3,458 research outputs found
A Study of Integration: The Role of Sensus Communis in Integrating Disciplinary Knowledge
Integration is an important notion for interdisciplinary studies. Achieving this shows that the interdisciplinary learner has successfully understood the commonalities among disciplines, as well as exercised crucial cognitive skills. This chapter attempts to elucidate how students integrated various disciplinary perspectives in the interdisciplinary course, Weird Science: Interpreting and Redefining Humanity. The study uses Hans-Georg Gadamer’s notion of the sensus communis to clarify how it was that students were processing and accomplishing the goal of integrating different disciplinary perspectives as evidenced in class observation, discussion, and especially student papers. The study demonstrates the ways in which common sense knowledge conditions and enables the integration process
Slow light in paraffin-coated Rb vapor cells
We present preliminary results from an experimental study of slow light in
anti-relaxation-coated Rb vapor cells, and describe the construction and
testing of such cells. The slow ground state decoherence rate allowed by coated
cell walls leads to a dual-structured electromagnetically induced transparency
(EIT) spectrum with a very narrow (<100 Hz) transparency peak on top of a broad
pedestal. Such dual-structure EIT permits optical probe pulses to propagate
with greatly reduced group velocity on two time scales. We discuss ongoing
efforts to optimize the pulse delay in such coated cell systems.Comment: 6 pages, 6 figures, submitted to Journal of Modern Optic
Comprehensive transcriptome-wide analysis of spliceopathy correction of myotonic dystrophy using CRISPR-Cas9 in iPSCs-derived cardiomyocytes
CTG repeat expansion (CTGexp) is associated with aberrant
alternate splicing that contributes to cardiac dysfunction in
myotonic dystrophy type 1 (DM1). Excision of this CTGexp
repeat using CRISPR-Cas resulted in the disappearance of
punctate ribonuclear foci in cardiomyocyte-like cells derived
from DM1-induced pluripotent stem cells (iPSCs). This was
associated with correction of the underlying spliceopathy as
determined by RNA sequencing and alternate splicing analysis.
Certain genes were of particular interest due to their role in cardiac
development, maturation, and function (TPM4, CYP2J2,
DMD, MBNL3, CACNA1H, ROCK2, ACTB) or their association
with splicing (SMN2, GCFC2, MBNL3). Moreover, while
comparing isogenic CRISPR-Cas9-corrected versus non-corrected
DM1 cardiomyocytes, a prominent difference in the
splicing pattern for a number of candidate genes was apparent
pertaining to genes that are associated with cardiac function
(TNNT, TNNT2, TTN, TPM1, SYNE1, CACNA1A, MTMR1,
NEBL, TPM1), cellular signaling (NCOR2, CLIP1, LRRFIP2,
CLASP1, CAMK2G), and other DM1-related genes (i.e.,
NUMA1, MBNL2, LDB3) in addition to the disease-causing
DMPK gene itself. Subsequent validation using a selected
gene subset, including MBNL1, MBNL2, INSR, ADD3, and
CRTC2, further confirmed correction of the spliceopathy
following CTGexp repeat excision. To our knowledge, the present
study provides the first comprehensive unbiased transcriptome-
wide analysis of the differential splicing landscape in
DM1 patient-derived cardiac cells after excision of the CTGexp
repeat using CRISPR-Cas9, showing reversal of the abnormal
cardiac spliceopathy in DM1
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In-street wind direction variability in the vicinity of a busy intersection in central London
We present results from fast-response wind measurements within and above a busy intersection between two street canyons (Marylebone Road and Gloucester Place) in Westminster, London taken as part of the DAPPLE (Dispersion of Air Pollution and Penetration into the Local Environment; www.dapple.org.uk) 2007 field campaign. The data reported here were collected using ultrasonic anemometers on the roof-top of a building adjacent to the intersection and at two heights on a pair of lamp-posts on opposite sides of the intersection. Site characteristics, data analysis and the variation of intersection flow with the above-roof wind direction (θref) are discussed. Evidence of both flow channelling and recirculation was identified within the canyon, only a few metres from the intersection for along-street and across-street roof-top winds respectively. Results also indicate that for oblique rooftop flows, the intersection flow is a complex combination of bifurcated channelled flows, recirculation and corner vortices. Asymmetries in local building geometry around the intersection and small changes in the background wind direction (changes in 15-min mean θref of 5–10 degrees) were also observed to have profound influences on the behaviour of intersection flow patterns. Consequently, short time-scale variability in the background flow direction can lead to highly scattered in-street mean flow angles masking the true multi-modal features of the flow and thus further complicating modelling challenges
Emergence of Superlattice Dirac Points in Graphene on Hexagonal Boron Nitride
The Schr\"odinger equation dictates that the propagation of nearly free
electrons through a weak periodic potential results in the opening of band gaps
near points of the reciprocal lattice known as Brillouin zone boundaries.
However, in the case of massless Dirac fermions, it has been predicted that the
chirality of the charge carriers prevents the opening of a band gap and instead
new Dirac points appear in the electronic structure of the material. Graphene
on hexagonal boron nitride (hBN) exhibits a rotation dependent Moir\'e pattern.
In this letter, we show experimentally and theoretically that this Moir\'e
pattern acts as a weak periodic potential and thereby leads to the emergence of
a new set of Dirac points at an energy determined by its wavelength. The new
massless Dirac fermions generated at these superlattice Dirac points are
characterized by a significantly reduced Fermi velocity. The local density of
states near these Dirac cones exhibits hexagonal modulations indicating an
anisotropic Fermi velocity.Comment: 16 pages, 6 figure
Characteristic Energy of the Coulomb Interactions and the Pileup of States
Tunneling data on crystals confirm
Coulomb interaction effects through the dependence of the
density of states. Importantly, the data and analysis at high energy, E, show a
pileup of states: most of the states removed from near the Fermi level are
found between ~40 and 130 meV, from which we infer the possibility of universal
behavior. The agreement of our tunneling data with recent photoemission results
further confirms our analysis.Comment: 4 pages, 4 figures, submitted to PR
Evaluation of the Ez-HBT Helicobacter blood test to establish Helicobacter pylori eradication
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73012/1/j.1365-2036.2005.02655.x.pd
The european water framework directive facing current challenges: recommendations for a more efficient biological assessment of inland surface waters
High quality water is vital for human life, and ensuring its availability is a basic requirement and a
major societal aim. The Water Framework Directive (WFD; 2000/60/EC) is a key piece of legislation
for the protection and sustainable use of water in the European Union. In this work we briefly review
the WFD directive and the current status of European inland surface waters. Additionally, we
summarize major challenges and threats for the biological assessment of inland surface waters
under climate change effects and invasion by alien species, and highlight the emerging tools
and approaches that might help improve biological assessments, including molecular indices
based on environmental DNA (eDNA), to new data from the Earth Observation programmes, and
data-sharing platforms. Finally, we present recommendations to improve monitoring systems
and assessments in the context of the WFD. Developments in this field may increase the
likelihood of assuring high quality water for societyFRESHING Project funded by the Portuguese Foundation for Science
and Technology (FCT) and COMPETE (PTDC/AAG-MAA/
2261/2014 – POCI-01-0145-FEDER-356 016824). AFF,
AGR, and JPR were supported by FRESHING. FMSM was
supported by FCT grant SFRH/BD/104703/2014. MJF was
supported by the strategic project UID/MAR/04292/2013
granted to MAR
Interdisciplinary collaborations in the creation of digital dance and performance: A critical examination
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