Experimental evidence of two-band behavior of MgB2

The break-junction tunneling has been systematically investigated in MgB2. Two types of the break-junction contacts have been exploited on the same samples, which demonstrated tunnel contact like (SIS) and point contact like (SnS) behavior. Both of them have shown the existence of the two distinct energy gaps. We have observed also the peculiarities on the I(V)- characteristics related to Leggett's collective mode assisted tunneling. --> Corresponding author address: [email protected]: 14 pages, 6 figures, 1 table; corrected typos and fig

GASP XXVI. HI gas in jellyfish galaxies : the case of JO201 and JO206

Please read abstract in the article.European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme grant agreement no. 679627 and no.833824, project name FORNAX and GASP, respectively. We acknowledge funding from the agreement ASI-INAF n.2017-14-H.0, as well as from the INAF main-stream funding programme. M. R’s research is supported by the SARAO HCD programme via the "New Scientific Frontiers with Precision Radio Interferometry" research group grant. M. R. acknowledges support from the Italian Ministry of Foreign A airs and International Cooperation (MAECI Grant Number ZA18GR02) and the South African Department of Science and Technology’s National Research Foundation (DST-NRF Grant Number 113121) as part of the ISARP RADIOSKY2020 Joint Research Scheme. B. V. and M. G. also acknowledge the Italian PRIN-Miur 2017 (PI A. Cimatti). Y. J. acknowledges financial support from CONICYT PAI (Concurso Nacional de Insercion en la Academia 2017), No. 79170132 and FONDECYT Iniciación 2018 No. 11180558. M. V. acknowledges support by the Netherlands Foundation for Scientific Research (NWO) through VICI grant 016.130.338.http://www.aanda.orgam2020Physic

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

SummaryPGC-1α is a transcriptional coactivator induced by exercise that gives muscle many of the best known adaptations to endurance-type exercise but has no effects on muscle strength or hypertrophy. We have identified a form of PGC-1α (PGC-1α4) that results from alternative promoter usage and splicing of the primary transcript. PGC-1α4 is highly expressed in exercised muscle but does not regulate most known PGC-1α targets such as the mitochondrial OXPHOS genes. Rather, it specifically induces IGF1 and represses myostatin, and expression of PGC-1α4 in vitro and in vivo induces robust skeletal muscle hypertrophy. Importantly, mice with skeletal muscle-specific transgenic expression of PGC-1α4 show increased muscle mass and strength and dramatic resistance to the muscle wasting of cancer cachexia. Expression of PGC-1α4 is preferentially induced in mouse and human muscle during resistance exercise. These studies identify a PGC-1α protein that regulates and coordinates factors involved in skeletal muscle hypertrophy

Incidence and Management of Neonatal Pneumothorax in a 10-Hospital Regional Perinatal Network in Switzerland: A Retrospective Observational Study.

Pneumothorax (PTX) is a potentially life-threatening condition that affects neonates, with an incidence of 0.05 to 2%. Its management includes conservative treatment, chest tube (CT) drainage, and needle aspiration (NA). Aims were to evaluate the incidence of PTX in a 10-hospital perinatal network, its clinical characteristics and risk factors, and to compare the different treatment options. All neonates diagnosed with PTX and hospitalized in the network were included in this retrospective observational trial over a period of 30 months. Primary outcome was the incidence of PTX. Secondary outcomes were the treatment modality, the length of stay (LOS), and the number of chest X-rays. Among the 173 neonates included, the overall incidence of PTX was 0.56 per 100 births with a large range among the hospitals (0.12-1.24). Thirty-nine percent of pneumothoraces were treated conservatively, 41% by CT drainage, 13% by NA, and 7% by combined treatment. Failure rate was higher for NA (37%) than for CT drainage (9%). However, the number of X-rays was lower for patients treated by NA, with a median of 6 (interquartile range [IQR] 4-6.25), than by CT drainage, with a median of 9 (IQR 7-12). LOS was shorter for NA than for CT drainage, with a median of 2 (IQR 1-4.25) and 6 days (IQR 3-15), respectively. Complications, including apnea and urinary retention, occurred in 28% of patients managed with CT drainage, whereas none was observed with NA. High variability of PTX incidence was observed among the hospitals within the network, but these values correspond to the literature. NA showed to reduce the number of X-rays, the LOS, and complications compared with CT drainage, but it carries a high failure rate. This study helped provide a new decisional management algorithm to harmonize and improve PTX treatment within our network. · Neonatal pneumothorax (PTX) is a frequent pathology with a high incidence requiring urgent management.. · We report a large variability of PTX incidence between different hospitals of the same network.. · Needle aspiration carries higher failure rate, shorter hospital stay duration without complications reported.