8 research outputs found
Enhancing Entity Alignment Between Wikidata and ArtGraph using LLMs
Knowledge graphs (KGs) are used in a wide variety of applications, including within the cultural heritage
domain. An important prerequisite of such applications is the quality and completeness of the data.
Using a single KG might not be enough to fulfill this requirement. The absence of connections between
KGs complicates taking advantage of the complementary data they can provide. This paper focuses on
the Wikidata and A rtG raph KGs, which exhibit gaps in content that can be filled by enriching one
with data from the other. Entity alignment can help to combine data from KGs by connecting entities
that refer to the same real-world entities. However, entity alignment in art-domain knowledge graphs
remains under-explored. In the pursuit of entity alignment between A rtG raph and Wikidata, a hybrid
approach is proposed. The first part, which we call WES (Wikidata Entity Search), utilizes traditional
Wikidata SPARQL queries and is followed by a supplementary sequence-to-sequence large language
model (LLM) pipeline that we denote as pArtLink. The combined approach successfully aligned artworks
and artists, with WES identifying entities for 14,982 artworks and 2,029 artists, and pArtLink further
aligning 76 additional artists, thus enhancing the alignment process beyond WES’ capabilities
Real‐world complication burden and disease management paradigms in transfusion‐related β‐thalassaemia in Greece: Results from ULYSSES, an epidemiological, multicentre, retrospective cross‐sectional study
Abstract Patients with transfusion‐dependent beta (β)‐thalassaemia experience a broad range of complications. ULYSSES, an epidemiological, multicentre, retrospective cross‐sectional study, aimed to assess the prevalence and severity of treatment and disease complications, capture disease management and identify predictors of complications in patients with transfusion‐dependent β‐thalassaemia, treated in routine settings in Greece. Eligible patients were adults diagnosed with β‐thalassaemia ≥12 months before enrolment and having received ≥6 red blood cell (RBC) units (excluding elective surgery) with no transfusion‐free period ≥35 days in the 24 weeks before enrolment. Primary data were collected at a single visit and through chart review. Between Oct 21, 2019, and Jun 15, 2020, 201 eligible patients [median (interquartile range, IQR) age 45.7 (40.2–50.5) years; 75.6% > 40 years old; 64.2% female] were enrolled, a mean (standard deviation) of 42.9 (7.8) years after diagnosis. Median (IQR) age at diagnosis and RBC transfusion initiation were 0.8 (0.4–2.8) and 1.3 (1.0–5.0) years, respectively. From diagnosis to enrolment, patients had developed a median of six (range: 1–55) complications; 19.6% were grade ≥3. The most represented complications were endocrine/metabolic/nutrition disorders (91.5%), surgical/medical procedures (67.7%) and blood/lymphatic system disorders (64.7%). Real‐world data generated by ULYSSES underscore the substantial complication burden of transfusion‐dependent β‐thalassaemia patients, routinely managed in Greece
Sickle-Cell Disease in Greece: Patient Reported Outcomes Related to Clinical Complications, Treatment Choices and Attitudes, Beliefs and Trends Affecting Potential Participation in Clinical Trials - a Greek National Multicentric Study
Hepatitis C Virus Infection, but Not Hepatic Iron Overload Is the Dominant Risk Factor for the Manifestation of Hepatocellular Carcinoma Among Greek Thalassemic Patients
National registry of hemoglobinopathies in Greece: updated demographics, current trends in affected births, and causes of mortality
National registries constitute an invaluable source of information and
contribute to the improvement of hemoglobinopathy management. Herein, we
present the second updated report of the National Registry for
Haemoglobinopathies in Greece (NRHG) and critically discuss the time
trends in demographics, affected births, and causes of mortality.
Thirty-eight Greek hemoglobinopathy units reported data from diagnosis
to the last follow-up or death by retrospectively completing an
electronic form. Four thousand thirty-two patients were eligible for
inclusion; more than half of them had thalassaemia major. Compared to
the previous report, a reduction in the total number of all
hemoglobinopathies except for hemoglobinopathy was evident. The total
number of affected births was also reduced; most of them were
attributable to diagnostic errors and lack of awareness. Importantly,
data on iron overload are reported for the first time; although most
patients had low or moderate liver iron concentration (LIC) values, a
non-negligible proportion of patients had high LIC. The burden due to
heart iron overload was less prominent. Cardiac- and liver-related
complications are the major causes of morbidity and mortality. From 2000
to 2015, a decrease in heart-related deaths along with an increase in
liver-associated fatalities was observed. The Hellenic Prevention
Program along with advances in chelation regimens and iron status
monitoring have resulted in improved patient outcomes. The NRHG gives
insight into the effectiveness of prevention programs, the therapeutic
management of hemoglobinopathies and associated outcomes. NRHG may
contribute to the formulation of a roadmap for hemoglobinopathies in
Europe and promote the implementation of effective public health
policies