Optoacoustic Imaging in Inflammation.

Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of "light in" and "sound out" offers unprecedented scalability with a high penetration depth and resolution. The wide range of biomedical applications makes this technology a versatile tool for preclinical and clinical research. Particularly when imaging inflammation, the technology offers advantages over current clinical methods to diagnose, stage, and monitor physiological and pathophysiological processes. This review discusses the clinical perspective of using OAI in the context of imaging inflammation as well as in current and emerging translational applications

Filamentary structure in chemical tracer distributions near the subtropical jet following a wave breaking event

This paper presents a set of observations and analyses of trace gas cross sections in the extratropical upper troposphere/lower stratosphere (UTLS). The spatially highly resolved (&approx;0.5 km vertically and 12.5 km horizontally) cross sections of ozone (O₃), nitric acid (HNO₃), and peroxyacetyl nitrate (PAN), retrieved from the measurements of the CRISTA-NF infrared limb sounder flown on the Russian M55-Geophysica, revealed intricate layer structures in the region of the subtropical tropopause break. The chemical structure in this region shows an intertwined stratosphere and troposphere. The observed filaments in all discussed trace gases are of a spatial scale of less than 0.8 km vertically and about 200 km horizontally across the jet stream. Backward trajectory calculations confirm that the observed filaments are the result of a breaking Rossby wave in the preceding days. An analysis of the trace gas relationships between PAN and O₃ identifies four distinct groups of air mass: polluted subtropical tropospheric air, clean tropical upper-tropospheric air, the lowermost stratospheric air, and air from the deep stratosphere. The tracer relationships further allow the identification of tropospheric, stratospheric, and the transitional air mass made of a mixture of UT and LS air. Mapping of these air mass types onto the geo-spatial location in the cross sections reveals a highly structured extratropical transition layer (ExTL). Finally, the ratio between the measured reactive nitrogen species (HNO₃ + PAN + ClONO₂) and O₃ is analysed to estimate the influence of tropospheric pollution on the extratropical UTLS. <br><br> In combination, these diagnostics provide the first example of a multi-species two-dimensional picture of the inhomogeneous distribution of chemical species within the UTLS region. Since Rossby wave breaking occurs frequently in the region of the tropopause break, these observed fine-scale filaments are likely ubiquitous in the region. The implications of the layered structure for chemistry and radiation need to be examined, and the representation of this structure in chemistry-climate models is discussed

A review of the scientific results from the CRISTA missions

The CRyogenic Infrared Spectrometers and Telescopes for the Atmosphere (CRISTA) experiment measured atmospheric limb infrared emissions in the altitude regime from the upper troposphere to the lower thermosphere during two Shuttle missions in November 1994 and August 1997. From the recorded spectra trace gas densities and temperature fields were derived on a very dense spatial grid. In the mesosphere and lower thermosphere trace gas and temperature retrievals were carried out with the help of a state of the art non-LTE (non-local thermodynamic equilibrium) model coupled to a line-by-line radiative transfer code. The upper atmosphere data include densities of carbon dioxide, ozone, atomic oxygen, and temperature. All parameters were derived for day and night with the exception of CO2 which is available for daytime only. Additional trace gases in the mesosphere include water vapor, methane, and carbon monoxide. The main findings are a substantial depletion of CO2 between 80 and 100 km, high ozone concentrations in the secondary maximum (upper mesosphere) during night, a tertiary ozone maximum near the winter polar terminator in the middle mesosphere and well developed dynamically induced structures in latitude as well as in longitude. Such structures are also observed in the lower thermosphere where the distribution of atomic oxygen was measured up to about 180 km altitude. The atomic oxygen concentrations encountered in the thermosphere during solar minimum are much lower than predicted by MSIS. (C) 2004 COSPAR. Published by Elsevier Ltd. All rights reserved

Ultrasound in Pediatric Inflammatory Bowel Disease—A Review of the State of the Art and Future Perspectives

Inflammatory bowel disease (IBD) comprises a group of relapsing, chronic diseases of the gastrointestinal tract that, in addition to adults, can affect children and adolescents. To detect relapses of inflammation, these patients require close observation, frequent follow-up, and therapeutic adjustments. While reference standard diagnostics include anamnestic factors, laboratory and stool sample assessment, performing specific imaging in children and adolescents is much more challenging than in adults. Endoscopic and classic cross-sectional imaging modalities may be invasive and often require sedation for younger patients. For this reason, intestinal ultrasound (IUS) is becoming increasingly important for the non-invasive assessment of the intestine and its inflammatory affection. In this review, we would like to shed light on the current state of the art and provide an outlook on developments in this field that could potentially spare these patients more invasive follow-up procedures