Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci

Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the optical power of the eye and its axial length that causes object images to be focused off the retina. The two major subtypes of RE are myopia (nearsightedness) and hyperopia (farsightedness), which represent opposite ends of the distribution of the quantitative measure of spherical refraction. We performed a fixed effects meta-analysis of genome-wide association results of myopia and hyperopia from 9 studies of European-derived populations: AREDS, KORA, FES, OGP-Talana, MESA, RSI, RSII, RSIII and ERF. One genome-wide significant region was observed for myopia, corresponding to a previously identified myopia locus on 8q12 (p = 1.25610-8), which has been reported by Kiefer et al. as significantly associated with myopia age at onset and Verhoeven et al. as significantly associated to mean spherical-equivalent (MSE) refractive error. We observed two genomewide significant association

Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract

Nuclear cataract is the most common type of age-related cataract and a leading cause of blindness worldwide. Age-related nuclear cataract is heritable (h2 = 0.48), but little is known about specific genetic factors underlying this condition. Here we report findings from the largest to date multi-ethnic meta-analysis of genome-wide association studies (discovery cohort N = 14,151 and replication N = 5299) of the International Cataract Genetics Consortium. We confirmed the known genetic association of CRYAA (rs7278468, P = 2.8 × 10−16) with nuclear cataract and identified five new loci associated with this disease: SOX2-OT (rs9842371, P = 1.7 × 1

Pneumatic displacement of submacular hemorrhage [6] (multiple letters)

Ophthalmology107122118-2120OPHT

The association among smoking, heavy drinking, and chronic kidney disease

10.1093/aje/kwj173American Journal of Epidemiology1643263-271AJEP

The prevalence and 5-year incidence of ocular trauma: The Beaver Dam Eye Study

10.1016/S0161-6420(00)00390-0Ophthalmology107122196-2202OPHT

Refractive errors and 10-year incidence of age-related maculopathy

Investigative Ophthalmology and Visual Science4392869-2873IOVS

The relation of retinal microvascular characteristics to age-related eye disease: The Beaver Dam eye study

10.1016/j.ajo.2003.10.020American Journal of Ophthalmology1373435-444AJOP

A prospective cohort study of retinal arteriolar narrowing and mortality

10.1093/aje/kwh119American Journal of Epidemiology1599819-825AJEP