1,140 research outputs found
Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier
Although interferon-λ [also known as type III interferon or interleukin-28 (IL-28)/IL-29] restricts infection by several viruses, its inhibitory mechanism has remained uncertain. We used recombinant interferon-λ and mice lacking the interferon-λ receptor (IFNLR1) to evaluate the effect of interferon-λ on infection with West Nile virus, an encephalitic flavivirus. Cell culture studies in mouse keratinocytes and dendritic cells showed no direct antiviral effect of exogenous interferon-λ, even though expression of interferon-stimulated genes was induced. We observed no differences in West Nile virus burden between wild-type and Ifnlr1-/- mice in the draining lymph nodes, spleen, or blood. We detected increased West Nile virus infection in the brain and spinal cord of Ifnlr1-/- mice, yet this was not associated with a direct antiviral effect in mouse neurons. Instead, we observed an increase in blood-brain barrier permeability in Ifnlr1-/- mice. Treatment of mice with pegylated interferon-λ2 resulted in decreased blood-brain barrier permeability, reduced West Nile virus infection in the brain without affecting viremia, and improved survival against lethal virus challenge. An in vitro model of the blood-brain barrier showed that interferon-λ signaling in mouse brain microvascular endothelial cells increased transendothelial electrical resistance, decreased virus movement across the barrier, and modulated tight junction protein localization in a protein synthesis- and signal transducer and activator of transcription 1 (STAT1)-independent manner. Our data establish an indirect antiviral function of interferon-λ in which noncanonical signaling through IFNLR1 tightens the blood-brain barrier and restricts viral neuroinvasion and pathogenesis
Phonons and specific heat of linear dense phases of atoms physisorbed in the grooves of carbon nanotube bundles
The vibrational properties (phonons) of a one-dimensional periodic phase of
atoms physisorbed in the external groove of the carbon nanotube bundle are
studied. Analytical expressions for the phonon dispersion relations are
derived. The derived expressions are applied to Xe, Kr and Ar adsorbates. The
specific heat pertaining to dense phases of these adsorbates is calculated.Comment: 4 PS figure
Spin instabilities and quantum phase transitions in integral and fractional quantum Hall states
The inter-Landau-level spin excitations of quantum Hall states at filling
factors nu=2 and 4/3 are investigated by exact numerical diagonalization for
the situation in which the cyclotron (hbar*omega_c) and Zeeman (E_Z) splittings
are comparable. The relevant quasiparticles and their interactions are studied,
including stable spin wave and skyrmion bound states. For nu=2, a spin
instability at a finite value of epsilon=hbar*omega_c-E_Z leads to an abrupt
paramagnetic to ferromagnetic transition, in agreement with the mean-field
approximation. However, for nu=4/3 a new and unexpected quantum phase
transition is found which involves a gradual change from paramagnetic to
ferromagnetic occupancy of the partially filled Landau level as epsilon is
decreased.Comment: 4 pages, 5 figures, submitted to Phys.Rev.Let
New precise determination of the \tau lepton mass at KEDR detector
The status of the experiment on the precise lepton mass measurement
running at the VEPP-4M collider with the KEDR detector is reported. The mass
value is evaluated from the cross section behaviour around the
production threshold. The preliminary result based on 6.7 pb of data is
MeV. Using 0.8 pb of data
collected at the peak the preliminary result is also obtained:
eV.Comment: 6 pages, 8 figures; The 9th International Workshop on Tau-Lepton
Physics, Tau0
Continuous wave optical parametric oscillator for quartz-enhanced photoacoustic trace gas sensing
A continuous wave optical parametric oscillator, generating up to 300 mW idler output in the 3–4 μm wavelength region, and pumped by a fiber-amplified DBR diode laser is used for trace gas detection by means of quartz-enhanced photoacoustic spectroscopy (QEPAS). Mode-hop-free tuning of the OPO output over 5.2 cm-1 and continuous spectral coverage exceeding 16.5 cm-1 were achieved via electronic pump source tuning alone. Online monitoring of the idler wavelength, with feedback to the DBR diode laser, provided an automated closed-loop control allowing arbitrary idler wavelength selection within the pump tuning range and locking of the idler wavelength with a stability of 1.7×10-3 cm-1 over at least 30 min.\ud
\ud
Using this approach, we locked the idler wavelength at an ethane absorption peak and obtained QEPAS data to verify the linear response of the QEPAS signal at different ethane concentrations (100 ppbv-20 ppmv) and different power levels. The detection limit for ethane was determined to be 13 ppbv (20 s averaging), corresponding to a normalized noise equivalent absorption coefficient of 4.4×10-7 cm-1 W/Hz1/2
Impact of long-range interactions on the disordered vortex lattice
The interaction between the vortex lines in a type-II superconductor is
mediated by currents. In the absence of transverse screening this interaction
is long-ranged, stiffening up the vortex lattice as expressed by the dispersive
elastic moduli. The effect of disorder is strongly reduced, resulting in a
mean-squared displacement correlator =
characterized by a mere logarithmic growth with distance. Finite screening cuts
the interaction on the scale of the London penetration depth \lambda and limits
the above behavior to distances R<\lambda. Using a functional renormalization
group (RG) approach, we derive the flow equation for the disorder correlation
function and calculate the disorder-averaged mean-squared relative displacement
\propto ln^{2\sigma} (R/a_0). The logarithmic growth (2\sigma=1) in
the perturbative regime at small distances [A.I. Larkin and Yu.N. Ovchinnikov,
J. Low Temp. Phys. 34, 409 (1979)] crosses over to a sub-logarithmic growth
with 2\sigma=0.348 at large distances.Comment: 9 pages, no figure
Measurement of \Gamma_{ee}(J/\psi)*Br(J/\psi->e^+e^-) and \Gamma_{ee}(J/\psi)*Br(J/\psi->\mu^+\mu^-)
The products of the electron width of the J/\psi meson and the branching
fraction of its decays to the lepton pairs were measured using data from the
KEDR experiment at the VEPP-4M electron-positron collider. The results are
\Gamma_{ee}(J/\psi)*Br(J/\psi->e^+e^-)=(0.3323\pm0.0064\pm0.0048) keV,
\Gamma_{ee}(J/\psi)*Br(J/\psi->\mu^+\mu^-)=(0.3318\pm0.0052\pm0.0063) keV.
Their combinations
\Gamma_{ee}\times(\Gamma_{ee}+\Gamma_{\mu\mu})/\Gamma=(0.6641\pm0.0082\pm0.0100)
keV,
\Gamma_{ee}/\Gamma_{\mu\mu}=1.002\pm0.021\pm0.013 can be used to improve
theaccuracy of the leptonic and full widths and test leptonic universality.
Assuming e\mu universality and using the world average value of the lepton
branching fraction, we also determine the leptonic \Gamma_{ll}=5.59\pm0.12 keV
and total \Gamma=94.1\pm2.7 keV widths of the J/\psi meson.Comment: 7 pages, 6 figure
Search for narrow resonances in e+ e- annihilation between 1.85 and 3.1 GeV with the KEDR Detector
We report results of a search for narrow resonances in e+ e- annihilation at
center-of-mass energies between 1.85 and 3.1 GeV performed with the KEDR
detector at the VEPP-4M e+ e- collider. The upper limit on the leptonic width
of a narrow resonance Gamma(R -> ee) Br(R -> hadr) < 120 eV has been obtained
(at 90 % C.L.)
Domain regime in two-dimensional disordered vortex matter
A detailed numerical study of the real space configuration of vortices in
disordered superconductors using 2D London-Langevin model is presented. The
magnetic field is varied between 0 and for various pinning
strengths . For weak pinning, an inhomogeneous disordered vortex matter
is observed, in which the topologically ordered vortex lattice survives in
large domains. The majority of the dislocations in this state are confined to
the grain boundaries/domain walls. Such quasi-ordered configurations are
observed in the intermediate fields, and we refer it as the domain regime (DR).
The DR is distinct from the low-field and the high-fields amorphous regimes
which are characterized by a homogeneous distribution of defects over the
entire system. Analysis of the real space configuration suggests domain wall
roughening as a possible mechanism for the crossover from the DR to the
high-field amorphous regime. The DR also shows a sharp crossover to the high
temperature vortex liquid phase. The domain size distribution and the roughness
exponent of the lattice in the DR are also calculated. The results are compared
with some of the recent Bitter decoration experiments.Comment: 9 pages, 9 figure
Flux-lattice melting in two-dimensional disordered superconductors
The flux line lattice melting transition in two-dimensional pure and
disordered superconductors is studied by a Monte Carlo simulation using the
lowest Landau level approximation and quasi-periodic boundary condition on a
plane. The position of the melting line was determined from the diffraction
pattern of the superconducting order parameter. In the clean case we confirmed
the results from earlier studies which show the existence of a quasi-long range
ordered vortex lattice at low temperatures. Adding frozen disorder to the
system the melting transition line is shifted to slightly lower fields. The
correlations of the order parameter for translational long range order of the
vortex positions seem to decay slightly faster than a power law (in agreement
with the theory of Carpentier and Le Doussal) although a simple power law decay
cannot be excluded. The corresponding positional glass correlation function
decays as a power law establishing the existence of a quasi-long range ordered
positional glass formed by the vortices. The correlation function
characterizing a phase coherent vortex glass decays however exponentially
ruling out the possible existence of a phase coherent vortex glass phase.Comment: 12 pages, 21 figures, final version to appear in Phys. Rev.
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