Consumer behaviour on the wine market in Nitra region

Today, no businesses can afford to ignore marketing, because it plays a very important role in every company. Last years entrepreneurs have started to feel the need of promotion their products and activities. Competition is high not just from abroad, but also in our country. In wine field customers can choose from many products and wine producers should try hard to survive. Using marketing tools is in this field as need as in any other businesses and without them there is not a big chance to be successful. Marketing tool is a mean of communication with a customer and a customer plays the most important role. Using the right marketing tools can make your brand special – different from the others. Doing marketing research helps companies to know their target group - customers that really buy or want to buy their products. Asking the right question in marketing research can help them to use the right marketing tools. In many cases it means to spend marketing budget the way that will truly communicate with their target group. Then there is just a short way to be successful – in our case in wine field

Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines

Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much