113 research outputs found
Demonstration of an off-axis parabolic receiver for near-range retrieval of lidar ozone profiles
During the 2017 Ozone Water Land Environmental Transition Study (OWLETS), the
Langley mobile ozone lidar system utilized a new small diameter receiver to
improve the retrieval of near-surface signals from 0.1 to 1 km in altitude.
This new receiver utilizes a single 90 ∘ fiber-coupled, off-axis
parabolic mirror resulting in a compact form that is easy to align. The
single reflective surface offers the opportunity to easily expand its use to
multiple wavelengths for additional measurement channels such as visible
wavelength aerosol measurements. Detailed results compare the performance of
the receiver to both ozonesonde and in situ measurements from a UAV platform,
validating the performance of the near-surface ozone retrievals. Absolute
O3 differences averaged 7 % between lidar and ozonesonde data
from 0.1 to 1.0 km and yielded a 2.3 % high bias in the lidar data, well
within the uncertainty of the sonde measurements. Conversely, lidar
O3 measurements from 0.1 to 0.2 km averaged 10.5 % lower than
coincident UAV O3. A more detailed study under more stable
atmospheric conditions would be necessary to resolve the residual instrument
differences reported in this work. Nevertheless, this unique added capability
is a significant improvement allowing for near-surface observation of ozone.</p
Taehwa Research Forest: a receptor site for severe domestic pollution events in Korea during 2016
During the May–June 2016 International
Cooperative Air Quality Field Study in Korea (KORUS-AQ), light synoptic
meteorological forcing facilitated Seoul metropolitan pollution outflow to
reach the remote Taehwa Research Forest (TRF) site and cause regulatory
exceedances of ozone on 24Â days. Two of these severe pollution events are
thoroughly examined. The first, occurring on 17 May 2016, tracks
transboundary pollution transport exiting eastern China and the Yellow Sea,
traversing the Seoul Metropolitan Area (SMA), and then reaching TRF in the
afternoon hours with severely polluted conditions. This case study indicates
that although outflow from China and the Yellow Sea were elevated with
respect to chemically unperturbed conditions, the regulatory exceedance at
TRF was directly linked in time, space, and altitude to urban Seoul
emissions. The second case studied, which occurred on 9 June 2016, reveals that
increased levels of biogenic emissions, in combination with amplified urban
emissions, were associated with severe levels of pollution and a regulatory
exceedance at TRF. In summary, domestic emissions may be causing more
pollution than by transboundary pathways, which have been historically
believed to be the major source of air pollution in South Korea. The case
studies are assessed with multiple aircraft, model (photochemical and
meteorological) simulations, in situ chemical sampling, and extensive
ground-based profiling at TRF. These observations clearly identify TRF and
the surrounding rural communities as receptor sites for severe pollution
events associated with Seoul outflow, which will result in long-term
negative effects to both human health and agriculture in the affected areas.</p
Attention-dependent modulation of cortical taste circuits revealed by granger causality with signal-dependent noise
We show, for the first time, that in cortical areas, for example the insular, orbitofrontal, and lateral prefrontal cortex, there is signal-dependent noise in the fMRI blood-oxygen level dependent (BOLD) time series, with the variance of the noise increasing approximately linearly with the square of the signal. Classical Granger causal models are based on autoregressive models with time invariant covariance structure, and thus do not take this signal-dependent noise into account. To address this limitation, here we describe a Granger causal model with signal-dependent noise, and a novel, likelihood ratio test for causal inferences. We apply this approach to the data from an fMRI study to investigate the source of the top-down attentional control of taste intensity and taste pleasantness processing. The Granger causality with signal-dependent noise analysis reveals effects not identified by classical Granger causal analysis. In particular, there is a top-down effect from the posterior lateral prefrontal cortex to the insular taste cortex during attention to intensity but not to pleasantness, and there is a top-down effect from the anterior and posterior lateral prefrontal cortex to the orbitofrontal cortex during attention to pleasantness but not to intensity. In addition, there is stronger forward effective connectivity from the insular taste cortex to the orbitofrontal cortex during attention to pleasantness than during attention to intensity. These findings indicate the importance of explicitly modeling signal-dependent noise in functional neuroimaging, and reveal some of the processes involved in a biased activation theory of selective attention
Periodontal conditions, oral Candida albicans and salivary proteins in type 2 diabetic subjects with emphasis on gender
<p>Abstract</p> <p>Background</p> <p>The association between periodontal conditions, oral yeast colonisation and salivary proteins in subjects with type 2 diabetes (T2D) is not yet documented. The present study aimed to assess the relationship between these variables in type 2 diabetic subjects with reference to gender.</p> <p>Methods</p> <p>Fifty-eight type 2 diabetic subjects (23 males and 35 females) with random blood glucose level ≥ 11.1 mmol/L were investigated. Periodontal conditions (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PD] (4 to 6 mm and ≥ 6 mm), oral yeasts, salivary immunoglobulin (Ig) A, IgG and total protein concentrations, and number of present teeth were determined.</p> <p>Results</p> <p>Periodontal conditions (PI [<it>p </it>< 0.00001], BOP [<it>p </it>< 0.01] and PD of 4 to 6 mm [<it>p </it>< 0.001], salivary IgG (μg)/mg protein (<it>p </it>< 0.001) and salivary total protein concentrations (<it>p </it>< 0.05) were higher in type 2 diabetic females with <it>Candida albicans </it>(<it>C. albicans</it>) colonisation compared to males in the same group. Type 2 diabetic females with <it>C. albicans </it>colonisation had more teeth compared to males in the same group (<it>p </it>< 0.0001).</p> <p>Conclusion</p> <p>Clinical and salivary parameters of periodontal inflammation (BOP and IgG (μg)/mg protein) were higher in type 2 diabetic females with oral <it>C. albicans </it>colonisation compared to males in the same group. Further studies are warranted to evaluate the association of gender with these variables in subjects with T2D.</p
Genetically Encoded Photo-cross-linkers Map the Binding Site of an Allosteric Drug on a G Protein-Coupled Receptor
Short-Lived Trace Gases in the Surface Ocean and the Atmosphere
The two-way exchange of trace gases between the ocean and the atmosphere is important for both the chemistry and physics of the atmosphere and the biogeochemistry of the oceans, including the global cycling of elements. Here we review these exchanges and their importance for a range of gases whose lifetimes are generally short compared to the main greenhouse gases and which are, in most cases, more reactive than them. Gases considered include sulphur and related compounds, organohalogens, non-methane hydrocarbons, ozone, ammonia and related compounds, hydrogen and carbon monoxide. Finally, we stress the interactivity of the system, the importance of process understanding for modeling, the need for more extensive field measurements and their better seasonal coverage, the importance of inter-calibration exercises and finally the need to show the importance of air-sea exchanges for global cycling and how the field fits into the broader context of Earth System Science
Structural Determinants of the Supramolecular Organization of G Protein-Coupled Receptors in Bilayers
Everything under control? Comparing Knepp Estate rewilding project with ‘traditional’ nature conservation
‘Rewilding’ is an increasingly prominent concept in conservation, but one that has attracted controversy. Debate frequently focuses on human ‘control’ over nature. ‘Traditional’ conservation has been presented as involving ‘high control,’ and rewilding as ‘low control.’ Opposition to rewilding often stems from a perceived lack of control and associated perception of increased risk and uncertainty. This paper explores the concept of control in conservation. I identify multiple dimensions of control (‘stabilisation’, ‘location’, ‘prediction’ and ‘outputs’), illustrating that control is not a simple, linear concept. I compare two ethnographic case studies: the Sussex Wildlife Trust’s Old Lodge nature reserve; and Knepp Estate, one of the most influential rewilding projects in the UK. I use them to test assertions made about control in ‘traditional’ conservation and ‘rewilding’. I outline how Old Lodge does not exert precise control in all respects, but involves elements of uncertainty and negotiation. I describe how Knepp’s model of rewilding reduces control in some dimensions but potentially increases it in others. I conclude that, while Knepp’s rewilding does represent a significant conceptual departure from ‘traditional’ conservation, it should not be characterised as an approach that reduces control in a simplistic way. Based on this analysis, I argue that reduction of control does not necessarily underpin the concept of rewilding. Rather, there is interplay between different control dimensions that combine to form multiple ‘configurations of control.’ Using a framework of ‘configurations of control’, debate about the place of rewilding in conservation can become less polarised, and instead involve an active discussion of what configuration of control is desired. This analysis has the potential to increase understanding of rewilding projects as part of plural conservation strategies, in the UK and globally
pH-responsive protein microcapsules fabricated via glutaraldehyde mediated covalent layer-by-layer assembly
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