On Heat-Treatable Copper-Chromium Alloy, 1

A mother alloy of 10% Cr and 90% Cu was prepared by sintering. This was alloyed with the Cu melt and Cu-Cr alloys containing about 0.5% Cr was obtained. These alloys could be deformed easily in both the hot and cold states. By measuring the hardness change, age-hardening properties of cast alloys were studied, which were quenched from 950 deg and aged at 300 to 700 deg for 1 hour. The maximum hardness was obtained with the tempering temperature of 500 deg. For the temperature of solution-treatment, 950 deg was insufficient and that above 1000 deg necessary. For the tempering time, a treatment at 500 deg for 1 hr. or at 450 deg for 3 hrs. yielded the maximum hardness. As for the properties for electrical conductors, 3 kinds of wires (diam. 2 mm.) were made: (1) after cold-drawn to 2 mm., solution-treated, quenched, and then tempered (500 deg, 1 hr.); (2) after quenching, cold-drawn (75% reduction) to 2 mm. and tempered (500 deg, 1 hr.); and (3) after quenching, cold-drawn (81%) to intermediate diameter, tempered (500 deg, 1 hr.) and then cold-drawn (88%) again. Properties obtained for the 3 kinds, respectively, were as follows: conductivity 91, 90, and 86%. Tensile strength and strength for electrical conductivity are given

A Water Maser and Ammonia Survey of GLIMPSE Extended Green Objects (EGOs)

We present the results of a Nobeyama 45-m water maser and ammonia survey of all 94 northern GLIMPSE Extended Green Objects (EGOs), a sample of massive young stellar objects (MYSOs) identified based on their extended 4.5 micron emission. We observed the ammonia (1,1), (2,2), and (3,3) inversion lines, and detect emission towards 97%, 63%, and 46% of our sample, respectively (median rms ~50 mK). The water maser detection rate is 68% (median rms ~0.11 Jy). The derived water maser and clump-scale gas properties are consistent with the identification of EGOs as young MYSOs. To explore the degree of variation among EGOs, we analyze subsamples defined based on MIR properties or maser associations. Water masers and warm dense gas, as indicated by emission in the higher-excitation ammonia transitions, are most frequently detected towards EGOs also associated with both Class I and II methanol masers. 95% (81%) of such EGOs are detected in water (ammonia(3,3)), compared to only 33% (7%) of EGOs without either methanol maser type. As populations, EGOs associated with Class I and/or II methanol masers have significantly higher ammonia linewidths, column densities, and kinetic temperatures than EGOs undetected in methanol maser surveys. However, we find no evidence for statistically significant differences in water maser properties (such as maser luminosity) among any EGO subsamples. Combining our data with the 1.1 mm continuum Bolocam Galactic Plane Survey, we find no correlation between isotropic water maser luminosity and clump number density. Water maser luminosity is weakly correlated with clump (gas) temperature and clump mass.Comment: Astrophysical Journal, accepted. Emulateapj, 24 pages including 24 figures, plus 9 tables (including full content of online-only tables

Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli

PURPOSE: Recent in vitro studies suggested that the autocrine leptin loop might contribute to breast cancer development by enhancing cell growth and survival. To evaluate whether the leptin system could become a target in breast cancer therapy, we examined the expression of leptin and its receptor (ObR) in primary and metastatic breast cancer and noncancer mammary epithelium. We also studied whether the expression of leptin/ObR in breast cancer can be induced by obesity-related stimuli, such as elevated levels of insulin, insulin-like growth factor-I (IGF-I), estradiol, or hypoxic conditions. EXPERIMENTAL DESIGN: The expression of leptin and ObR was examined by immunohistochemistry in 148 primary breast cancers and 66 breast cancer metastases as well as in 90 benign mammary lesions. The effects of insulin, IGF-I, estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines. RESULTS: Leptin and ObR were significantly overexpressed in primary and metastatic breast cancer relative to noncancer tissues. In primary tumors, leptin positively correlated with ObR, and both biomarkers were most abundant in G3 tumors. The expression of leptin mRNA was enhanced by insulin and hypoxia in MCF-7 and MDA-MB-231 cells, whereas IGF-I and estradiol stimulated leptin mRNA only in MCF-7 cells. ObR mRNA was induced by insulin, IGF-I, and estradiol in MCF-7 cells and by insulin and hypoxia in MDA-MB-231 cells. CONCLUSIONS: Leptin and ObR are overexpressed in breast cancer, possibly due to hypoxia and/or overexposure of cells to insulin, IGF-I, and/or estradiol

The relationships between hypoxia-dependent markers: HIF-1alpha, EPO and EPOR in colorectal cancer

Abstract: Hypoxia triggers production of several cytoprotective proteins. Hypoxia-inducible factor 1alpha (HIF-1α) is a powerful stimulator of transcription of many genes, including erythropoietin (EPO) in hypoxia-affected cells. Recent data have also implicated signaling by EPO receptor (EPOR) as a new factor influencing tumor progression. The aim of the study was to detect by immunohistochemistry the presence of HIF-1α, EPO and EPOR in colorectal cancer (CRC) in reference to clinicopathological variables. We found the presence of the studied proteins in specimens of all 125 CRC patients which is suggestive of the occurrence of hypoxia in colorectal cancer tissues. The expression of HIF-1α correlated significantly with the presence of EPO and EPOR in all samples (P < 0.001, r = 0.549 and P < 0.001, r = 0.536, respectively). Significant correlations (from P < 0.024 to P < 0.001) were found in the analyses of CRC subgroups such as histopathological type tumor, tumor grade, tumor stage and patients with lymph nodes metastases. The same high significant correlations (P < 0.001) were observed in group of sex, age and tumor location. However, the values of the correlation coefficients (r) which usually ranged from 0.5 to 0.6 suggest the existence of independent or concurrent mechanism stimulating generation of these proteins in colorectal cancer

Inorganic synthesis-structure maps in zeolites with machine learning and crystallographic distances

Zeolites are inorganic materials known for their diversity of applications, synthesis conditions, and resulting polymorphs. Although their synthesis is controlled both by inorganic and organic synthesis conditions, computational studies of zeolite synthesis have focused mostly on organic template design. In this work, we use a strong distance metric between crystal structures and machine learning (ML) to create inorganic synthesis maps in zeolites. Starting with 253 known zeolites, we show how the continuous distances between frameworks reproduce inorganic synthesis conditions from the literature without using labels such as building units. An unsupervised learning analysis shows that neighboring zeolites according to our metric often share similar inorganic synthesis conditions, even in template-based routes. In combination with ML classifiers, we find synthesis-structure relationships for 14 common inorganic conditions in zeolites, namely Al, B, Be, Ca, Co, F, Ga, Ge, K, Mg, Na, P, Si, and Zn. By explaining the model predictions, we demonstrate how (dis)similarities towards known structures can be used as features for the synthesis space. Finally, we show how these methods can be used to predict inorganic synthesis conditions for unrealized frameworks in hypothetical databases and interpret the outcomes by extracting local structural patterns from zeolites. In combination with template design, this work can accelerate the exploration of the space of synthesis conditions for zeolites

Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy

<p>Abstract</p> <p>Background</p> <p>Tumor hypoxia is marked by enhanced expression of hypoxia-inducible factor-α (HIF-1α) and glucose transporter-1 (Glut-1). Hypoxic conditions have also been associated with overexpression of angiogenic factors, such as leptin. The aim of our study was to analyze the relationships between hypoxia markers HIF-1α, Glut-1, leptin, leptin receptor (ObR) and other breast cancer biomarkers in primary and metastatic breast cancer in patients treated or untreated with preoperative chemotherapy.</p> <p>Methods</p> <p>The expression of different biomarkers was examined by immunohistochemistry in 116 primary breast cancers and 65 lymph node metastases. Forty five of these samples were obtained form patients who received preoperative chemotherapy and 71 from untreated patients.</p> <p>Results</p> <p>In primary tumors without preoperative chemotherapy, HIF-1α and Glut-1 were positively correlated (p = 0.02, r = 0.437). HIF-1α in primary and metastatic tumors without preoperative therapy positively correlated with leptin (p < 0.0001, r = 0.532; p = 0.013, r = 0.533, respectively) and ObR (p = 0.002, r = 0.319; p = 0.083, r = 0.387, respectively). Hypoxia markers HIF-1α and Glut-1 were negatively associated with estrogen receptor alpha (ERα) and positively correlated with estrogen receptor beta (ERβ). In this group of tumors, a positive correlation between Glut-1 and proliferation marker Ki-67 (p = 0.017, r = 0.433) was noted. The associations between HIF-1α and Glut-1, HIF-1α and leptin, HIF-1α and ERα as well as Glut-1 and ERβ were lost following preoperative chemotherapy.</p> <p>Conclusions</p> <p>Intratumoral hypoxia in breast cancer is marked by coordinated expression of such markers as HIF-1α, Glut-1, leptin and ObR. The relationships among these proteins can be altered by preoperative chemotherapy.</p

Multi-Transition Study of M51's Molecular Gas Spiral Arms

Two selected regions in the molecular gas spiral arms in M51 were mapped with the Owens Valley Radio Observatory (OVRO) mm-interferometer in the 12CO(2-1), 13CO(1-0), C18O(1-0), HCN(1-0) and HCO+(1-0) emission lines. The CO data have been combined with the 12CO(1-0) data from Aalto et al. (1999) covering the central 3.5kpc to study the physical properties of the molecular gas. All CO data cubes were short spacing corrected using IRAM 30m (12CO(1-0): NRO 45m) single dish data. A large velocity gradient (LVG) analysis finds that the giant molecular clouds (GMCs) are similar to Galactic GMCs when studied at 180pc (120pc) resolution with an average kinetic temperature of T_kin = 20(16)K and H_2 density of n(H_2) = 120(240)cm^(-3) when assuming virialized clouds (a constant velocity gradient dv/dr. The associated conversion factor between H_2 mass and CO luminosity is close to the Galactic value for most regions analyzed. Our findings suggest that the GMC population in the spiral arms of M51 is similar to those of the Milky Way and therefore the strong star formation occurring in the spiral arms has no strong impact on the molecular gas in the spiral arms. Extinction inferred from the derived H_2 column density is very high (A_V about 15 - 30 mag), about a factor of 5-10 higher than the average value derived toward HII regions. Thus a significant fraction of the ongoing star formation could be hidden inside the dust lanes of the spiral arms. A comparison of MIPS 24um and H_alpha data, however, suggests that this is not the case and most of the GMCs studied here are not (yet) forming stars. We also present low (4.5") resolution OVRO maps of the HCN(1-0) and HCO+(1-0) emission at the location of the brightest 12CO(1-0) peak.Comment: 41 pages, 12 figures, 7 tables; accepted for publication by Ap

A Water Maser and NH_3 Survey of GLIMPSE Extended Green Objects

We present the results of a Nobeyama 45 m H_(2)O maser and NH_3 survey of all 94 northern GLIMPSE extended green objects (EGOs), a sample of massive young stellar objects (MYSOs) identified based on their extended 4.5 μm emission. We observed the NH3(1,1), (2,2), and (3,3) inversion lines, and detected emission toward 97%, 63%, and 46% of our sample, respectively (median rms ~ 50 mK). The H_(2)O maser detection rate is 68% (median rms ~ 0.11 Jy). The derived H_(2)O maser and clump-scale gas properties are consistent with the identification of EGOs as young MYSOs. To explore the degree of variation among EGOs, we analyze subsamples defined based on mid-infrared (MIR) properties or maser associations. H_(2)O masers and warm dense gas, as indicated by emission in the higher-excitation NH_3 transitions, are most frequently detected toward EGOs also associated with both Class I and II CH_(3)OH masers. Ninety-five percent (81%) of such EGOs are detected in H_(2)O (NH_(3)(3,3)), compared to only 33% (7%) of EGOs without either CH_(3)OH maser type. As populations, EGOs associated with Class I and/or II CH3OH masers have significantly higher NH_3 line widths, column densities, and kinetic temperatures than EGOs undetected in CH_(3)OH maser surveys. However, we find no evidence for statistically significant differences in H_(2)O maser properties (such as maser luminosity) among any EGO subsamples. Combining our data with the 1.1 mm continuum Bolocam Galactic Plane Survey, we find no correlation between isotropic H_(2)O maser luminosity and clump number density. H_(2)O maser luminosity is weakly correlated with clump (gas) temperature and clump mass