Induzieren zytotoxische Behandlungen von Mammakarzinomzellen eine Tumorzell-Dedifferenzierung in-vitro?

Tumorzellen können im Laufe der Behandlung Resistenzen gegenüber zytotoxischen Behandlungen entwickeln. In dieser Arbeit wurde untersucht, ob durch die zytotoxische Behandlung von Mammakarzinomzellen in vitro Resistenzen entstanden sind und ob diese durch die Entstehung eines mesenchymalen Phänotyps der Zellen erlangt wurde. Es wurden dabei verschiedene Oberflächenmoleküle, Proteine und funktionelle Eigenschaften untersucht, die in Verbindung mit Epithelial-mesenchymaler Transition (EMT) bzw. Krebsstammzellen (CSC) stehen

She Would Not Be Moved: How We Tell the Story of Rosa Parks and the Montgomery Bus Boycott

Evaluates the ways in which the story of Rosa Parks and the Montgomery bus boycott is misrepresented to children.https://scholar.dominican.edu/books/1021/thumbnail.jp

Towards a Unified IU Environment: Coordination of Existing IU Tools with the IUE

Progress in the field of Computer Vision/Image Understanding has long been hampered by the lack of standard software environments for research and application development. The Image Understanding Environment (IUE) is being implemented to provide a freely distributed standard software environment appropriate for a wide range of research and development activities. Nevertheless, we recognize that the IUE will not serve everyone's individual needs and that conversion to the IUE could be an expensive process for many sites. Therefore, we are investing significant effort to make the IUE an open environment that can work in coordination with existing IU systems and tools. This paper introduces the work being performed at Amerinex A.I. to address the processing and data representation factors involved in this coordination. 1 Requirements of a unified image understanding environment A long-standing problem in Image Understanding research has been the lack of established software standards or..

Assessment of breast cancer primary tumor material in a 3D in vivo model

BACKGROUND: Breast cancer is the most common malignant tumor in women and highly heterogeneous with a variety of different molecular subtypes. The analysis of the individual tumor biology is necessary to develop a specific and individualized treatment plan for every patient. The chick chorioallantoic membrane (CAM) model, a 3D-in-vivo-tumor-model, could potentially provide a methodology that facilitates the gain of additional information regarding the tumor biology as well as the testing of the tumor's individual sensitivity to different therapies. OBJECTIVE: The objective was to establish the grafting of different breast cancer primaries onto the CAM for tumor profiling and the investigation of different parameters. METHODS: Breast cancer primary tissue of different patients was grafted onto the CAM. Subsequently, 3D volume and perfusion measurements were performed during the engraftment period. Histological analyses of the tumors were carried out after the engraftment period. RESULTS: The grafting of the breast cancer primaries onto the CAM was successful. The tumors remained partially vital and displayed angiogenic development on the CAM. CONCLUSIONS: Breast cancer primary material can be grafted onto the CAM and we observed visible and measurable changes of perfusion over time

Treatment of endometrial cancer from 2000 to 2020 in Germany: a retrospective population based cohort study

Purpose Endometrial cancer (EC) is one of the most common malignancies among women in western countries. This study aimed to assess data on patient treatment in Germany throughout two decades to evaluate the development and effect of surgery, radiation, and chemotherapy. Methods This retrospective registry study included 34,349 EC patients diagnosed between 2000 and 2020. Patients were classified into five risk groups. Overall survival was analyzed by Kaplan–Meier method as well as univariable and multivariable Cox regression to evaluate risk factors and treatment options. Results Over the study period, minimal invasive surgery was used more often compared to open surgery and was associated with better overall survival. Patients with advanced EC were more likely to receive multimodal therapy. Patients with intermediate risk EC had a good prognosis upon surgery, which further improved when radiotherapy was added. High-risk patients showed poorer prognosis but clearly benefited from additional radiotherapy. Survival of elderly high-risk patients with a non-endometrioid histology was improved when chemotherapy was added to surgery and radiotherapy. Conclusion Our study includes a large analysis of data from German clinical cancer registries on the care of endometrial cancer during two decades. We observed an increase of minimal invasive surgery. There is evidence that minimal invasive surgery is not inferior to open surgery. Adjuvant radio- and chemotherapy further improves survival depending on risk group and age

International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass.

Mycobacterial infection-related morbidity and mortality in patients following cardiopulmonary bypass surgery is high and and there is a growing need for a consensus-based expert opinion to provide international guidance for diagnosing, preventing and treating in these patients. In this document the International Society for Cardiovascular Infectious Diseases (ISCVID) covers aspects of prevention (field of hospital epidemiology), clinical management (infectious disease specialists, cardiac surgeons, ophthalmologists, others), laboratory diagnostics (microbiologists, molecular diagnostics), device management (perfusionists, cardiac surgeons) and public health aspects