data. On the other hand, the data are somewhat better predicted by the MAID phenomenological model and are in good agreement with the dynamical model DMT.Comment: 6 pages, 4 figure

Spin-Dependent Electron Scattering from Polarized Protons and Deuterons with the BLAST Experiment at MIT-Bates

The Bates Large Acceptance Spectrometer Toroid (BLAST) experiment was operated at the MIT-Bates Linear Accelerator Center from 2003 until 2005. The experiment was designed to exploit the power of a polarized electron beam incident on polarized targets of hydrogen and deuterium to measure, in a systematic manner, the neutron, proton, and deuteron form factors as well as other aspects of the electromagnetic interaction on few-nucleon systems. We briefly describe the experiment, and present and discuss the numerous results obtained.United States. Dept. of EnergyNational Science Foundation (U.S.

Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific proteolytic target and essential structural protein inside Ca2+ release units required for excitation-contraction coupling in cardiomyocytes. While downregulation of JP2 by Calpain cleavage in heart failure has been reported, the precise molecular identity of the Calpain cleavage sites and the (patho-)physiological roles of the JP2 proteolytic products remain controversial. We systematically analyzed the JP2 cleavage fragments as function of Calpain-1 versus Calpain-2 proteolytic activities, revealing that both Calpain isoforms preferentially cleave mouse JP2 at R565, but subsequently at three additional secondary Calpain cleavage sites. Moreover, we identified the Calpain-specific primary cleavage products for the first time in human iPSC-derived cardiomyocytes. Knockout of RyR2 in hiPSC-cardiomyocytes destabilized JP2 resulting in an increase of the Calpain-specific cleavage fragments. The primary N-terminal cleavage product NT1 accumulated in the nucleus of mouse and human cardiomyocytes in a Ca2+-dependent manner, closely associated with euchromatic chromosomal regions, where NT1 is proposed to function as a cardio-protective transcriptional regulator in heart failure. Taken together, our data suggest that stabilizing NT1 by preventing secondary cleavage events by Calpain and other proteases could be an important therapeutic target for future studies