A Systematic Search of Distant Superclusters with the Subaru Hyper Suprime-Cam Survey

Superclusters, encompassing environments across a wide range of overdensities, can be regarded as unique laboratories for studying galaxy evolution. Although numerous supercluster catalogs have been published, none of them goes beyond redshift $z=0.7$. In this work, we adopt a physically motivated supercluster definition, requiring that superclusters should eventually collapse even in the presence of dark energy. Applying a friends-of-friends (FoF) algorithm to the CAMIRA cluster sample constructed using the Subaru Hyper Suprime-Cam survey data, we have conducted the first systematic search for superclusters at $z=0.5-1.0$ and identified $633$ supercluster candidates over an area of 1027 deg$^2$. The FoF algorithm is calibrated by evolving $N$-body simulations to the far future to ensure high purity. We found that these high-$z$ superclusters are mainly composed of $2-4$ clusters, suggesting the limit of gravitationally bound structures in the younger Universe. In addition, we studied the properties of the clusters and brightest cluster galaxies (BCGs) residing in different large-scale environments. We found that clusters associated with superclusters are typically richer, but no apparent dependence of the BCG properties on large-scale structures is found. We also compared the abundance of observed superclusters with mock superclusters extracted from halo light cones, finding that photometric redshift uncertainty is a limiting factor in the performance of superclusters detection.Comment: Submitted to ApJ. 29 pages, 22 figures, 6 table

The Mass Structure of the Galaxy Cluster Cl0024+1654 from a Full Lensing Analysis of Joint Subaru and ACS/NIC3 Observations

We derive an accurate mass distribution of the rich galaxy cluster Cl0024+1654 (z=0.395) based on deep Subaru BR_{c}z' imaging and our recent comprehensive strong lensing analysis of HST/ACS/NIC3 observations. We obtain the weak lensing distortion and magnification of undilted samples of red and blue background galaxies by carefully combining all color and positional information. Unlike previous work, the weak and strong lensing are in excellent agreement where the data overlap. The joint mass profile continuously steepens out to the virial radius with only a minor contribution \sim 10% in the mass from known subcluster at a projected distance of \sim 700kpc/h. The projected mass distribution for the entire cluster is well fitted with a single Navarro-Frenk-White model with a virial mass, M_{vir} = (1.2 \pm 0.2) \times 10^{15} M_{sun}/h, and a concentration, c_{vir} = 9.2^{+1.4}_{-1.2}. This model fit is fully consistent with the depletion of the red background counts, providing independent confirmation. Careful examination and interpretation of X-ray and dynamical data strongly suggest that this cluster system is in a post collision state, which we show is consistent with our well-defined mass profile for a major merger occurring along the line of sight, viewed approximately 2-3Gyr after impact when the gravitational potential has had time to relax in the center, before the gas has recovered and before the outskirts are fully virialized. Finally, our full lensing analysis provides a model-independent constraint of M_{2D}(<r_{vir}) = (1.4 \pm 0.3) \times 10^{15} M_{sun}/h for the projected mass of the whole system, including any currently unbound material beyond the virial radius, which can constrain the sum of the two pre-merger cluster masses when designing simulations to explore this system.Comment: Accepted by ApJ; 35 pages, 25 figures; including gNFW fit results (Section 5.1), simulated post-shock temperatures consistent with X-ray results using T_{sl} (Section 7.3); Figures 7, 16, 24 added; a version with high resolution figures available at http://www.asiaa.sinica.edu.tw/~keiichi/upfiles/CL0024/ms_highreso.pd

A System for Worldwide COVID-19 Information Aggregation

The global pandemic of COVID-19 has made the public pay close attention to related news, covering various domains, such as sanitation, treatment, and effects on education. Meanwhile, the COVID-19 condition is very different among the countries (e.g., policies and development of the epidemic), and thus citizens would be interested in news in foreign countries. We build a system for worldwide COVID-19 information aggregation (http://lotus.kuee.kyoto-u.ac.jp/NLPforCOVID-19 ) containing reliable articles from 10 regions in 7 languages sorted by topics for Japanese citizens. Our reliable COVID-19 related website dataset collected through crowdsourcing ensures the quality of the articles. A neural machine translation module translates articles in other languages into Japanese. A BERT-based topic-classifier trained on an article-topic pair dataset helps users find their interested information efficiently by putting articles into different categories.Comment: Poster on NLP COVID-19 Workshop at ACL 2020, 4 pages, 3 figures, 7 table

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

Differing Dynamics of Intrapersonal and Interpersonal Coordination: Two-finger and Four-Finger Tapping Experiments.

Finger-tapping experiments were conducted to examine whether the dynamics of intrapersonal and interpersonal coordination systems can be described equally by the Haken-Kelso-Bunz model, which describes inter-limb coordination dynamics. This article reports the results of finger-tapping experiments conducted in both systems. Two within-subject factors were investigated: the phase mode and the number of fingers. In the intrapersonal experiment (Experiment 1), the participants were asked to tap, paced by a gradually hastening auditory metronome, looking at their fingers moving, using the index finger in the two finger condition, or the index and middle finger in the four-finger condition. In the interpersonal experiment (Experiment 2), pairs of participants performed the task while each participant used the outside hand, tapping with the index finger in the two finger condition, or the index and middle finger in the four-finger condition. Some results did not agree with the HKB model predictions. First, from Experiment 1, no significant difference was observed in the movement stability between the in-phase and anti-phase modes in the two finger condition. Second, from Experiment 2, no significant difference was found in the movement stability between the in-phase and anti-phase mode in the four-finger condition. From these findings, different coordination dynamics were inferred between intrapersonal and interpersonal coordination systems against prediction from the previous studies. Results were discussed according to differences between intrapersonal and interpersonal coordination systems in the availability of perceptual information and the complexity in the interaction between limbs derived from a nested structure

%Recurrence.

<p>Circle marker/rigid line represents two-finger in-phase condition, 2f-in; Triangle marker/rigid line represents two-finger anti-phase condition, 2f-an; Circle marker/dashed line represents four-finger in-phase condition, 4f-in; Triangle marker/dashed line represents four-finger anti-phase condition, 4f-an. Error bars represent the standard deviation.</p

SD of relative phase.

<p>Circle marker/rigid line represents two-finger in-phase condition, 2f-in; Triangle marker/rigid line represents two-finger anti-phase condition, 2f-an; Circle marker/dashed line represents four-finger in-phase condition, 4f-in; Triangle marker/dashed line represents four-finger anti-phase condition, 4f-an. Error bars represent the standard deviation.</p