2,786 research outputs found
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Sheep recognize familiar and unfamiliar human faces from two-dimensional images.
One of the most important human social skills is the ability to recognize faces. Humans recognize familiar faces easily, and can learn to identify unfamiliar faces from repeatedly presented images. Sheep are social animals that can recognize other sheep as well as familiar humans. Little is known, however, about their holistic face-processing abilities. In this study, we trained eight sheep (Ovis aries) to recognize the faces of four celebrities from photographic portraits displayed on computer screens. After training, the sheep chose the 'learned-familiar' faces rather than the unfamiliar faces significantly above chance. We then tested whether the sheep could recognize the four celebrity faces if they were presented in different perspectives. This ability has previously been shown only in humans. Sheep successfully recognized the four celebrity faces from tilted images. Interestingly, there was a drop in performance with the tilted images (from 79.22â±â7.5% to 66.5â±â4.1%) of a magnitude similar to that seen when humans perform this task. Finally, we asked whether sheep could recognize a very familiar handler from photographs. Sheep identified the handler in 71.8â±â2.3% of the trials without pretraining. Together these data show that sheep have advanced face-recognition abilities, comparable with those of humans and non-human primates
Micromagnetometry of two-dimensional ferromagnets
The study of atomically thin ferromagnetic crystals has led to the discovery
of unusual magnetic behaviour and provided insight into the magnetic properties
of bulk materials. However, the experimental techniques that have been used to
explore ferromagnetism in such materials cannot probe the magnetic field
directly. Here, we show that ballistic Hall micromagnetometry can be used to
measure the magnetization of individual two-dimensional ferromagnets. Our
devices are made by van der Waals assembly in such a way that the investigated
ferromagnetic crystal is placed on top of a multi-terminal Hall bar made from
encapsulated graphene. We use the micromagnetometry technique to study
atomically thin chromium tribromide (CrBr3). We find that the material remains
ferromagnetic down to monolayer thickness and exhibits strong out-of-plane
anisotropy. We also find that the magnetic response of CrBr3 varies little with
the number of layers and its temperature dependence cannot be described by the
simple Ising model of two-dimensional ferromagnetism.Comment: 19 pages, 12 figure
TCF1(+) hepatitis C virus-specific CD8(+) T cells are maintained after cessation of chronic antigen stimulation.
Differentiation and fate of virus-specific CD8(+) T cells after cessation of chronic antigen stimulation is unclear. Here we show that a TCF1(+)CD127(+)PD1(+) hepatitis C virus (HCV)-specific CD8(+) T-cell subset exists in chronically infected patients with phenotypic features of T-cell exhaustion and memory, both before and after treatment with direct acting antiviral (DAA) agents. This subset is maintained during, and for a long duration after, HCV elimination. After antigen re-challenge the less differentiated TCF1(+)CD127(+)PD1(+) population expands, which is accompanied by emergence of terminally exhausted TCF1-CD127-PD1(hi) HCV-specific CD8(+) T cells. These results suggest the TCF1(+)CD127(+)PD1(+) HCV-specific CD8(+) T-cell subset has memory-like characteristics, including antigen-independent survival and recall proliferation. We thus provide evidence for the establishment of memory-like virus-specific CD8(+) T cells in a clinically relevant setting of chronic viral infection and we uncover their fate after cessation of chronic antigen stimulation, implicating a potential strategy for antiviral immunotherapy
Electronic structure and possible pseudogap behavior in iron based superconductors
Starting from the simplified analytic model of electronic spectrum of iron -
pnictogen (chalcogen) high - temperature superconductors close to the Fermi
level, we discuss the influence of antiferromagneting (AFM)scattering both for
stoichiometric case and the region of possible short - range order AFM
fluctuations in doped compounds. Qualitative picture of the evolution of
electronic spectrum and Fermi surfaces (FS) for different dopings is presented,
with the aim of comparison with existing and future ARPES experiments. Both
electron and hole dopings are considered and possible pseudogap behavior
connected with partial FS "destruction" is demonstrated, explaining some recent
experiments.Comment: 5 pages, 4 figures, published versio
A Dendritic CellâSpecific Intercellular Adhesion Molecule 3âGrabbing Nonintegrin (Dc-Sign)âRelated Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection
The discovery of dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3âgrabbing nonintegrin (DC-SIGN) as a DC-specific ICAM-3 binding receptor that enhances HIV-1 infection of T cells in trans has indicated a potentially important role for adhesion molecules in AIDS pathogenesis. A related molecule called DC-SIGNR exhibits 77% amino acid sequence identity with DC-SIGN. The DC-SIGN and DC-SIGNR genes map within a 30-kb region on chromosome 19p13.2-3. Their strong homology and close physical location indicate a recent duplication of the original gene. Messenger RNA and protein expression patterns demonstrate that the DC-SIGNârelated molecule is highly expressed on liver sinusoidal cells and in the lymph node but not on DCs, in contrast to DC-SIGN. Therefore, we suggest that a more appropriate name for the DC-SIGNârelated molecule is L-SIGN, liver/lymph nodeâspecific ICAM-3âgrabbing nonintegrin. We show that in the liver, L-SIGN is expressed by sinusoidal endothelial cells. Functional studies indicate that L-SIGN behaves similarly to DC-SIGN in that it has a high affinity for ICAM-3, captures HIV-1 through gp120 binding, and enhances HIV-1 infection of T cells in trans. We propose that L-SIGN may play an important role in the interaction between liver sinusoidal endothelium and trafficking lymphocytes, as well as function in the pathogenesis of HIV-1
Voice-selective prediction alterations in nonclinical voice hearers
Auditory verbal hallucinations (AVH) are a cardinal symptom of psychosis but also occur in 6-13% of the general population. Voice perception is thought to engage an internal forward model that generates predictions, preparing the auditory cortex for upcoming sensory feedback. Impaired processing of sensory feedback in vocalization seems to underlie the experience of AVH in psychosis, but whether this is the case in nonclinical voice hearers remains unclear. The current study used electroencephalography (EEG) to investigate whether and how hallucination predisposition (HP) modulates the internal forward model in response to self-initiated tones and self-voices. Participants varying in HP (based on the Launay-Slade Hallucination Scale) listened to self-generated and externally generated tones or self-voices. HP did not affect responses to self vs. externally generated tones. However, HP altered the processing of the self-generated voice: increased HP was associated with increased pre-stimulus alpha power and increased N1 response to the self-generated voice. HP did not affect the P2 response to voices. These findings confirm that both prediction and comparison of predicted and perceived feedback to a self-generated voice are altered in individuals with AVH predisposition. Specific alterations in the processing of self-generated vocalizations may establish a core feature of the psychosis continuum.The Authors gratefully acknowledge all the participants who collaborated in the study, and particularly Dr. Franziska Knolle for feedback on stimulus generation, Carla Barros for help with scripts for EEG time-frequency analysis, and Dr. Celia Moreira for her advice on mixed linear models. This work was supported by the Portuguese Science National Foundation (FCT; grant numbers PTDC/PSI-PCL/116626/2010, IF/00334/2012, PTDC/MHCPCN/0101/2014) awarded to APP
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Excitations in the field-induced quantum spin liquid state of α-RuCl3
The celebrated Kitaev quantum spin liquid (QSL) is the paradigmatic example of a topological magnet with emergent excitations in the form of Majorana Fermions and gauge fluxes. Upon breaking of time-reversal symmetry, for example in an external magnetic field, these fractionalized quasiparticles acquire non-Abelian exchange statistics, an important ingredient for topologically protected quantum computing. Consequently, there has been enormous interest in exploring possible material realizations of Kitaev physics and several candidate materials have been put forward, recently including α-RuCl3. In the absence of a magnetic field this material orders at a finite temperature and exhibits low-energy spin wave excitations. However, at moderate energies, the spectrum is unconventional and the response shows evidence for fractional excitations. Here we use time-of-flight inelastic neutron scattering to show that the application of a sufficiently large magnetic field in the honeycomb plane suppresses the magnetic order and the spin waves, leaving a gapped continuum spectrum of magnetic excitations. Our comparisons of the scattering to the available calculations for a Kitaev QSL show that they are consistent with the magnetic field induced QSL phase.The work at ORNLâs Spallation Neutron Source and the High Flux Isotope Reactor was supported by the United States Department of Energy (US-DOE), Office of Science - Basic Energy Sciences (BES), Scientific User Facilities Division. Part of the research was supported by the US-DOE, Office of Science - BES, Materials Sciences and Engineering Division (P.K., C.A.B. and J-Q.Y.). D.M. and P.K. acknowledge support from the Gordon and Betty Moore Foundationâs EPiQS Initiative through Grant GBMF4416. The work at Dresden was in part supported by DFG grant SFB 1143 (J.K. and R.M.). J.K. is supported by the Marie Curie Programme under EC Grant agreements No.703697
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