Precautions with Snakes.

2 p

Poisonous Snakes of Texas.

12 p

Connection and disconnection as predictors of mental health and wellbeing

Despite the established literature on connection to others, and burgeoning research on self-connection, researchers have paid little attention to the equivalent experiences of disconnection that people can experience in their everyday lives. The current research examined connection and disconnection from oneself and others. Specifically, across two studies, participants listed up to twenty words or phrases that they experienced related to each form of (dis)connection. Study 1 focused on how these affected participants’ mental health (i.e. anxiety and depression), while study 2 examined positive forms of wellbeing (i.e., flourishing and life satisfaction). Results suggested that increased mental health was most strongly related to a greater experience of connection to others. Flourishing also increased as one’s experience of other-connection increased. By contrast, poorer wellbeing was related to a greater experience of disconnection from others. Finally, life satisfaction decreased when participants experienced greater self-disconnection. In all, these findings provide an initial test of and support for the continued examination of various forms of both connection and disconnection

Poisonous Snakes in Texas.

6 p

Timing in internationalisation: Automobile component suppliers entering emerging markets.

This research focuses on researching the variables that impact on time in internationalisation processes within the automotive supply industry, and thus for companies further down the supply chain. This is regarded as important, since time is a critical success factor when doing international business in that specific industry (keeping milestones, being ready on time for new vehicle launches in a small window of opportunity etc.). The theories around internationalisation are out-dated, while the global environment is changing ever more rapidly. This supports the idea that a gap in knowledge exists, and explains the wish of the researcher to take a fresh look at internationalisation, specifically at the timing aspects involved. Following an interpretive inductive analytical approach from a neo-empiricist standpoint, the researcher conducted 12 interviews with 5 companies within the industry. The companies comprised all the companies in that sector of industry, listed by the Federal Reserve Bank of North Germany. The outcome of the triangulated data collection and thematic analysis is the BIDS-L-Model (Brand, Information, Direct, Speed, Learning), symbolizing the variables that influence time in the internationalisation process, in chronological order. This model not only fills the gap in knowledge but also, when applied in practice, it will fundamentally change the way suppliers further down the supply chain architecture their internationalisation process, thus leading to massive improvements. The next step is to apply the model using 4 pillars. Firstly, the researcher will teach the model in his role as associate university lecturer. Secondly, he will publish it, e.g. in the Newsletter of the German Association of Automotive Industry, which reaches 600 member companies; and thirdly, he will offer consultancy to small and medium enterprises to help them to achieve successful timing of their internationalisation process. Finally, the researcher will apply the model in his leading Marketing role for Asia in the strategy planning process

The anti-CD30 monoclonal antibody SGN-30 promotes growth arrest and DNA fragmentation in vitro and affects antitumor activity in models of Hodgkin’s disease. Cancer Res

ABSTRAC

Engineering cooperative tecto–RNA complexes having programmable stoichiometries

High affinity and specificity RNA–RNA binding interfaces can be constructed by combining pairs of GNRA loop/loop–receptor interaction motifs. These interactions can be fused using flexible four-way junction motifs to create divalent, self-assembling scaffolding units (‘tecto-RNA’) that have favorable properties for nanomedicine and other applications. We describe the design and directed assembly of tecto-RNA units ranging from closed, cooperatively assembling ring-shaped complexes of programmable stoichiometries (dimers, trimers and tetramers) to open multimeric structures. The novelty of this work is that tuning of the stoichiometries of self-assembled complexes is achieved by precise positioning of the interaction motifs in the monomer units rather than changing their binding specificities. Structure-probing and transmission electron microscopy studies as well as thermodynamic analysis support formation of closed cooperative complexes that are highly resistant to nuclease digestion. The present designs provide two helical arms per RNA monomer for further functionalization aims