Development of α - β type titanium alloy Ti-4.5Al-2.5Cr-1.2Fe-0.1C-0.3Cu-0.3Ni having good forgeability and machinability

Development of a titanium alloy having excellent hot forgeability and machinability while having the same properties as Ti-64 alloy is effective in reducing the total cost of titanium parts. To develop a new alpha-beta type titanium alloy which has good hot forgeability, machinability and tensile properties equivalent to those of Ti-64 alloy at room temperature, Ti-4.5Al-2.5Cr-1.2Fe-0.1C-nCu-nNi (n=0 to 2) were prepared and evaluated. The new alloy showed tensile properties equivalent to that of Ti-64 alloy at room temperature. On the other hand, the hot deformation stress of new alloy was about 30% lower than that of Ti-64 alloy, and the excellent deformability was confirmed. The addition of Cu and Ni to Ti-4.5Al-2.5Cr-1.2Fe-0.1C alloy suppressed the amount of wear of tool and improved the machinability. Tool life of new alloy machining is extended by about 1.5 times compared to that of Ti-64 alloy. Addition of Cu and Ni is considered to reduce the reactivity between tool and workpiece and improve machinability

Development of α - β type titanium alloy Ti-4.5Al-2.5Cr-1.2Fe-0.1C-0.3Cu-0.3Ni having good forgeability and machinability

Development of a titanium alloy having excellent hot forgeability and machinability while having the same properties as Ti-64 alloy is effective in reducing the total cost of titanium parts. To develop a new alpha-beta type titanium alloy which has good hot forgeability, machinability and tensile properties equivalent to those of Ti-64 alloy at room temperature, Ti-4.5Al-2.5Cr-1.2Fe-0.1C-nCu-nNi (n=0 to 2) were prepared and evaluated. The new alloy showed tensile properties equivalent to that of Ti-64 alloy at room temperature. On the other hand, the hot deformation stress of new alloy was about 30% lower than that of Ti-64 alloy, and the excellent deformability was confirmed. The addition of Cu and Ni to Ti-4.5Al-2.5Cr-1.2Fe-0.1C alloy suppressed the amount of wear of tool and improved the machinability. Tool life of new alloy machining is extended by about 1.5 times compared to that of Ti-64 alloy. Addition of Cu and Ni is considered to reduce the reactivity between tool and workpiece and improve machinability

コウレイシャ オヨビ チュウコウネンソウ ニ オケル ウンドウ シュウカン ト ジョウホウ シュウカン ト ノ カンレン

　中高年以上の人々における過去と現在の運動習慣および情報との関わりについて，調査紙を配付することによって調べた。50歳以上の142名を分析の対象とした。得られた回答を運動習慣の有無および中高年群（50～69歳）と高齢群（70歳以上）に分けて4グループとした。結果として，運動習慣の無い中高年群は，「運動したい」と思っているが「何をやって良いか分からない」という回答が複数あった。このような人々へは情報を届ける方策が必要となる。情報習慣では，運動習慣の有る中高年群において，図書館を利用する人が多かった。高齢群は全般的に受動型のメディアから情報を受け取ることが多く，中高年群は能動型メディアから受け取ることが多かった。さらに，運動習慣の無い中高年群においては，趣味に関する情報と健康に関する情報に応じて使用するメディアが異なる傾向を示した

Expanding the phenotype of IBA57 mutations: related leukodystrophy can remain asymptomatic

Biallelic mutations in IBA57 cause a mitochondrial disorder with a broad phenotypic spectrum that ranges from severe intellectual disability to adolescent-onset spastic paraplegia. Only 21 IBA57 mutations have been reported, therefore the phenotypic spectrum of IBA57-related mitochondrial disease has not yet been fully elucidated. In this study, we performed whole-exome sequencing on a Sepharadi Jewish and Japanese family with leukodystrophy. We identified four novel biallelic variants in IBA57 in the two families: one frameshift insertion and three missense variants. The three missense variants were predicted to be disease-causing by multiple in silico tools. The 29-year-old Sepharadi Jewish male had infantile-onset optic atrophy with clinically asymptomatic leukodystrophy involving periventricular white matter. The 19-year-old younger brother, with the same compound heterozygous IBA57 variants, had a similar clinical course until 7 years of age. However, he then developed a rapidly progressive spastic paraparesis following a febrile illness. A 7-year-old Japanese girl had developmental regression, spastic quadriplegia, and abnormal periventricular white matter signal on brain magnetic resonance imaging performed at 8 months of age. She had febrile convulsions at the age of 18 months and later developed epilepsy. In summary, we have identified four novel IBA57 mutations in two unrelated families. Consequently, we describe a patient with infantile-onset optic atrophy and asymptomatic white matter involvement, thus broadening the phenotypic spectrum of biallelic IBA57 mutations

First asteroid gas sample delivered by the Hayabusa2 mission:A treasure box from Ryugu

「はやぶさ2」ミッションによる世界初の小惑星からのガスサンプル：リュウグウからのたまて箱. 京都大学プレスリリース. 2022-10-21.The Hayabusa2 spacecraft returned to Earth from the asteroid 162173 Ryugu on 6 December 2020. One day after the recovery, the gas species retained in the sample container were extracted and measured on-site and stored in gas collection bottles. The container gas consists of helium and neon with an extraterrestrial ³He/⁴He and ²⁰Ne/²²Ne ratios, along with some contaminant terrestrial atmospheric gases. A mixture of solar and Earth’s atmospheric gas is the best explanation for the container gas composition. Fragmentation of Ryugu grains within the sample container is discussed on the basis of the estimated amount of indigenous He and the size distribution of the recovered Ryugu grains. This is the first successful return of gas species from a near-Earth asteroid

Noble gases and nitrogen in samples of asteroid Ryugu record its volatile sources and recent surface evolution

International audienceThe near-Earth carbonaceous asteroid (162173) Ryugu is expected to contain volatile chemical species that could provide information on the origin of Earth’s volatiles. Samples of Ryugu were retrieved by the Hayabusa2 spacecraft. We measure noble gas and nitrogen isotopes in Ryugu samples, finding they are dominated by pre-solar and primordial components, incorporated during Solar System formation. Noble gas concentrations are higher than those in Ivuna-type carbonaceous (CI) chondrite meteorites. Several host phases of isotopically distinct nitrogen have heterogeneous abundances between the samples. Our measurements support a close relationship between Ryugu and CI chondrites. Noble gases produced by galactic cosmic rays, indicating ~5 Myr exposure, and from implanted solar wind, record the recent irradiation history of Ryugu after it migrated to its current orbit