Design of ecological heating of a family house

Tato diplomová práce se zabývá návrhem ekologického vytápění pro rodinný dům. Hlavním cílem je nalézt nejvýhodnější variantu systému vytápění a ohřevu teplé vody za pomocí tepelného čerpadla v kooperaci s alternativním systémem ohřevu. Pro vybraný objekt jsou vypočteny tepelné ztráty a na základě toho je zhotoveno několik návrhů vytápění. Následně je vypočtena ekonomická návratnost zhotovených návrhů.This diploma thesis deals with the design of ecological heating for a family house. The main objective is to find the most advantageous variant of the heating and water heating system using a heat pump in cooperation with an alternative heating system. Thermal losses are calculated for the selected object, and several heating designs are made based on the calculations. Then the economic return of the designs is calculated.

Toll-like receptor 2 expression on c-kit + cells tracks the emergence of embryonic definitive hematopoietic progenitors

International audienceHematopoiesis in mammalian embryos proceeds through three successive waves of hema-topoietic progenitors. Since their emergence spatially and temporally overlap and phenotypic markers are often shared, the specifics regarding their origin, development, lineage restriction and mutual relationships have not been fully determined. The identification of wave-specific markers would aid to resolve these uncertainties. Here, we show that toll-like receptors (TLRs) are expressed during early mouse embryogenesis. We provide phenotypic and functional evidence that the expression of TLR2 on E7.5 c-kit + cells marks the emergence of precursors of erythro-myeloid progenitors (EMPs) and provides resolution for separate tracking of EMPs from primitive progenitors. Using in vivo fate mapping, we show that at E8.5 the Tlr2 locus is already active in emerging EMPs and in progenitors of adult hematopoietic stem cells (HSC). Together, this data demonstrates that the activation of the Tlr2 locus tracks the earliest events in the process of EMP and HSC specification