General N = 1 Supersymmetric Flux Vacua of (Massive) Type IIA String Theory

We derive conditions for the existence of four-dimensional \N=1 supersymmetric flux vacua of massive type IIA string theory with general supergravity fluxes turned on. For an SU(3) singlet Killing spinor, we show that such flux vacua exist only when the internal geometry is nearly-K\"ahler. The geometry is not warped, all the allowed fluxes are proportional to the mass parameter and the dilaton is fixed by a ratio of (quantized) fluxes. The four-dimensional cosmological constant, while negative, becomes small in the vacuum with the weak string coupling.Comment: 4 page

BPS-Saturated Bound States of Tilted P-Branes in Type II String Theory

We found BPS-saturated solutions of M-theory and Type II string theory which correspond to (non-marginally) bound states of p-branes intersecting at angles different from pi/2. These solutions are obtained by starting with a BPS marginally bound (orthogonally) intersecting configurations of two p-branes (e.g, two four-branes of Type II string theory), performing a boost transformation at an angle with respect to the world-volume of the configuration, performing T-duality transformation along the boost-direction, S-duality transformation, and T- transformations along the direction perpendicular to the boost transformation. The resulting configuration is non-marginally bound BPS-saturated solution whose static metric possesses the off-diagonal term which cannot be removed by a coordinate transformation, and thus signifies an angle (different from pi/2) between the resulting intersecting p-branes. Additional new p-branes are bound to this configuration, in order to ensure the stability of such a static, tilted configuration.Comment: 11 pages, Latex with two postscript figures, minor corrections, version to appear in Phys. Rev.

Bent BPS domain walls of D=5 N=2 gauged supergravity coupled to hypermultiplets

Within D=5 N=2 gauged supergravity coupled to hypermultiplets we derive consistency conditions for BPS domain walls with constant negative curvature on the wall. For such wall solutions to exist, the covariant derivative of the projector, governing the constraint on the Killing spinor, has to be non-zero and proportional to the cosmological constant on the domain walls. We also prove that in this case solutions of the Killing spinor equations are solutions of the equations of motion. We present explicit, analytically solved examples of such domain walls, employing the universal hypermultiplet fields. These examples involve the running of two scalar fields and the space-time in the transverse direction that is cut off at a critical distance, governed by the magnitude of the negative cosmological constant on the wall.Comment: 18 pages, Late

Gross nitrogen transformation rates do not support previously described BNI capacities of selected Brachiaria genotypes

Nitrification is one of the key processes leading to water contamination and greenhouse gas emissions (N2O) in pasture systems. As vast areas of tropical pastures are nitrogen (N) limited, grasses from the Brachiaria genus have adapted to reduce N losses and increase N use efficiency by releasing substances capable of biological nitrification inhibition (BNI) in the rhizosphere. Although the release of BNI compounds and its impact on N2O emissions and net nitrification rates in soil have been studied, the impact of BNI on gross nitrogen transformation rates has not been addressed, despite its relevance to mechanistic understanding of this phenomena

A Multicenter Experience with Long-Acting Somatostatin Analogues in Patients with Congenital Hyperinsulinism

Background/Aims: Congenital hyperinsulinism (CHI) is a rare disease characterized by recurrent severe hypoglycemia. In the diffuse form of CHI, pharmacotherapy is the preferred choice of treatment. Long-acting somatostatin analogues have been used in children as off-label medication. However, the efficacy, outcomes, and adverse effect profiles of long-acting somatostatin analogues have not been described in multicentered studies. The aim of this retrospective study is to summarize the experience with long-acting somatostatin analogues in a large group of children with CHI. Methods: Data were obtained retrospectively from 27 patients with CHI who received long-acting somatostatin analogues in 6 different centers in Europe. These included information on glycemic stability, auxology, and adverse effect profile in clinical follow-up assessments. Results: Blood glucose control improved in most patients (89%). No life-threatening side effects occurred. Thirteen patients (48%) experienced side effects; in 3 patients (11%), the side effects were the main reason for discontinuation of the treatment. The most frequent side effect was elevated liver enzymes (n = 10, 37%). Conclusion: Long-acting somatostatin analogues are effective in glycemic control of patients with CHI. However, in 37% of all patients increased liver enzymes were observed. It is important to monitor liver function in all patients receiving long-acting somatostatin analogue therapy. (C) 2017 S. Karger AG, Base

Time-dependent backgrounds from supergravity with gauged non-compact R-symmetry

We obtain a general class of time-dependent, asymptotically de Sitter backgrounds which solve the first order bosonic equations that extremize the action for supergravity with gauged non-compact $R$-symmetry. These backgrounds correspond only to neutral fields with the correct sign of kinetic energy. Within N=2 five-dimensional supergravity with vector-superfields we provide examples of multi-centered charged black holes in asymptotic de Sitter space, whose spatial part is given by a time-dependent hyper-K\"ahler space. Reducing these backgrounds to four dimensions yields asymptotically de Sitter multi-centered charged black hole backgrounds and we show that they are related to an instanton configuration by a massive T-duality over time. Within N=2 gauged supergravity in four (and five)-dimensions with hyper-multiplets there could also be neutral cosmological backgrounds that are regular and correspond to the different de Sitter spaces at early and late times.Comment: 28 pages, Latex; minor changes and add reference

Circle of Willis variants and their association with outcome in patients with middle cerebral artery-M1-occlusion stroke.

BACKGROUND An incomplete circle of Willis (CoW) has been associated with a higher risk of stroke and might affect collateral flow in large vessel occlusion (LVO) stroke. We aimed to investigate the distribution of CoW variants in a LVO stroke and transient ischemic attack (TIA) cohort and analyze their impact on 3-month functional outcome. METHODS CoW anatomy was assessed with time-of-flight magnetic resonance angiography (TOF-MRA) in 193 stroke patients with acute middle cerebral artery (MCA)-M1-occlusion receiving endovascular treatment (EVT) and 73 TIA patients without LVO. The main CoW variants were categorized into four vascular models of presumed collateral flow via the CoW. RESULTS 82.4% (n = 159) of stroke and 72.6% (n = 53) of TIA patients had an incomplete CoW. Most variants affected the posterior circulation (stroke: 77.2%, n = 149; TIA: 58.9%, n = 43; p = 0.004). Initial stroke severity defined by the National Institutes of Health Stroke Scale (NIHSS) on admission was similar for patients with and without CoW variants. CoW integrity did not differ between groups with favorable (modified Rankin Scale [mRS]): 0-2) and unfavorable (mRS: 3-6) 3-month outcome. However, we found trends towards a higher mortality in patients with any type of CoW variant (p = 0.08) and a higher frequency of incomplete CoW among patients dying within 3 months after stroke onset (p = 0.119). In a logistic regression analysis adjusted for the potential confounders age, sex and atrial fibrillation, neither the vascular models nor anterior or posterior variants were independently associated with outcome. CONCLUSION Our data provide no evidence for an association of CoW variants with clinical outcome in LVO stroke patients receiving EVT

Circle of Willis variants and their association with outcome in patients with middle cerebral artery-M1-occlusion stroke

BACKGROUND: An incomplete circle of Willis (CoW) has been associated with a higher risk of stroke and might affect collateral flow in large vessel occlusion (LVO) stroke. We aimed to investigate the distribution of CoW variants in a LVO stroke and transient ischemic attack (TIA) cohort and analyze their impact on 3-month functional outcome. METHODS: CoW anatomy was assessed with time-of-flight magnetic resonance angiography (TOF-MRA) in 193 stroke patients with acute middle cerebral artery (MCA)-M1-occlusion receiving endovascular treatment (EVT) and 73 TIA patients without LVO. The main CoW variants were categorized into four vascular models of presumed collateral flow via the CoW. RESULTS: 82.4% (n = 159) of stroke and 72.6% (n = 53) of TIA patients had an incomplete CoW. Most variants affected the posterior circulation (stroke: 77.2%, n = 149; TIA: 58.9%, n = 43; p = 0.004). Initial stroke severity defined by the National Institutes of Health Stroke Scale (NIHSS) on admission was similar for patients with and without CoW variants. CoW integrity did not differ between groups with favorable (modified Rankin Scale [mRS]): 0-2) and unfavorable (mRS: 3-6) 3-month outcome. However, we found trends towards a higher mortality in patients with any type of CoW variant (p = 0.08) and a higher frequency of incomplete CoW among patients dying within 3 months after stroke onset (p = 0.119). In a logistic regression analysis adjusted for the potential confounders age, sex and atrial fibrillation, neither the vascular models nor anterior or posterior variants were independently associated with outcome. CONCLUSION: Our data provide no evidence for an association of CoW variants with clinical outcome in LVO stroke patients receiving EVT

Vertigo and dizziness in adolescents: Risk factors and their population attributable risk

Objectives: To assess potential risk factors for vertigo and dizziness in adolescents and to evaluate their variability by different vertigo types. The role of possible risk factors for vertigo and dizziness in adolescents and their population relevance needs to be addressed in order to design preventive strategies. Study design: The study population consisted of 1482 school-children between the age of 12 and 19 years, who were instructed to fill out a questionnaire on different vertigo types and related potential risk factors. The questionnaire specifically asked for any vertigo, spinning vertigo, swaying vertigo, orthostatic dizziness, and unspecified dizziness. Further a wide range of potential risk factors were addressed including gender, stress, muscular pain in the neck and shoulder region, sleep duration, migraine, coffee and alcohol consumption, physical activity and smoking. Results: Gender, stress, muscular pain in the neck and shoulder region, sleep duration and migraine were identified as independent risk factors following mutual adjustment: The relative risk was 1.17 [1.10 - 1.25] for female sex, 1.07 [1.02 - 1.13] for stress, 1.24 [1.17 - 1.32] for muscular pain, and 1.09 [1.03 - 1.14] for migraine. The population attributable risk explained by these risk factors was 26%, with muscular pain, stress, and migraine accounting for 11%, 4%, and 3% respectively. Conclusion: Several established risk factors in adults were also identified in adolescents. Risk factors amenable to prevention accounted for 17% of the total population risk. Therefore, interventions targeting these risk factors may be warranted

ESTRO ACROP and SIOPE recommendations for myeloablative total body irradiation in children

Background and purpose: Myeloablative Total Body Irradiation (TBI) is an important modality in conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), especially in children with high-risk acute lymphoblastic leukemia (ALL). TBI practices are heterogeneous and institution-specific. Since TBI is associated with multiple late adverse effects, recommendations may help to standardize practices and improve the outcome versus toxicity ratio for children. Material and methods: The European Society for Paediatric Oncology (SIOPE) Radiotherapy TBI Working Group together with ESTRO experts conducted a literature search and evaluation regarding myeloablative TBI techniques and toxicities in children. Findings were discussed in bimonthly virtual meetings and consensus recommendations were established. Results: Myeloablative TBI in HSCT conditioning is mostly performed for high-risk ALL patients or patients with recurring hematologic malignancies. TBI is discouraged in children <3–4 years old because of increased toxicity risk. Publications regarding TBI are mostly retrospective studies with level III–IV evidence. Preferential TBI dose in children is 12–14.4 Gy in 1.6–2 Gy fractions b.i.d. Dose reduction should be considered for the lungs to <8 Gy, for the kidneys to ≤10 Gy, and for the lenses to <12 Gy, for dose rates ≥6 cGy/min. Highly conformal techniques i.e. TomoTherapy and VMAT TBI or Total Marrow (and/or Lymphoid) Irradiation as implemented in several centers, improve dose homogeneity and organ sparing, and should be evaluated in studies. Conclusions: These ESTRO ACROP SIOPE recommendations provide expert consensus for conventional and highly conformal myeloablative TBI in children, as well as a supporting literature overview of TBI techniques and toxicities