86 research outputs found

    Comparative study of Line Scan and Flying Line Active IR Thermography operated with a 6-axis robot

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    International audienceIn this paper, two Non Destructive Testing approaches by active infrared thermography mounted on a 6-axis robot are presented and studied. Data acquisition and thermal excitation is carried out dynamically over various CFRP specimens with increasing geometry complexity, from planar, to convex and concave shapes. An automated procedure is proposed to reconstruct thermal image sequences issued from the two scanning procedure studied: Line Scan and Flying Line procedures. Defective area detection is performed by image processing and an inverse technique based on thermal quadrupole method is used to map the depth of flaws. Results obtained are discussed and perspectives are addressed

    Skeletal Muscle Phenotypically Converts and Selectively Inhibits Metastatic Cells in Mice

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    Skeletal muscle is rarely a site of malignant metastasis; the molecular and cellular basis for this rarity is not understood. We report that myogenic cells exert pronounced effects upon co-culture with metastatic melanoma (B16-F10) or carcinoma (LLC1) cells including conversion to the myogenic lineage in vitro and in vivo, as well as inhibition of melanin production in melanoma cells coupled with cytotoxic and cytostatic effects. No effect is seen with non-tumorigenic cells. Tumor suppression assays reveal that the muscle-mediated tumor suppressor effects do not generate resistant clones but function through the down-regulation of the transcription factor MiTF, a master regulator of melanocyte development and a melanoma oncogene. Our findings point to skeletal muscle as a source of therapeutic agents in the treatment of metastatic cancers
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