Comparison of Survival Rates, Tumor Stages, and Localization in between Obese and Nonobese Patients with Gastric Cancer

Purpose. In this study we tried to determine the association between body-mass index (BMI), survival rate, and the stage of tumor at the time of diagnosis in patients with gastric cancer. Methods. A total of 270 gastric cancer patients’ hospital records were retrospectively evaluated. Patients were grouped according to their BMI at the time of tumor diagnosis. Tumor stages at admission were compared according to their BMI values. Results. There were no differences in OS among BMI subgroups (p=0.230). The percent of patients with stage III tumor was significantly higher in nonobese while the percent of stage IV tumor was surprisingly higher in obese patients (p was 0.011 and 0.004, resp.). Percent of patients who did not have any surgical intervention was significantly lower in overweight and obese patients than normal and/or underweight patients. Conclusions. At the time of diagnosis, obese patients had significantly higher percent of stage IV tumor than nonobese patients. Despite of that, there were no differences in survival rates among BMI subgroups. Our study results are consistent with “obesity paradox” in gastric cancer patients. We also did not find any relationship between BMI and localization of gastric tumor

The Impact Of Comprehensive School Nursing Services On Students' Academic Performance

Introduction: School nursing services should be evaluated through health and academic outcomes of students; however, it is observed that the number of studies in this field is limited. The aim of this study is to evaluate the impact of comprehensive school nursing services provided to 4th grade primary school students on academic performance of students., Methods: The quasi-experimental study was conducted with 31 students attending a randomly selected school in economic disadvantaged area in Turky. Correlation analysis, repeated measures analyses of variance, multiple regression analysis were used to analyze the data with SPSS software., Results: At the end of school nursing practices, an increase was occurred in students’ academic achievement grades whereas a decrease was occurred in absenteeism and academic procrastination behaviors. Whilst it was determined that nursing interventions including treatment/ procedure and surveillance was associated to the decrease of absenteeism, it also was discovered that the change in the health status of the student after nursing interventions was related to the increase of the academic achievement grade and the decrease of the academic procrastination behavior score. , Conclusion: In this study, the conclusion that comprehensive school nursing services contributed positively to the academic performance of students has been reached. In addition, it can be suggested that effective school nursing services should include services such as acute-chronic disease treatment, first aid, health screening, health improvement-protection, health education, guidance and counseling and case management.PubMe

Use of Simulation in Nursing Education : Initial Experiences on a European Union Lifelong Learning Programme - Leonardo da Vinci Project

This work is licensed under a Creative Commons Attribution 3.0 LicenseAim: The aim of this paper is to share the initial experiences on a European Union (EU) Lifelong Learning Programme Leonardo Da Vinci Transfer of Innovation Project related to the use of simulation-based learning with nursing students from Turkey. The project started at the end of the 2010 involving 7 partners from 3 different countries including Turkey, England, and Italy. Methods: This project is divided into 7 work packages (WP). In this paper, experiences from the first three WPs (WP1: Preparation and dissemination of the project. WP2: Regulation of the project management. WP3: Development of the evaluation tools used to evaluate the impact of the innovative practice within the coordinating partner's institution) are shared. Results: In the WP1 and WP2: the kick-off meeting was organized in Turkey, the coordinating partner’s country. During the meeting project-related events were planned and the steering committee of the project was formed. A strong team spirit within the partnership was established. For the dissemination of the project, a poster and flier of the project were prepared and placed on corporate boards visible to students and teaching staff and put on the partners’ institutional websites. Regular bulletins of the project were also prepared and posted on the project website. In the WP3, student data sheet, items for students’ satisfaction questionnaire and confidence scale were created based on the literature. Trauma patient scenarios (abdominal trauma, thoracic trauma, pelvic fracture and traumatic amputation) were created to test the target group's knowledge. Ethical approval was obtained from the coordinating partner institution. A pilot study to test the cases was conducted. Following the pilot study, the final version of the student data sheet and scenario cases was created. The second meeting was organized in Italy. In this meeting, the results of the pilot study, the scenario cases, and the Patient Intervention Self Confidence /Competence Scale were evaluated. Conclusion: The work on this EU project is still in progress. Considering that learning from experience is an important part of nursing education, sharing experiences on such a project related to using simulation as an innovative teaching strategy in nursing education in Turkey should provide an example to others who want to develop other EU projects in nursing education.Peer reviewedFinal Published versio

Geriatric Assessment In Oncology: G8 Screening Too Validation And Reliability Study

OBJECTIVE The present study aimed to test the validity and reliability of the Geriatrics 8 (G8) tool, a risk-screening tool for further comprehensive geriatric assessment, with hematologic cancer patients aged 65 years and older. METHODS This methodological study included 110 patients followed up for hematologic cancer. Data were collected using the patient identification form, the G8 screening tool, and the Edmonton Frail Scale. Language and content validity, internal consistency, confirmatory factor, sensitivity and specificity and concurrent validity analyses were also used. RESULTS Patients (mean age: 73.9 +/- 6.10) were diagnosed with lymphoma (30.9%), multiple mycloma (21.8%), leukemia (20.9%), myelodysplastic syndrome (19.1%). Confirmatory factor model fit index analysis chi(2)/df and p-values (0.14) showed a good fit and GFI, AGFI, SRMR, and RMSEA values showed acceptable fit. The Cronbach's alpha coefficient was 0.655, area under the ROC curve was 0.824 (95%, 0.745-0.904), and sensitivity and specificity were 61.0% and 88.9%, respectively. CONCLUSION The findings indicated that the G8 screening tool was found a valid and reliable tool for geriatric patients diagnosed with cancer to determine the risk and need for further comprehensive geriatric assessment.WoSScopu

Determinants of physical activity level of people living in rural areas according to the transtheoretical model: regression and path analysis

Introduction: This study investigates the relationship between the physical activities of adults living in rural areas and each component of the Transtheoretical Model. Methods: This descriptive and relational study was conducted with 315 individuals at a rural clinic in Turkey. Data were collected using tools for evaluating the Transtheoretical Model, and the International Physical Activity Questionnaire. Logistic regression analysis, multiple regression analysis, and path analysis were used in statistical analyses. Results: Of the individuals living in rural areas, 59.1% were inactive, and 42.4% of the individuals were in the precontemplation stage. The mean exercise self-efficacy score was low, and pros subdimension of decisional balance was at an insufficient level. According to path analysis, perceived self-efficacy and stage of change for exercise were the variables that had a significant effect on physical activity (the metabolic equivalent of task score). Conclusion: The Transtheoretical Model is a strategic approach to improving exercise behavior in rural areas, and the prerequisites of health promotion such as enhancing education, income, and opportunities will contribute to the popularization of exercise

Adjuvant chemotherapy for gastric cancer in elderly patients has same benefits as in younger patients.

The age-adjusted mortality rate due to gastric cancer was reported to increase with age. This study aims to investigate the results of adjuvant chemotherapy in patients aged 65 years or older comparing with younger patients and focusing on its impact on survival

Clinical efficacy and drug resistance of anti-epidermal growth factor receptor therapy in colorectal cancer

Colorectal cancer (CRC) ranked third in cancer related death and its incidence has been increasing worldwide. In recent decades important therapeutic advances have been developed in treatment of metastatic CRC (mCRC), such as monoclonal antibodies against epidermal growth factor receptor (anti-EGFR), which provided additional clinical benefits in mCRC. However, anti-EGFR therapies have limited usage due to approximately 95\% of patients with KRAS mutated mCRC do not response to anti-EGFR treatment. Thus, KRAS mutation is predictive of nonresponse to anti-EGFR therapies but it alone is not a sufficient basis to decide who should not be received such therapies because; approximately fifty percent (40\%-60\%) of CRC patients with wild-type KRAS mutation also have poor response to anti-EGFR based treatment. This fact leads us to suspect that there must be other molecular determinants of response to anti-EGFR therapies which have not been identified yet. Current article summarizes the clinical efficacy of anti-EGFR therapies and also evaluates its resistance mechanisms

Adjuvant chemotherapy for gastric cancer in elderly patients has same benefits as in younger patients

Objective: The age-adjusted mortality rate due to gastric cancer was reported to increase with age. This study aims to investigate the results of adjuvant chemotherapy in patients aged 65 years or older comparing with younger patients and focusing on its impact on survival. Materials and Methods: A total of 406 patients with nonmetastatic gastric cancer that consisted of 283 patients younger than 65 years (range: 23-64 years) and 123 patients 65 years of age or older (range: 65-75 years) were retrospectively evaluated. Categorical and continuous variables were summarized using the descriptive statistics and compared with Chi-square and Mann-Whitney U-tests, respectively. Cancer-specific survival rates were estimated by the Kaplan-Meier method. Results: Median age at diagnosis was 58 years (range: 23-75 years). There was no significant difference in gender, tumor localization in the stomach (cardia/noncardia), tumor histology, perineural invasion, lymphovascular invasion, histopathological characteristics of the tumor, and tumor stage between groups. No significant difference was detected in survival between groups. The median survivals were 20.8 months (range: 17-24.6) in patients younger than 65 years and 19.5 months (range: 14.8-24.1) in patients 65 years of age or older (P = 0.9). Conclusions: We showed that adjuvant chemotherapy in elderly patients with gastric cancer has same effectiveness as nonelderly patients. However, further well-designated prospective studies are needed to confirm these findings

Ventricular bigeminal rhythm associated with trastuzumab: A potential cardiac side effect.

Cardiac side effects of targeted chemotherapy agents are getting more and more important topic nowadays. However, the studies on this topic are limited. Because multiple agent chemotherapy is not a common treatment option, it is hard to establish controlled study groups (as before chemotherapy and after chemotherapy); further, cancer, itself, may cause cardiac side effects and uncertainty of the symptoms may be associated with previous clinical situation before chemotherapy. For all that, we may get information to a certain degree about the side effects of these agents by analyzing case reports. These side effects have a broad spectrum from asymptomatic rhythm alterations to acute cardiac death. In this case report, we aim to discuss asymptomatic ventricular bigeminal rhythm, which is proved by electrocardiography, of our patient during treated by trastuzumab