20 research outputs found
Suggestions for Radiation Oncologists during the COVID-19 Pandemic
SARS-CoV-2 pandemic and COVID-19 diffusion have recently become an international public health emergency. Cancer patients, as a frail population, are particularly exposed to the risk related to infections. The clinical decision-making process and the organizational workflow of radiotherapy department should be revised in the light of the critical situation. We herein provide practical suggestions derived from the available literature and discussed during an online session held within the e-learning educational program of the European School of Oncology on March 31st 2020
Fibrosarcome du larynx - A propos d'un cas
Le fibrosarcome du larynx est une entitĂ© histologique rare, qui reprĂ©sente moins de 10% de tous les sarcomes des tissus mous, moins de 2 % des cancers laryngĂ©s. Cette localisation pose des problĂšmes diagnostique, thĂ©rapeutique et pronostique. Nous prĂ©sentons un cas de fibrosarcome laryngĂ© chez un patient de 54 ans. La confirmation histologique etimmunohistologique a Ă©tĂ© faite sur la piĂšce dâexĂ©rĂšse chirurgicale et surtout sur une confrontation anatomoclinique. La prise en charge thĂ©rapeutique est multidisciplinaire, associant la chirurgie qui doit ĂȘtre la plus complĂšte sans curage ganglionnaire et la radiothĂ©rapie. Le pronostic est gĂ©nĂ©ralement sĂ©vĂšre, dĂ©pend essentiellement de degrĂ© de diffĂ©renciation histologique.Mots clĂ©s : fibrosarcome ; larynx ; chirurgie ; radiothĂ©rapie
Suggestions for Radiation Oncologists during the COVID-19 Pandemic
SARS-CoV-2 pandemic and COVID-19 diffusion have recently become an international public health emergency. Cancer patients, as a frail population, are particularly exposed to the risk related to infections. The clinical decision-making process and the organizational workflow of radiotherapy department should be revised in the light of the critical situation. We herein provide practical suggestions derived from the available literature and discussed during an online session held within the e-learning educational program of the European School of Oncology on March 31st 2020
Carcinome a petites cellules du sinus piriforme : a propos dâune observation.
Les auteurs rapportent un cas de localisation au sinus piriforme dâun carcinome Ă petites cellules. Ce type histologique a Ă©tĂ© souvent dĂ©crit dans la pathologie tumorale pulmonaire. Sa localisation au sinus piriforme Ă©tant exceptionnelle. Nous prĂ©sentons dans ce document les aspects endoscopiques, radiologiques, anatomopathologiques et thĂ©rapeutiques de cette tumeur qui a Ă©tĂ© diagnostiquĂ©e chez un patient de 56 ans.Mots-clĂ©s : Sinus piriforme, carcinome Ă petites cellules, endoscopie, radiologie, anatomopathologie, traitement
The current status of National Cancer Control Plans in Africa: Data from 32 countries
Background: Cancer incidence and mortality are rapidly rising in Africa. National Cancer Control Plans (NCCPs have contributed to a reduction in the burden of some preventable cancers, availing early diagnosis and adequate treatment modalities and palliative care, while sustaining them with sufficient monitoring systems. knowledge we undertook a cross-sectional survey across continental Africa to understand the presence of NCCPs, availability of early detection and screening policies and the status of health financing pertaining to cancer. Methods: Through an online survey, we approached key cancer care staff in 54 countries. Questions were themed in 3 main areas - Cancer registries and national cancer control plans (NCCPs) availability in countries, Cancer screening, diagnosis and management capacity, Financing in cancer care.
Results: On 54 approached respondents, we received 32 responses. 88 % of responding countries have active national cancer registries, 75 % with NCCPs and 47 % with cancer screening policies and practices. Universal Health Coverage is available in 40 % of countries. Conclusion: Our study shows that there is a scarcity of NCCPs in Africa. Deliberate investment in cancer registry and clinical services is key to improving access to care and ultimately reduce cancer mortality in Afric
Angiomyxome agressif de la joue : a propos dâune observation
Lâangiomyxome agressif est une tumeur mĂ©senchymateuse dĂ©veloppĂ©e aux dĂ©pens du tissu conjonctif avec un site de prĂ©dilection pour les parties molles du pĂ©rinĂ© fĂ©minin. Cette tumeur croit progressivement mais nâest pas mĂ©tastatique. Le traitement indiquĂ© actuellement est lâexĂ©rĂšse chirurgicale large sans consĂ©quences fonctionnelles lourdes. La tumeur a une tendance Ă la rĂ©cidive locale, qui est frĂ©quente, liĂ©e Ă la difficultĂ© dâune exĂ©rĂšse initiale complĂšte. Les auteurs rapportent ici le cas dâun angiomyxome agressif de la joue, qui a Ă©tĂ© traitĂ© par chirurgie et chimiothĂ©rapie. Les aspects cliniques, histologiques et thĂ©rapeutiques de la tumeur ont Ă©tĂ© discutĂ©s.Mots-clĂ©s : Lâangiomyxome agressif, tumeur mĂ©senchymateuse, exĂ©rĂšse, rĂ©cidive
Production of recombinant proteins GST L1, E6 and E7 tag HPV 16 for antibody detection of Tunisian cervical cancer patients
In the present work recombinant proteins were produced for used in LUMINEX in order to undergo serological study of Tunisian female population. HPV types 16 L1, E6 and E7 sequences fused to their3â-end to a sequence encoding the terminal undecapeptide of the SV40 large T-antigen (tag) were isolated from plasmids and inserted into a pGEX vector for expression as GST fusion proteins in Escherichia coli. Coding sequences for L1tag, E6tag and E7tag of HPV 16 respectively were mobilized by digestion with enzymes and ligated into digested plasmids downstream of the GST domain. An expression plasmid for GST tag was constructed by inserting a fragment coding for the tag epitope. Data showed that the lysates were stable for detection and they were used in Luminex for detection of antibodies in female Tunisian female patients. This assay showed that the sero-positivity towards thedifferent antigens depends upon the group studied and differences between cases and controls were significant (