13 research outputs found
Enzymatic hydrolysate from velvet antler suppresses adipogenesis in 3T3-L1 cells and attenuates obesity in high-fat diet-fed mice
The purpose of the current study was to investigate the potential anti-obesity activity of an enzymatic hydrolysate of velvet antler in inhibiting adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-fed obese mice. The enzy- matic hydrolysate was prepared using the commercial food grade protease, Protamex. The velvet antler Protamex hydrolysate (VAPH) indicated profound inhibitory effects on adipogenesis dose-dependently by decreasing the accumulation of triglycerides and down-regulating expression levels of adipogenesis-related proteins C/EBPα, SREBP-1, and PPARγ. In a mouse model of HFD-induced obesity, oral administration of VAPH (100 and 300 mg/kg for 13 weeks) significantly reduced the body weight gain that had resulted from the HFD. VAPH treat- ment also lowered the serum glucose and triglyceride levels, while increasing the HDL-C level. Furthermore, the treatment greatly reduced hepatic lipid droplet accumulation as well as the size of adipocytes. Current findings H has profound anti-obesity effects and could be an effective candidate for preventing obesity and obesity-related chronic diseases
Detection of cutaneous HPV types 4 and 24 DNA sequences in breast carcinoma in Singaporean women of Asian ancestry
10.1080/00313020903041002Pathology415436-442PTLG
Genetic testing confirmed the early diagnosis of X-linked hypophosphatemic rickets in a 7-month-old infant
10.1177/2324709615598167Journal of Investigative Medicine High Impact Case Reports3
Genetic testing of GCK-MODY identifies a novel pathogenic variant in a Chinese boy with early onset hyperglycemia
10.1038/s41439-020-0096-0Human Genome Variation71
Simplified Large-Scale Sanger Genome Sequencing for Influenza A/H3N2 Virus
10.1371/journal.pone.0064785PLoS ONE85e6478
Dinucleotide microsatellite repeats are essential for the diagnosis of microsatellite instability in colorectal cancer in Asian patients
World Journal of Gastroenterology11182781-2783WJGA
Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study
10.1016/j.leukres.2006.02.026Leukemia Research31175-8
Development of 2, 7-Diamino-1, 8-Naphthyridine (DANP) Anchored Hairpin Primers for RT-PCR Detection of Chikungunya Virus Infection
10.1371/journal.pntd.0004887PLoS Neglected Tropical Diseases108e000488
Comparison of mutation patterns in full-genome a/H3N2 influenza sequences obtained directly from clinical samples and the same samples after a single MDCK passage
10.1371/journal.pone.0079252PLoS ONE811e7925