Interrelationship between Lab, Space, Astrophysical, Magnetic Fusion, and Inertial Fusion Plasma Experiments

The objectives of this review are to articulate geospace, heliospheric, and astrophysical plasma physics issues that are addressable by laboratory experiments, to convey the wide range of laboratory experiments involved in this interdisciplinary alliance, and to illustrate how lab experiments on the centimeter or meter scale can develop, through the intermediary of a computer simulation, physically credible scaling of physical processes taking place in a distant part of the universe over enormous length scales. The space physics motivation of laboratory investigations and the scaling of laboratory plasma parameters to space plasma conditions, having expanded to magnetic fusion and inertial fusion experiments, are discussed. Examples demonstrating how laboratory experiments develop physical insight, validate or invalidate theoretical models, discover unexpected behavior, and establish observational signatures for the space community are presented. The various device configurations found in space-related laboratory investigations are outlined

Ensemble learning frameworks for the discovery of multi-component quantitative models in biomedical applications

Abstrac

Perioperative Quality Initiative (POQI) consensus statement on the physiology of blood pressure control as applied to perioperative medicine.

Background: A multi-disciplinary, international working subgroup of the Third Perioperative Quality Initiative (POQI) consensus meeting reviewed the (patho)physiology and measurement of arterial blood pressure (ABP), as applied to perioperative medicine. Methods: We addressed predefined questions by undertaking a modified Delphi analysis, in which primary clinical research and review articles were identified using MEDLINE. Strength of recommendations, where applicable, were graded by NICE guidelines. Results: Perioperative ABP management is a physiologically-complex challenge influenced by multiple factors: (i) ABP is the input pressure to organ blood flow, but is not the sole determinant of perfusion pressure; (ii) blood flow is often independent of changes in perfusion pressure, due to autoregulatory changes in vascular resistance; (iii) microvascular dysfunction uncouples microvascular blood flow from ABP (haemodynamic incoherence) From a practical clinical perspective, we identified that: (i) ambulatory measurement is the optimal method to establish baseline ABP; (ii) automated and invasive ABP measurements have inherent physiological and technical limitations; (iii) individualised ABP targets may change over time, especially during the perioperative period. There remains a need for research in non-invasive, continuous arterial pressure measurements, macro- and microcirculatory control, regional perfusion pressure measurement and the development of sensitive, specific and continuous measures of cellular function to evaluate blood pressure management in a physiologically coherent manner. Conclusion: The multivariable, complex physiology contributing to dynamic changes in perioperative ABP may be underappreciated clinically. The frequently unrecognised dissociation between ABP, organ blood flow, microvascular and cellular function requires further research that develops a more refined, contextualized clinical approach to this routine measurement

Interrelationship between Lab, Space, Astrophysical, Magnetic Fusion, and Inertial Fusion Plasma Experiments

The objectives of this review are to articulate geospace, heliospheric, and astrophysical plasma physics issues that are addressable by laboratory experiments, to convey the wide range of laboratory experiments involved in this interdisciplinary alliance, and to illustrate how lab experiments on the centimeter or meter scale can develop, through the intermediary of a computer simulation, physically credible scaling of physical processes taking place in a distant part of the universe over enormous length scales. The space physics motivation of laboratory investigations and the scaling of laboratory plasma parameters to space plasma conditions, having expanded to magnetic fusion and inertial fusion experiments, are discussed. Examples demonstrating how laboratory experiments develop physical insight, validate or invalidate theoretical models, discover unexpected behavior, and establish observational signatures for the space community are presented. The various device configurations found in space-related laboratory investigations are outlined