The Iowa Homemaker vol.21, no.7

Spreads, Marijean Feik, page 1 Exam Checks on Seniors, Ann Koebel, page 2 Home Demonstration Proves Its Worth, Marghetta Jebson, page 3 Knit and Save, Catherine Tidemanson, page 4 Skills Enter Free Lancing, Doris McCray, page 5 What’s New in Home Economics, Dorothy Olson, page 6 Midseason Sparkle for Sally, Pauline McMahon, page 8 Departmental Highlights, Lila Williamson, page 10 Visual Education Gains Scope, Betty Ann Iverson, page 12 Ingenuity Saves Cosmetics, Betty Roth, page 13 Across Alumnae Desks, Marjorie Thomas, page 14 Bookmarks, Julie Wendel, page 15 Women’s Day, Margaret Anne Clark, page 16 Alums in the News, Bette Simpson, page 1

The Iowa Homemaker vol.22, no.2

Keeping Up With Today, Barbara Sgarlata, page 4 Women Score Dating, Julie Wendel, page 5 The Union Feeds the Navy, Betty Ann Iverson, page 6 Glass in Uniform, Dorothy Walker, page 7 Sugar Problem – A Challenge, Anne Koebel, page 8 Enter: Variety in Army Menus, Mary Schmidt, page 10 “Is It All Wool?”, Margaret Anne Clark, page 11 America Conserves Equpment, Bette Simpson, page 12 Morale on a Budget, Pat Hayes, page 14 What’s New in Home Economics, Ruth Vogel, page 16 Bookmarks, Eileen Dudgeon, page 18 Isabelle Bevier - Pioneer, Dorothy Ann Olson, page 20 Alums in the News, Harriet Zook, page 22 Our Part in the War, Virginia Bates, page 23 Iowa Goes “All Out”, Catherine Tidemanson, page 24 Tim Must S-t-r-e-t-c-h, Doris Plagge, page 26 Vanilla Joins Shortage Ranks, Grace Brown, page 28 Her Champion Pie, Pat Galligan, page 29 Across Alumnae Desks, Mary Ellen Sullivan, page 30 Speaking of Veishea, Trymby Calhoun, page 3

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

Cancer immunoediting is the process whereby immune cells protect against cancer formation by sculpting the immunogenicity of developing tumors. Although the full process depends on innate and adaptive immunity, it remains unclear whether innate immunity alone is capable of immunoediting. To determine whether the innate immune system can edit tumor cells in the absence of adaptive immunity, we compared the incidence and immunogenicity of 3'methylcholanthrene-induced sarcomas in syngeneic wild-type, RAG2, and RAG2x γc mice. We found that innate immune cells could manifest cancer immunoediting activity in the absence of adaptive immunity. This activity required natural killer (NK) cells and interferon γ (IFN-γ), which mediated the induction of M1 macrophages. M1 macrophages could be elicited by administration of CD40 agonists, thereby restoring editing activity in RAG2x γc mice. Our results suggest that in the absence of adaptive immunity, NK cell production of IFN-γ induces M1 macrophages, which act as important effectors during cancer immunoediting

Immune-mediated dormancy: An equilibrium with cancer

This brief review discusses the role of the immune system in tumor development, covering a history of cancer immunity and a summary of the concept of cancer immunoediting, including its three phases: elimination, equilibrium, and escape. The latter half of this review then focuses specifically on the equilibrium phase, making note of previous work, suggesting that immunity might maintain cancer in a dormant state, and concluding with a description of a tractable mouse model unequivocally demonstrating that immunity can indeed hold preformed cancer in check. These findings form a framework for future studies aimed at validating immune-mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer

Adaptive immunity maintains occult cancer in an equilibrium state

The capacity of immunity to control and shape cancer, that is, cancer immunoediting, is the result of three processes that function either independently or in sequence: elimination (cancer immunosurveillance, in which immunity functions as an extrinsic tumour suppressor in naive hosts); equilibrium (expansion of transformed cells is held in check by immunity); and escape (tumour cell variants with dampened immunogenicity or the capacity to attenuate immune responses grow into clinically apparent cancers). Extensive experimental support now exists for the elimination and escape processes because immunodeficient mice develop more carcinogen-induced and spontaneous cancers than wild-type mice, and tumour cells from immunodeficient mice are more immunogenic than those from immunocompetent mice. In contrast, the equilibrium process was inferred largely from clinical observations, including reports of transplantation of undetected (occult) cancer from organ donor into immunosuppressed recipients. Herein we use a mouse model of primary chemical carcinogenesis and demonstrate that equilibrium occurs, is mechanistically distinguishable from elimination and escape, and that neoplastic cells in equilibrium are transformed but proliferate poorly in vivo. We also show that tumour cells in equilibrium are unedited but become edited when they spontaneously escape immune control and grow into clinically apparent tumours. These results reveal that, in addition to destroying tumour cells and sculpting tumour immunogenicity, the immune system of a naive mouse can also restrain cancer growth for extended time periods

The Iowa Homemaker vol.21, no.7

Spreads, Marijean Feik, page 1 Exam Checks on Seniors, Ann Koebel, page 2 Home Demonstration Proves Its Worth, Marghetta Jebson, page 3 Knit and Save, Catherine Tidemanson, page 4 Skills Enter Free Lancing, Doris McCray, page 5 What’s New in Home Economics, Dorothy Olson, page 6 Midseason Sparkle for Sally, Pauline McMahon, page 8 Departmental Highlights, Lila Williamson, page 10 Visual Education Gains Scope, Betty Ann Iverson, page 12 Ingenuity Saves Cosmetics, Betty Roth, page 13 Across Alumnae Desks, Marjorie Thomas, page 14 Bookmarks, Julie Wendel, page 15 Women’s Day, Margaret Anne Clark, page 16 Alums in the News, Bette Simpson, page 17</p

Cancer immunoediting by the innate immune system in the absence of adaptive immunity.

Cancer immunoediting is the process whereby immune cells protect against cancer formation by sculpting the immunogenicity of developing tumors. Although the full process depends on innate and adaptive immunity, it remains unclear whether innate immunity alone is capable of immunoediting. To determine whether the innate immune system can edit tumor cells in the absence of adaptive immunity, we compared the incidence and immunogenicity of 3'methylcholanthrene-induced sarcomas in syngeneic wild-type, RAG2(-/-), and RAG2(-/-)x γc(-/-) mice. We found that innate immune cells could manifest cancer immunoediting activity in the absence of adaptive immunity. This activity required natural killer (NK) cells and interferon γ (IFN-γ), which mediated the induction of M1 macrophages. M1 macrophages could be elicited by administration of CD40 agonists, thereby restoring editing activity in RAG2(-/-)x γc(-/-) mice. Our results suggest that in the absence of adaptive immunity, NK cell production of IFN-γ induces M1 macrophages, which act as important effectors during cancer immunoediting