INTEGRATIVE SEMANTIC MAP AS AN ILLUSTRATIVE AND SCHEMATIC BASIS FOR THE DEVELOPMENT OF A PROFESSIONALLY SIGNIFICANT ENGLISH-LANGUAGE THESAURUS OF THE THEMATIC FIELD “LAW”

The authors of the article consider integrative semantic mapping as an illustrative and schematic basis for the law students’ development of a professionally oriented English-language thesaurus of the topical field “Law”. The aim of the research is to study further development of professional and communicative English-language competence which allows ensuring the implementation of pragmatic and professional communicative tasks in simulated situations of entering into legal relationship by the students. Methodology. The methodological framework for the research is the cognitive and generalizing methods, such as the theoretical analysis of research works in linguodidactics, pedagogy, cognitive linguistics, and the prognostic methods. The research material was an educational and methodological complex on the discipline “Legal English”, used as part of the Bachelor’s degree program 40.03.01 “Jurisprudence”. Results. The paper analyzes an algorithm for the development of abilities and skills of linguo-cognitive processing of professionally significative highly legal English texts of a static nature (for intermediate and upper-intermediate students), and English-language videos of a dynamic nature of the genre “courtroom drama” (for advanced and proficient students) using integrative semantic maps. Analyzing their application features allows us to emphasize their main function, which consists in optimizing the development of information about the law enforcement and legal proceedings in English-speaking countries, necessary for the effective intercultural communication of future practitioners in various branches of law. Conclusion. Forming and developing the English-language thesaurus of a professional lawyer is one of important areas of modern linguodidactics. It has been proved that the optimization of this process has become possible thanks to the use of new learning technologies, in particular, integrative semantic mapping as a tool for verbalization of acquired knowledge, which allows consciously applying cognitively mastered information, competently verbalizing it in intercultural professional communication, preventing and eliminating possible communication failures

Динамика маркеров стресс-реакции при эмболизации маточных артерий

Aim. To estimate immunobiochemical markers of the stress response during uterine artery embolization (UAE), and to assess the connection of the endocrine and immune response with pain severity Materials and мethods: 62 patients (ages 31 to 56) with a diagnosis of multiple symptomatic uterine body fibroids were made EMA, and analgesia was achieved by intravenous injection of narcotic and non-narcotic analgesics. Immunobiochemical profile of the stress reaction was investigated (IL-1, IL-6, TNFα, IL-4, IL-10, C-reactive protein (CRP), adrenocorticotropic hormone (ACTH), cortisol, blood glucose) at four (I ONLY SEE 3-SMT) time points (baseline at 2 hours after occlusion of the uterine arteries, and 24 and 48 hours after surgery). Pain syndrome was assessed using a visual analogue scale (VAS) by means of hemodynamic profile.Results. The occlusion of the uterine arteries and ischemia myoma nodes lead to the development of the stress response, as anincrease in the serum concentration of pro-inflammatory (IL-1, IL-6, TNFα) and anti-inflammatory (IL-4, IL-10) cytokines, CRP, stress hormones (ACTH, cortisol) levels of glucose was observed. Pain of various intensity was recorded in all cases, and 18% of patients experienced marked pain (7 to 10 points on the VAS).Conclusion. The maximum increase in immunobiochemical stress markers coincides with the highest manifestations of pain. The necessity of optimization methods of analgesia when performing EMA with the use of immunobiochemical stress markers as a control reaction taking into account hemodynamic profile and VAS data was observed.Цель исследования. Оценка иммунобиохимических маркеров стресс-реакции при эмболизации маточных артерий (ЭМА), оценка связи выраженности эндокринного и иммунного ответа с выраженностью болевого синдрома.Материал и методы. Пациенткам (n = 62) в возрасте 31–56 лет с диагнозом «симптомная множественная миома тела матки» выполнена ЭМА, анальгезия достигалась внутривенным введением наркотических и ненаркотических анальгетиков. Исследован иммунобиохимический профиль стресс-реакции (IL-1, IL-6, TNFα, IL-4, IL-10, С-реактивный протеин (CRP), адренокортикотропный гормон (АКТГ), кортизол, глюкоза крови) в динамике, на четырех точках контроля (исходный уровень, через 2 ч после окклюзии маточных артерий, через 24 и 48 ч после операции). Болевой синдром оценивался по визуально-аналоговой шкале (ВАШ), с помощью гемодинамического профиля.Результаты. Окклюзия маточных артерий и ишемия в миоматозных узлах ведет к развитию стресс-реакции: увеличение концентрации в сыворотке крови провоспалительных (IL-1, IL-6, TNFα) и противовоспалительных (IL-4, IL-10) цитокинов, CRP, гормонов стресса (АКТГ, кортизола), уровня гликемии. Болевой синдром разной степени интенсивности регистрируется в 100% случаев, 18% пациенток испытывали выраженные болевые ощущения (7–10 баллов по ВАШ).Заключение. Максимальный прирост иммунобиохимических маркеров стресса совпадает по времени с максимальными проявлениями болевого синдрома. Выявлена необходимость оптимизации методов анальгезии при выполнении ЭМА с использованием в качестве контроля иммунобиохимических маркеров стресс-реакции, учитывая гемодинамический профиль и данные ВАШ

Wip1 phosphatase: between p53 and MAPK kinases pathways

IF 5.008International audienceCells undergoing oncogenic transformation frequently inactivate tumor suppressor pathways that could prevent their uncontrolled growth. Among those pathways p53 and p38MAPK pathways play a critical role in regulation of cell cycle, senescence and cell death in response to activation of oncogenes, stress and DNA damage. Consequently, these two pathways are important in determining the sensitivity of tumor cells to anti-cancer treatment. Wild type p53-induced phosphatase, Wip1, is involved in governance of both pathways. Recently, strategies directed to manipulation with Wip1 activity proposed to advance current day anticancer treatment and novel chemical compounds synthesized to improve specificity of manipulation with Wip1 activity. Here we reviewed the history of Wip1 studies in vitro and in vivo, in genetically modified animal models that support Wip1 role in tumorigenesis through regulation of p53 and p38MAPK pathways. Based on our knowledge we propose several recommendations for future more accurate studies of Wip1 interactions with other pathways involved in tumorigenesis using recently developed tools and for adoption of Wip1 manipulation strategies in anti-cancer therapy

Wip1 inhibition leads to severe pro-inflammatory phenotype in skin in response to chemical irritation

IF 3.733Lettre à l'éditeur ("Journal of Dermatological Science" vol. 87, n°1)http://www.sciencedirect.com/science/article/pii/S0923181116309252?via%3Dihu

The dynamics of the stress response markers in uterine artery embolization

Aim. To estimate immunobiochemical markers of the stress response during uterine artery embolization (UAE), and to assess the connection of the endocrine and immune response with pain severity Materials and мethods: 62 patients (ages 31 to 56) with a diagnosis of multiple symptomatic uterine body fibroids were made EMA, and analgesia was achieved by intravenous injection of narcotic and non-narcotic analgesics. Immunobiochemical profile of the stress reaction was investigated (IL-1, IL-6, TNFα, IL-4, IL-10, C-reactive protein (CRP), adrenocorticotropic hormone (ACTH), cortisol, blood glucose) at four (I ONLY SEE 3-SMT) time points (baseline at 2 hours after occlusion of the uterine arteries, and 24 and 48 hours after surgery). Pain syndrome was assessed using a visual analogue scale (VAS) by means of hemodynamic profile.Results. The occlusion of the uterine arteries and ischemia myoma nodes lead to the development of the stress response, as anincrease in the serum concentration of pro-inflammatory (IL-1, IL-6, TNFα) and anti-inflammatory (IL-4, IL-10) cytokines, CRP, stress hormones (ACTH, cortisol) levels of glucose was observed. Pain of various intensity was recorded in all cases, and 18% of patients experienced marked pain (7 to 10 points on the VAS).Conclusion. The maximum increase in immunobiochemical stress markers coincides with the highest manifestations of pain. The necessity of optimization methods of analgesia when performing EMA with the use of immunobiochemical stress markers as a control reaction taking into account hemodynamic profile and VAS data was observed