15,306 research outputs found
A Conversation Among Deans on Results: Legal Education, Institutional Change, and a Decade of Gender Studies
On March 10, 2006, the Harvard Journal of Law & Gender, cosponsoring with the Harvard Civil Rights-Civil Liberties Law Review and the Harvard Law Review, hosted a conference, Results: Legal Education, Institutional Change, and a Decade of Gender Studies, to address the number of student experience studies that detail women\u27s lower performance in and dissatisfaction with law school. Rather than advocate for a particular set of responses to the different experiences of men and women in legal education, this conference sought to foster a discussion about the institutional challenges these patterns highlight. As one means of accomplishing this end, law school deans from across the country spoke about their strategies to change legal education. Edward Rubin, dean of Vanderbilt Law School, discussed how law school still acts as a rite of passage that is more suited to an era when the public sphere was male-dominated, and suggested reforms in legal curriculum in light of changes in the legal profession. W. H. Knight, dean of the University of Washington School of Law, concentrated on how law school culture might change as to become more rewarding for students and more inclusive of students from diverse backgrounds. Katherine Bartlett, dean of Duke Law School, spoke about the role of technology in infusing the context in which law operates in the study of law, as well as the Duke Blueprint, a mission statement that helps students (and faculty) examine the motives and values they will bring to becoming a lawyer
Magneto-elastic coupling and competing entropy changes in substituted CoMnSi metamagnets
We use neutron diffraction, magnetometry and low temperature heat capacity to
probe giant magneto-elastic coupling in CoMnSi-based antiferromagnets and to
establish the origin of the entropy change that occurs at the metamagnetic
transition in such compounds. We find a large difference between the electronic
density of states of the antiferromagnetic and high magnetisation states. The
magnetic field-induced entropy change is composed of this contribution and a
significant counteracting lattice component, deduced from the presence of
negative magnetostriction. In calculating the electronic entropy change, we
note the importance of using an accurate model of the electronic density of
states, which here varies rapidly close to the Fermi energy.Comment: 11 pages, 9 figures. Figures 4 and 6 were updated in v2 of this
preprint. In v3, figures 1 and 2 have been updated, while Table II and the
abstract have been extended. In v4, Table I has updated with relevant neutron
diffraction dat
Collaborative Epistemic Discourse in Classroom Information Seeking Tasks
We discuss the relationship between information seeking, and epistemic beliefs – beliefs about the source, structure, complexity, and stability of knowledge – in the context of collaborative information seeking discourses. We further suggest that both information seeking, and epistemic cognition research agendas have suffered from a lack of attention to how information seeking as a collaborative activity is mediated by talk between partners – an area we seek to address in this paper. A small-scale observational study using sociocultural discourse analysis was conducted with eight eleven year old pupils who carried out search engine tasks in small groups. Qualitative and quantitative analysis were performed on their discussions using sociocultural discourse analytic techniques. Extracts of the dialogue are reported, informed by concordance analysis and quantitative coding of dialogue duration. We find that 1) discourse which could be characterised as ‘epistemic’ is identifiable in student talk, 2) that it is possible to identify talk which is more or less productive, and 3) that epistemic talk is associated with positive learning outcomes
Thermal convection in fluidized granular systems
Thermal convection is observed in molecular dynamic simulation of a fluidized
granular system of nearly elastic hard disks moving under gravity, inside a
rectangular box. Boundaries introduce no shearing or time dependence, but the
energy injection comes from a slip (shear-free) thermalizing base. The top wall
is perfectly elastic and lateral boundaries are either elastic or periodic. The
observed convection comes from the effect of gravity and the spontaneous
granular temperature gradient that the system dynamically develops.Comment: 4 pages, 5 figure
Transient Analysis of X-34 Pressurization System
Two transient operational modes of the X-34 pressurization system were analyzed using the ROCket Engine Transition Simulation (ROCETS) program. The first operational mode considers the normal operation. For the engine burn period, the required helium mass and pressure of each propellant tank were calculated. In the second case, the possibility of failure of the pressurization system solenoid valves, its consequence on the over-pressurization, and simultaneous operation of pressurization and vent/relief systems were evaluated
Foothill: A Quasiconvex Regularization for Edge Computing of Deep Neural Networks
Deep neural networks (DNNs) have demonstrated success for many supervised
learning tasks, ranging from voice recognition, object detection, to image
classification. However, their increasing complexity might yield poor
generalization error that make them hard to be deployed on edge devices.
Quantization is an effective approach to compress DNNs in order to meet these
constraints. Using a quasiconvex base function in order to construct a binary
quantizer helps training binary neural networks (BNNs) and adding noise to the
input data or using a concrete regularization function helps to improve
generalization error. Here we introduce foothill function, an infinitely
differentiable quasiconvex function. This regularizer is flexible enough to
deform towards and penalties. Foothill can be used as a binary
quantizer, as a regularizer, or as a loss. In particular, we show this
regularizer reduces the accuracy gap between BNNs and their full-precision
counterpart for image classification on ImageNet.Comment: Accepted in 16th International Conference of Image Analysis and
Recognition (ICIAR 2019
Impacts of Grazing on Watersheds: A State of Knowledge.
36 pgLivestock grazing affects watershed hydrologic properties by removing
protective plant cover and by trampling. Reductions in the
vegetation cover may: (a) increase the impact of raindrops, (b) decrease
soil organic matter and soil aggregates, (c) increase surface
crusts, (d) decrease infiltration rates, and/or increase erosion. Resultant
impacts may include increased overland flow, reduced soil water
content, and increased erosion. Bacteria and/or nutrients as potential
pollutants from livestock grazing do not appear to be a problem on
areas not included on riparian zones.
Existing studies show no hydrologic advantage to grazing a watershed
lightly rather than moderately. Some studies show no difference
in soil loss, infiltration capacity, or soil bulk density between light.
moderate, or ungrazed pastures. Little information supports claims for
specialized grazing systems. To evaluate hydrologic impacts adequately,
additional studies, both intensive and extensive, should be
conducted
Locating the source of projectile fluid droplets
The ill-posed projectile problem of finding the source height from spattered
droplets of viscous fluid is a longstanding obstacle to accident reconstruction
and crime scene analysis. It is widely known how to infer the impact angle of
droplets on a surface from the elongation of their impact profiles. However,
the lack of velocity information makes finding the height of the origin from
the impact position and angle of individual drops not possible. From aggregate
statistics of the spatter and basic equations of projectile motion, we
introduce a reciprocal correlation plot that is effective when the polar launch
angle is concentrated in a narrow range. The vertical coordinate depends on the
orientation of the spattered surface, and equals the tangent of the impact
angle for a level surface. When the horizontal plot coordinate is twice the
reciprocal of the impact distance, we can infer the source height as the slope
of the data points in the reciprocal correlation plot. If the distribution of
launch angles is not narrow, failure of the method is evident in the lack of
linear correlation. We perform a number of experimental trials, as well as
numerical calculations and show that the height estimate is insensitive to
aerodynamic drag. Besides its possible relevance for crime investigation,
reciprocal-plot analysis of spatter may find application to volcanism and other
topics and is most immediately applicable for undergraduate science and
engineering students in the context of crime-scene analysis.Comment: To appear in the American Journal of Physics (ms 23338). Improved
readability and organization in this versio
The role of micrornas in the development of hospital acquired infection in polytrauma patients
Introduction
Traumatic injury is associated with immunosuppression and an increased risk of developing nosocomial infections. However, the immune regulatory mechanisms involved remain unclear.
Objectives
1) To describe genome-wide alterations in micro RNA (miRNA) expression following severe trauma.
2) To explore the potential role of miRNAs in mediating the post-traumatic immunosuppressive phenotype and their potential role in enhancing the risk of nosocomial infections.
Methods
Patients requiring ICU care following traumatic injury were recruited. Whole blood was collected within 2 hours of injury and 24 hours later. Total RNA (containing miRNAs) was isolated utilising PAX Gene and RNA extraction kits (Qiagen). miRNA-sequencing was performed with the Illumina HiSeq2500, and sequences were aligned to the human GRCh37 reference genome. Data analysis was carried out using the DESEQ2 package in R, and miRNAs were considered significantly altered with an adjusted p value of < 0.05. Functional enrichment analysis was performed using Ingenuity Pathway Analysis (IPA) on all miRNAs reaching an adjusted p value of < 0.1. mRNA targets of interest were identified using miRBase and TargetScan (http://www.mirbase.org, http://www.targetscan.org).
Results
49 patients were recruited and 25 patients developed nosocomial infections. Expression of 139 miRNAs was significantly altered between 2 hours and 24 hours following injury, with miR-146b, a key inhibitor of pro-inflammatory pathways[1], upregulated to the greatest degree. Figure 1 presents miRNAs that differ between those patients who developed nosocomial infections and those who did not. miR-144-5p was significantly different between the two groups at both time points. a large percentage of mRNA targets for miR-144 are involved the Cell-mediated Immune Response (Figure 2), including the B-cell receptor complex, p38MAPK, GATA3, IgG, BCL6 and the T-cell receptor. in addition, we have previously shown that the miR-374 family of miRNAs is linked to increased IL-10 expression in trauma patients[2]. IPA highlights Cancer, Haematological Disease, Immunological and Inflammatory Disease and Organismal Injury and Abnormalities as important pathways altered between infected and non-infected patients.
Conclusions
These data provide a miRNA signature of severely injured trauma patients who develop hospital acquired infection compared to those who do not, and identify the miR-144 and miR-374b families as being of particular interest for future studies of trauma-induced immune dysfunction
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