492 research outputs found
A Chandra X-ray detection of the L dwarf binary Kelu-1: Simultaneous Chandra and Very Large Array observations
Magnetic activity in ultracool dwarfs, as measured in X-rays and H,
shows a steep decline after spectral type M7-M8. So far, no L dwarf has been
detected in X-rays. In contrast, L dwarfs may have higher radio activity than M
dwarfs. We observe L and T dwarfs simultaneously in X-rays and radio to
determine their level of magnetic activity in the context of the general
decline of magnetic activity with cooler effective temperatures. The field L
dwarf binary Kelu-1 was observed simultaneously with Chandra and the Very Large
Array. Kelu-1AB was detected in X-rays with erg/s, while it remained undetected in the radio down to a limit of erg/s/Hz. We argue that,
whereas the X-ray and H emissions decline in ultracool dwarfs with
decreasing effective temperature, the radio luminosity stays (more or less)
constant across M and early-L dwarfs. The radio surface flux or the luminosity
may better trace magnetic activity in ultracool dwarfs than the ratio of the
luminosity to the bolometric luminosity. Deeper radio observations (and at
short frequencies) are required to determine if and when the cut-off in radio
activity occurs in L and T dwarfs, and what kind of emission mechanism takes
place in ultracool dwarfs.Comment: Accepted for publication as a Letter in Astronomy & Astrophysic
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
The -cleus experiment: A gram-scale fiducial-volume cryogenic detector for the first detection of coherent neutrino-nucleus scattering
We discuss a small-scale experiment, called -cleus, for the first
detection of coherent neutrino-nucleus scattering by probing nuclear-recoil
energies down to the 10 eV-regime. The detector consists of low-threshold
CaWO and AlO calorimeter arrays with a total mass of about 10 g and
several cryogenic veto detectors operated at millikelvin temperatures.
Realizing a fiducial volume and a multi-element target, the detector enables
active discrimination of , neutron and surface backgrounds. A first
prototype AlO device, operated above ground in a setup without
shielding, has achieved an energy threshold of eV and further
improvements are in reach. A sensitivity study for the detection of coherent
neutrino scattering at nuclear power plants shows a unique discovery potential
(5) within a measuring time of weeks. Furthermore, a site
at a thermal research reactor and the use of a radioactive neutrino source are
investigated. With this technology, real-time monitoring of nuclear power
plants is feasible.Comment: 14 pages, 19 figure
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce conformation change, oligomerization and pore formation in mitochondria. BH3-only proteins, with the exception of Bid, are intrinsically disordered and therefore, functional studies often utilize peptides based on just their BH3 domains. However, these reagents do not possess the hydrophobic membrane targeting domains found on the native BH3-only molecule. To generate each BH3-only protein as a recombinant protein that could efficiently target mitochondria, we developed recombinant Bid chimeras in which the BH3 domain was replaced with that of other BH3-only proteins (Bim, Puma, Noxa, Bad, Bmf, Bik and Hrk). The chimeras were stable following purification, and each immunoprecipitated with full-length Bcl-xL according to the specificity reported for the related BH3 peptide. When tested for activation of Bak and Bax in mitochondrial permeabilization assays, Bid chimeras were ~1000-fold more effective than the related BH3 peptides. BH3 sequences from Bid and Bim were the strongest activators, followed by Puma, Hrk, Bmf and Bik, while Bad and Noxa were not activators. Notably, chimeras and peptides showed no apparent preference for activating Bak or Bax. In addition, within the BH3 domain, the h0 position recently found to be important for Bax activation, was important also for Bak activation. Together, our data with full-length proteins indicate that most BH3-only proteins can directly activate both Bak and Bax
Dark-Photon Search using Data from CRESST-II Phase 2
Identifying the nature and origin of dark matter is one of the major
challenges for modern astro and particle physics. Direct dark-matter searches
aim at an observation of dark-matter particles interacting within detectors.
The focus of several such searches is on interactions with nuclei as provided
e.g. by Weakly Interacting Massive Particles. However, there is a variety of
dark-matter candidates favoring interactions with electrons rather than with
nuclei. One example are dark photons, i.e., long-lived vector particles with a
kinetic mixing to standard-model photons. In this work we present constraints
on this kinetic mixing based on data from CRESST-II Phase 2 corresponding to an
exposure before cuts of 52\,kg-days. These constraints improve the existing
ones for dark-photon masses between 0.3 and 0.7\,keV/c.Comment: submitted EPJ
Results on MeV-scale dark matter from a gram-scale cryogenic calorimeter operated above ground
Models for light dark matter particles with masses below 1 GeV/c are a
natural and well-motivated alternative to so-far unobserved weakly interacting
massive particles. Gram-scale cryogenic calorimeters provide the required
detector performance to detect these particles and extend the direct dark
matter search program of CRESST. A prototype 0.5 g sapphire detector developed
for the -cleus experiment has achieved an energy threshold of
eV, which is one order of magnitude lower than previous
results and independent of the type of particle interaction. The result
presented here is obtained in a setup above ground without significant
shielding against ambient and cosmogenic radiation. Although operated in a
high-background environment, the detector probes a new range of light-mass dark
matter particles previously not accessible by direct searches. We report the
first limit on the spin-independent dark matter particle-nucleon cross section
for masses between 140 MeV/c and 500 MeV/c.Comment: 6 pages, 6 figures, v3: ancillary files added, v4: high energy
spectrum (0.6-12keV) added to ancillary file
Limits on Dark Matter Effective Field Theory Parameters with CRESST-II
CRESST is a direct dark matter search experiment, aiming for an observation
of nuclear recoils induced by the interaction of dark matter particles with
cryogenic scintillating calcium tungstate crystals. Instead of confining
ourselves to standard spin-independent and spin-dependent searches, we
re-analyze data from CRESST-II using a more general effective field theory
(EFT) framework. On many of the EFT coupling constants, improved exclusion
limits in the low-mass region (< 3-4 GeV) are presented.Comment: 7 pages, 9 figure
Exploring CEvNS with NUCLEUS at the Chooz Nuclear Power Plant
Coherent elastic neutrino-nucleus scattering (CENS) offers a unique way
to study neutrino properties and to search for new physics beyond the Standard
Model. Nuclear reactors are promising sources to explore this process at low
energies since they deliver large fluxes of (anti-)neutrinos with typical
energies of a few MeV. In this paper, a new-generation experiment to study
CENS is described. The NUCLEUS experiment will use cryogenic detectors
which feature an unprecedentedly low energy threshold and a time response fast
enough to be operated in above-ground conditions. Both sensitivity to
low-energy nuclear recoils and a high event rate tolerance are stringent
requirements to measure CENS of reactor antineutrinos. A new experimental
site, denoted the Very-Near-Site (VNS) at the Chooz nuclear power plant in
France is described. The VNS is located between the two 4.25 GW
reactor cores and matches the requirements of NUCLEUS. First results of on-site
measurements of neutron and muon backgrounds, the expected dominant background
contributions, are given. In this paper a preliminary experimental setup with
dedicated active and passive background reduction techniques is presented.
Furthermore, the feasibility to operate the NUCLEUS detectors in coincidence
with an active muon-veto at shallow overburden is studied. The paper concludes
with a sensitivity study pointing out the promising physics potential of
NUCLEUS at the Chooz nuclear power plant
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