Statistical modelling for prediction of axis-switching in rectangular jets

Rectangular nozzles are increasingly used for modern military aircraft propulsion installations, including the roll nozzles on the F-35B vertical/short take-off and landing strike fighter. A peculiar phenomenon known as axis-switching is generally observed in such non-axisymmetric nozzle flows during which the jet spreads faster along the minor axis compared to the major axis. This might affect the under-wing stores and aircraft structure. A computational fluid dynamics study was performed to understand the effects of changing the upstream nozzle geometry on a rectangular free jet. A method is proposed, involving the formulation of an equation based upon a statistical model for a rectangular nozzle with an exit aspect ratio (ARe) of 4; the variables under consideration (for a constant nozzle pressure ratio (NPR)) being inlet aspect ratio (ARi) and length of the contraction section. The jet development was characterised using two parameters: location of the cross-over point (Xc) and the difference in the jet half-velocity widths along the major and minor axes (ΔB30). Based on the observed results, two statistical models were formulated for the prediction of axis-switching; the first model gives the location of the cross-over point, while the second model indicates the occurrence of axis-switching for the given configuration

Dry-mass sensing for microfluidics

We present an approach for interfacing an electromechanical sensor with a microfluidic device for the accurate quantification of the dry mass of analytes within microchannels. We show that depositing solutes onto the active surface of a quartz crystal microbalance by means of an on-chip microfluidic spray nozzle and subsequent solvent removal provides the basis for the real-time determination of dry solute mass. Moreover, this detection scheme does not suffer from the decrease in the sensor’s quality factor and the viscous drag present if the measurement is performed in a liquid environment, yet allows solutions to be analysed. We demonstrate the sensitivity and reliability of our approach by controlled deposition of nanogram levels of salt and protein from a micrometer-sized channel.We thank Alexander K. Buell, Igor Efimov, and Victor Ostanin for valuable discussions on QCM sensors and gratefully acknowledge financial support from the Swiss National Science Foundation (SNF), the Engineering and Physical Sciences Research Council (EPSRC), the Biotechnology and Biological Sciences Research Council (BBSRC), the European Research Council (ERC), as well as the Frances and Augustus Newman Foundation.Permission is granted to quote from an AIP publication with the customary acknowledgment of the source. Republication of an article or portions thereof (e.g., excerpts of greater than 400 words, figures, tables, etc.) in original form or in translation, as well as other types of reuse (such as use in course packs or electronic reserves) require formal permission from AIP and may be subject to fees. Although it is not a legal requirement for permission, as a courtesy, an author of the original article should be informed of any request for republication/reuse

Desertification

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystem

Effects of upstream nozzle geometry on rectangular free jets

This study is aimed at understanding the effects of changing the upstream nozzle geometry on the development of rectangular free jets. An existing converging rectangular nozzle with an exit aspect ratio of 4 and a circular inlet (AR4 nozzle) has been used as the basic configuration for this work. The study is primarily based on the results of numerical simulations wherein the internal geometry variation is accomplished by changing the inlet aspect ratio (AR,) and the length of the converging section, expressed as a ratio with respect to the length of the nozzle (called 'converging section ratio*, CSR); all the other parameters are kept constant. The results from LDA experiments done on the AR4 nozzle are presented and used as validation data for the CPD simulations. Analyses of the numerical results help in understanding the variation of the jet spreading for different combinations of AR, and CSR. Two parameters are identified for describing the jet development: the cross-over point (XC), defined as the location downstream of the exit where the jet half-velocity-widths (B) along the major and minor axes are equal, and the difference in the half-velocity-widths at 30 nozzle equivalent diameters (Dm) from the exit (AB30), to ascertain the occurrence of axis-switching. For a given AR, XC varies linearly with CSR; the variation of XC is non-linear with AR, for a constant CSR. The A1330 variation is non-linear with both AR, and CSR; the other variable being kept constant. The data obtained from the simulations are further used to propose two parametric models which can be used to predict the occurrence of axis-switching, within the scope of this work. The parametric models are validated and future work is proposed.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The formation of volatile sulphur compounds in unclarified grape juice

The evolution of the sulphur gases OCS, CS2 and DMS was monitored during the clarification of freshly harvested juices from Müller-Turgau and Riesling. Immediately after crushing OCS and CS2 levels began to increase, substantially favoured by high temperatures. When fermentation started concentrations decreased. DMS was found only in fermenting juices

DNA-Liposome Hybrid Carriers for Triggered Cargo Release

The design of simple and versatile synthetic routes to accomplish triggered-release properties in carriers is of particular interest for drug delivery purposes. In this context, the programmability and adaptability of DNA nanoarchitectures in combination with liposomes have great potential to render biocompatible hybrid carriers for triggered cargo release. We present an approach to form a DNA mesh on large unilamellar liposomes incorporating a stimuli-responsive DNA building block. Upon incubation with a single-stranded DNA trigger sequence, a hairpin closes, and the DNA building block is allowed to self-contract. We demonstrate the actuation of this building block by single-molecule Förster resonance energy transfer (FRET), fluorescence recovery after photobleaching, and fluorescence quenching measurements. By triggering this process, we demonstrate the elevated release of the dye calcein from the DNA-liposome hybrid carriers. Interestingly, the incubation of the doxorubicin-laden active hybrid carrier with HEK293T cells suggests increased cytotoxicity relative to a control carrier without the triggered-release mechanism. In the future, the trigger could be provided by peritumoral nucleic acid sequences and lead to site-selective release of encapsulated chemotherapeutics. © 2022 American Chemical Society. All rights reserved

A New Technique for Finding Needles in Haystacks: A Geometric Approach to Distinguishing Between a New Source and Random Fluctuations

We propose a new test statistic based on a score process for determining the statistical significance of a putative signal that may be a small perturbation to a noisy experimental background. We derive the reference distribution for this score test statistic; it has an elegant geometrical interpretation as well as broad applicability. We illustrate the technique in the context of a model problem from high-energy particle physics. Monte Carlo experimental results confirm that the score test results in a significantly improved rate of signal detection.Comment: 5 pages, 4 figure

Cohesive properties of alkali halides

We calculate cohesive properties of LiF, NaF, KF, LiCl, NaCl, and KCl with ab-initio quantum chemical methods. The coupled-cluster approach is used to correct the Hartree-Fock crystal results for correlations and to systematically improve cohesive energies, lattice constants and bulk moduli. After inclusion of correlations, we recover 95-98 % of the total cohesive energies. The lattice constants deviate from experiment by at most 1.1 %, bulk moduli by at most 8 %. We also find good agreement for spectroscopic properties of the corresponding diatomic molecules.Comment: LaTeX, 10 pages, 1 figure, accepted by Phys. Rev.