716 research outputs found
Local Tunneling Study of Three-Dimensional Order Parameter in the -band of Al-doped MgB Single Crystals
We have performed local tunneling spectroscopy on high quality
MgAlB single crystals by means of Variable Temperature Scanning
Tunneling Spectroscopy (STS) in magnetic field up to 3 Tesla. Single gap
conductance spectra due to c-axis tunneling were extensively measured, probing
different amplitudes of the three-dimensional as a function of Al
content. Temperature and magnetic field dependences of the conductance spectra
were studied in S-I-N configuration: the effect of the doping resulted in a
monotonous reduction of the locally measured down to 24K for x=0.2. On
the other hand, we have found that the gap amplitude shows a maximum value
meV for x=0.1, while the ratio increases
monotonously with doping. The locally measured upper critical field was found
to be strongly related to the gap amplitude, showing the maximum value
for x=0.1 substituted samples. For this Al concentration the
data revealed some spatial inhomogeneity in the distribution of on
nanometer scale.Comment: 4 pages, 3 figure
Probing the superconducting condensate on a nanometer scale
Superconductivity is a rare example of a quantum system in which the
wavefunction has a macroscopic quantum effect, due to the unique condensate of
electron pairs. The amplitude of the wavefunction is directly related to the
pair density, but both amplitude and phase enter the Josephson current : the
coherent tunneling of pairs between superconductors. Very sensitive devices
exploit the superconducting state, however properties of the {\it condensate}
on the {\it local scale} are largely unknown, for instance, in unconventional
high-T cuprate, multiple gap, and gapless superconductors.
The technique of choice would be Josephson STS, based on Scanning Tunneling
Spectroscopy (STS), where the condensate is {\it directly} probed by measuring
the local Josephson current (JC) between a superconducting tip and sample.
However, Josephson STS is an experimental challenge since it requires stable
superconducting tips, and tunneling conditions close to atomic contact. We
demonstrate how these difficulties can be overcome and present the first
spatial mapping of the JC on the nanometer scale. The case of an MgB film,
subject to a normal magnetic field, is considered.Comment: 7 pages, 6 figure
Andreev reflections on Y1-xCaxBa2Cu3O7-delta evidence for an unusual proximity effect
We have measured Andreev reflections between an Au tip and
Y_{1-x}Ca_{x}Ba_{2}Cu_{3}O_{7 - \delta} thin films in the in-plane orientation.
The conductance spectra are best fitted with a pair potential having the
"d_{x^{2}-y^{2}+is" symmetry. We find that the amplitude of the "is" component
is enhanced as the contact transparency is increased. This is an indication for
an unusual proximity effect that modifies the pair potential in the
superconductor near the surface with the normal metal.Comment: 4 pages, 4 figure
Reply to Comment on "Completely positive quantum dissipation"
This is the reply to a Comment by R. F. O'Connell (Phys. Rev. Lett. 87 (2001)
028901) on a paper written by the author (B. Vacchini, ``Completely positive
quantum dissipation'', Phys.Rev.Lett. 84 (2000) 1374, arXiv:quant-ph/0002094).Comment: 2 pages, revtex, no figure
Symmetry and Temperature dependence of the Order parameter in MgB2 from point contact measurements
We have performed differential conductance versus voltage measurements of
Au/MgB2 point contacts. We find that the dominant component in the conductance
is due to Andreev reflection. The results are fitted to the theoretical model
of BTK for an s-wave symmetry from which we extract the value of the order
parameter (Delta) and its temperature dependence. From our results we also
obtain a lower experimental bound on the Fermi velocity in MgB2.Comment: 7 pages (Including figure captions) and 4 figure
Quantum Transition State Theory for proton transfer reactions in enzymes
We consider the role of quantum effects in the transfer of hyrogen-like
species in enzyme-catalysed reactions. This study is stimulated by claims that
the observed magnitude and temperature dependence of kinetic isotope effects
imply that quantum tunneling below the energy barrier associated with the
transition state significantly enhances the reaction rate in many enzymes. We
use a path integral approach which provides a general framework to understand
tunneling in a quantum system which interacts with an environment at non-zero
temperature. Here the quantum system is the active site of the enzyme and the
environment is the surrounding protein and water. Tunneling well below the
barrier only occurs for temperatures less than a temperature which is
determined by the curvature of potential energy surface near the top of the
barrier. We argue that for most enzymes this temperature is less than room
temperature. For physically reasonable parameters quantum transition state
theory gives a quantitative description of the temperature dependence and
magnitude of kinetic isotope effects for two classes of enzymes which have been
claimed to exhibit signatures of quantum tunneling. The only quantum effects
are those associated with the transition state, both reflection at the barrier
top and tunneling just below the barrier. We establish that the friction due to
the environment is weak and only slightly modifies the reaction rate.
Furthermore, at room temperature and for typical energy barriers environmental
degrees of freedom with frequencies much less than 1000 cm do not have a
significant effect on quantum corrections to the reaction rate.Comment: Aspects of the article are discussed at
condensedconcepts.blogspot.co
Estrogen Metabolites in Human Corpus Luteum Physiology: Differential Effects on Angiogenic Activity
OBJECTIVE: To determine tissue concentrations of E2, estrone, P, and estrogens metabolites (EMs) 2-methoxyestradiol, 2-methoxyestrone, 4-hydroxyestrone, and 16-ketoestradiol in corpus luteum (CL) of different ages, and after hCG administration; and to examine the effects of EMs on vascular endothelial growth factor (VEGF) secretion and angiogenic activity released by cultured luteinizing granulosa cells in the presence and absence of hCG.
DESIGN: Experimental study.
SETTING: University.
PATIENT(S): Thirty-two healthy women of reproductive age.
INTERVENTION(S): Corpus luteum was collected at the time of minilaparotomy for tubal sterilization, at varying stages of the luteal phase (LP). Late-LP CL was collected 24 hours after IM administration of 10,000 IU hCG. Granulosa cells were isolated from follicular aspirates obtained from healthy women participating in our IVF program for male factor infertility.
MAIN OUTCOMES MEASURE(S): Estrogen metabolite concentrations were determined in CL tissue, and VEGF was assessed in conditioned medium. The angiogenic activity was analyzed by bioassay.
RESULT(S): Concentrations of EMs with proangiogenic activity (16-ketoestradiol and 4-hydroxyestrone) were higher in early and mid-LP CL vs. late-LP CL. These EMs and hCG increased VEGF production and angiogenic activity. Conversely, late-LP CL had significantly higher levels of 2-methoxyestrone and 2-methoxyestradiol, which have antiangiogenic activity. Administration of hCG reduced the production of these EMs.
CONCLUSION(S): Our findings suggest that the EMs are important paracrine modulators of CL function. Administration of hCG increases the production of EMs with proangiogenic activity and reduces the secretion of those EMs with antiangiogenic action, suggesting a novel mechanism by which the late-LP CL is rescued in conception cycles
Conceptualizing childhood health problems using survey data: a comparison of key indicators
<p>Abstract</p> <p>Background</p> <p>Many definitions are being used to conceptualize child health problems. With survey data, commonly used indicators for identifying children with health problems have included chronic condition checklists, measures of activity limitations, elevated service use, and health utility thresholds. This study compares these different indicators in terms of the prevalence rates elicited, and in terms of how the subgroups identified differ.</p> <p>Methods</p> <p>Secondary data analyses used data from the National Longitudinal Survey of Children and Youth, which surveyed a nationally representative sample of Canadian children (n = 13,790). Descriptive analyses compared healthy children to those with health problems, as classified by any of the key indicators. Additional analyses examined differences between subgroups of children captured by a single indicator and those described as having health problems by multiple indicators.</p> <p>Results</p> <p>This study demonstrates that children captured by any of the indicators had poorer health than healthy children, despite the fact that over half the sample (52.2%) was characterized as having a health problem by at least one indicator. Rates of child ill health differed by indicator; 5.6% had an activity limitation, 9.2% exhibited a severe health difficulty, 31.7% reported a chronic condition, and 36.6% had elevated service use. Further, the four key indicators captured different types of children. Indicator groupings differed on child and socio-demographic factors. Compared to children identified by more than one indicator, those identified only by the severe health difficulty indicator displayed more cognitive problems (p < 0.0001), those identified only by the chronic condition checklist had a greater likelihood of reporting allergies or asthma (p < 0.0001), and those identified as having elevated service use only were more affluent (p = 0.01) and showed better overall health (p < 0.0001). Children identified by only a single indicator were less likely to have serious health problems than those identified by two or more indicators.</p> <p>Conclusion</p> <p>We provide information useful to researchers when selecting indicators from survey data to identify children with health problems. Researchers and policy makers need to be aware of the impact of such definitions on prevalence rates as well as on the composition of children classified as being in poor health.</p
Estrogen-Receptor Expression and Function in Thymocytes in Relation to Gender and Age
The expression of estrogen receptor (ER) in thymocytes was studied in young, middle-aged, and
old (2, 12, and 24 months, respectively) female and male C57BL/6J mice. Western immunoblots
prepared from the thymocytes of females of all age groups showed the presence of a 67-kD
protein band, which has been associated with the apparent MW of denatured ER. Flow cytometry
analysis o,f cells stained with a monoclonal anti-ER antibody (clone 13H2) disclosed ER
expression in both females and males of all age groups. In vivo treatment with estradiol (E2) led
to an increase in the specific activity of thymic creatine kinase (CK) in the female mice, whereas
the male thymocytes responded with an increase in CK activity only on treatment with
dihydrotestosterone (DHT). The data show no differences in ER expression between male and
females, but the receptor appears not to be functional in males. Interestingly, when estradiol was
applied to co-cultures of lymphoid-depleted fetal thymus (FT) explants and bone-marrow cells,
or thymocytes, from young and old females, it resulted in increased cellularity of cultures
containing cells of the young, and not those of the old. The proportion of CD4/CD8 phenotypes
of the developing cells in these cultures was not affected by E2 treatment. These observations
provide a new insight into ER expression and function in T-cell development in relation to
gender and age
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