Specific features of inflammatory bowel disease iu Zadar County

Cilj istraživanja: utvrditi incidenciju i prevalenciju upalnih bolesti crijeva (Crohnova bolest i ulcerozni kolitis) u pučanstvu Zadarske županije u razdoblju od 2000 - 2010 godine, analizirati fenotipove obje bolesti, ustanoviti učestalost komlikacija, te istražiti utjecaj potencijalnih čimbenika rizika okoliša. Nacrt studije: retrospektivno – prospektivna epidemiološka studija Ispitanici i metode: u studiju je uključeno 397 pacijenata s upalnim bolestima crijeva, 243 muškarca i 154 žene, koji svi žive na području Zadarske županije. Za procjenu čimbenika rizika je formirana kontrolna skupina od 1000 zdravih dobrovoljaca koji također žive na području Zadarske županije. Za svakog oboljelog ispunjena su dva protokola, za incidenciju i prevalenciju upalnih bolesti crijeva. Fenotip Crohnove bolesti i ulceroznog kolitisa određen je prema Montrealskoj klasifikaciji upalnih bolesti crijeva. Rezultati: Pokazana je blaga predominacija ulceroznog kolitisa nad Crohnovom bolesti, te veći broj oboljelih muškaraca kod obje bolesti. Godišnja stopa incidencije za razdoblje 2000-2010 za ulcerozni kolitis iznosi 8,1/100.000 stanovnika, a za Crohnovu bolest 8,3/100.000. Prevalencija na kraju 2010 godine za ulcerozni kolitis iznosi 128,39/100.000 stanovnika, a za Crohnovu bolest 106,5/100.000 stanovnika. Bolesnici s Crohnovom bolesti su mlađi (31,9 godina) od bolesnika s ulceroznim kolitisom (42,4 godine) u trenutku postavljanja dijagnoze. Kod bolesnika s ulceroznim kolitisom najčešće je zahvaćeno cijelo debelo crijevo (fenotip E3). Bolesnici s Crohnovom bolesti su najčešće stari između 17 i 40 godina (fenotip A2), najčešće je zahvaćen terminalni ileum (L1), te imaju nekomplicirani tijek bolesti (B1). Komplikacije bolesti su češće kod Crohnove bolesti. Nađena je statistički značajna povezanost upalnih bolesti crijeva i pušenja, apendektomije i cijepljenja protiv ospica, dok te povezanosti ne postoji s tonzilektomijom, uzimanjem oralnih kontraceptiva i preboljelim ospicama. Pušenje utječe na učestalost komplikacija kod bolesnika s Crohnovom bolesti. Statistički je značajna obiteljska agregacija upalnih bolesti crijeva. Zaključak: epidemiologija upalnih bolesti crijeva se najbolje uklapa u europski „model zapad-istok“. Dobiveni su točni brojčani podatci za jednu dalmatinsku županiju, koji mogu temelj za daljnja istraživanja.Aim of study: To determine the incidence and prevalence of inflammatory bowel disease (Crohn's disease and ulcerative colitis ) in the population of Zadar County in the period 2000-2010 , to analyse phenotypes of both diseases, to determine the frequency of complication, and explore the impact of potential enviromental risk factors. Study design : retrospective – prospective epidemiological study Patients and Methods : The study included 397 patients with inflammatory bowel disease , 243 men and 154 women , who all live in Zadar County . To assess risk factors formed a control group of 1,000 healthy volunteers who also live in Zadar County. For each patient met the two protocols , the incidence and prevalence of inflammatory bowel disease. Phenotype of Crohn`s disease and ulcerative colitis is determined by the Montreal classification of inflamatory bowel disease. Results : The higher the incidence of ulcerative colitis compared to Crohn's disease. In both diseases is increasing the number of male patients.. The annual incidence rate for the period 2000-2010 for ulcerative colitis is 8.1 / 100,000 inhabitans , while Crohn's disease is 8.3 / 100,000 . Prevalence at the end of 2010 for ulcerative colitis is 128,39 / 100,000 inhabitans , while Crohn's disease is 106,5/100.000 inhabitants. Patients with Crohn's disease were younger (31.9 years) than patients with ulcerative colitis (42.4 years) at the time of diagnosis. Patients with ulcerative colitis usually affected the entire colon (phenotype E3) . Patients with Crohn's disease are usually aged between 17 and 40 (phenotype A2) , the most affected is terminal ileum (L1), and have uncomplicated disease course (B1) . Complications of the disease are more common in Crohn's disease. Discovered connection between inflammatory bowel disease and smoking, appendectomy, and vaccination against measles, while not a proven link with tonsillectomy, oral contraceptives an measles in history . Smoking affects the incidence of complications in patients with Crohn's disease. There is a statistically significant family agggregation of inflamatory bowel disease. Conclusion: The epidemiology of inflammatory bowel disease can best fit into the European " model west-east ." Obtained are accurate numerical data for one Dalmatia County, which can be the basis for further research

Argon plasma coagulation and proton pump inhibitors in a female patient with Barrett\u27s esophagus

Opisan je slučaj liječenja Barrettovog jednjaka (BJ) argon plazma koagulacijom (APK), nakon neuspješnog liječenja dvostrukom dozom inhibitora protonske pumpe (IPP) po smjernicama. Dijagnoza je postavljena patohistološki iz bioptičkog uzorka. Nakon dva (04/07, 09/07) tretmana APK-om, došlo je do potpunog oporavka sluznice ezofagogastričnog (EG) spoja, što je potvrđeno patohistološkom analizom bioptičkog uzorka (PHD). Kontrolna ezofagogastroduodenoskopija (EGD) nakon godinu dana, uz biopsije sluznice, ponovo je potvrdila dijagnozu Barrettovog jednjaka, ali je regresija nastupila na terapiju inhibitorima protonske pumpe (IPP) u terapijskoj dozi. Posljednja EGD u 05/09, uz nalaz PHD, govori u prilog kroničnog gastritisa.A treatment of Barrett¢s esophagus by argon plasma coagulation (APC) in a female patient is described, after unsuccessful treatment with double dose of proton pump inhibitors (PPI¢s) following guidelines. The diagnosis is confirmed by pathohistological (PHD) tissue analysis, that is obtained by biopsy of esophagogastric (EG) junction. After double treatement by APC, control biopsy was performed, and pathohistological diagnosis was chronic gastritis. After one year, control biopsy confirmed again the diagnosis of Barrett esophagus. PPI¢s were given to the patient, and complete regression was confirmed by biopsy of EG junction

Size-Structure Relationship in Manufacturing Enterprises in Transition

The paper describes research on a size-structure relationship in manufacturing enterprises. The research was carried out in 30 manufacturing firms, mainly from the metalworking industry (seven oil and oil derivative processing companies) during the period from 1994 till 2006. Multiple correlation analysis indicated a positive relationship between a firm size and horizontal diversification, and also between a firm size and vertical diversification. The results showed that there was a high level of correlation between size and organizational structure in metalworking enterprises of a country in transition. The results of this study indicated that manufacturing enterprises of a country in transition followed a global trend of flat organizational structure, which increased enterprises’ flexibility and adaptability to changeable environmental factors

Clinical Expression of Inflammatory Bowel Diseases – A Retrospective Population-Based Cohort Study; Vukovarsko-Srijemska County, Croatia, 2010

Clinical characteristics of the cohort of 150 patients with inflammatory bowel diseases, ulcerative colitis (UC) and Crohn\u27s disease (CD), Vukovarsko-Srijemska County, Croatia, were retrospectively assessed. UC was clinically presented with frequent passage of bloody, slimy stools, while preferential symptoms of CD were fever, anemia and severe weight loss, differences reflecting longer duration of symptoms prior to the diagnosis, in patients with CD. The prevalent disease localisations, in patients with UC, were the rectum and the left colon and the anorectum, while the prevailing phenotype, in patients with CD, corresponded with younger adult age at disease onset, ileocolonic localization and stricturing dis- ease behavior. Intestinal complications, including perforation, fistula, abscess and ileus, were more prevalent in patients with CD. Of extraintestinal complications, only ankylosing spondylitis and erythema nodosum, reached marginally sig- nificant differences, in favor to patients with CD. Shortcomings of this study include the lack of associations and the time-dependent disease projections

Epidemiology and Clinical Presentation of Inflammatory Bowel Disease in Zadar County, Croatia

Results of the retrospective, population-based study, 2000–2010, on inflammatory bowel disease, ulceratice colitis (UC) and Crohn\u27s disease (CD), from Zadar County, have been presented and compared with world experience and com- parative data from Primorsko-Goranska and Vukovarsko-Srijemska Counties. The average incidence rates (per 100 000) were 8.2 and 8.4, for UC and CD, respectively. Prevalence rates, at the end of the follow up, were 133.9 for UC and 111 for CD. Constant increase in the incidence rates for both, UC and CD, have been recorded, for CD more prominently in the second part of the follow up, 2006–2010. Prevalence rates have being continuosly rased for both diseases, data for UC ex- ceeding that for CD. Results of data comparison among the counties contribute in favour to the hypothesis of Zadar County as a rapidly developing area and strongly argue against the existence of the North-South gradient between Vukovarsko-Srijemska and Zadar Counties

Argon plasma coagulation and proton pump inhibitors in a female patient with Barrett\u27s esophagus

Opisan je slučaj liječenja Barrettovog jednjaka (BJ) argon plazma koagulacijom (APK), nakon neuspješnog liječenja dvostrukom dozom inhibitora protonske pumpe (IPP) po smjernicama. Dijagnoza je postavljena patohistološki iz bioptičkog uzorka. Nakon dva (04/07, 09/07) tretmana APK-om, došlo je do potpunog oporavka sluznice ezofagogastričnog (EG) spoja, što je potvrđeno patohistološkom analizom bioptičkog uzorka (PHD). Kontrolna ezofagogastroduodenoskopija (EGD) nakon godinu dana, uz biopsije sluznice, ponovo je potvrdila dijagnozu Barrettovog jednjaka, ali je regresija nastupila na terapiju inhibitorima protonske pumpe (IPP) u terapijskoj dozi. Posljednja EGD u 05/09, uz nalaz PHD, govori u prilog kroničnog gastritisa.A treatment of Barrett¢s esophagus by argon plasma coagulation (APC) in a female patient is described, after unsuccessful treatment with double dose of proton pump inhibitors (PPI¢s) following guidelines. The diagnosis is confirmed by pathohistological (PHD) tissue analysis, that is obtained by biopsy of esophagogastric (EG) junction. After double treatement by APC, control biopsy was performed, and pathohistological diagnosis was chronic gastritis. After one year, control biopsy confirmed again the diagnosis of Barrett esophagus. PPI¢s were given to the patient, and complete regression was confirmed by biopsy of EG junction

Implantation of biliary and pancreatic stents - an overview and our experience

Bilijarni stentovi široko se koriste u terapiji malignih i benignih opstrukcija bilijarnoga trakta, poglavito ako su praćene opstruktivnim ikterusom. U Općoj bolnici Zadar s implantacijom bilijarnih stentova započeli smo 1995. godine. Ovdje iznosimo opći pregled i vlastita iskustva kod implantacije.Biliary stents are widely used in malignant and benign obstruction of the biliary tract, particularly if accompanied by obstructive icterus. We started implanting biliary stents in Zadar General Hospital in 1995. Here we are presenting a general overview and our experiences with stent implantation

Helicobacter Pylori Infection and Acute Myocardial Infarction

The aim of this investigation was to determine whether H. pylori infection is an independent risk factor for acutemyocardial infarction (AMI), determine is there a link between H. pylori infection and severity of disease. In this prospective, single centre study, were enrolled 100 patients with AMI and control group was consisted 93 healthy individuals. The results of this study showed no difference between H. pylori seropositivity distribution in the investigate and control group (29 vs. 26 %) and there was no significant difference on the severity of the disease. There was significant association in the patients with three and more risk factors, where the patients with lower blood pressure (124.4/77.4 vs. 145.9/87.7 mmHg) and better controled diabetes (HbA1c 6.1 % vs. 6.9 %) had greater risk for AMI if they are H. pylori seropositive. The largemulticentric trials would be needed to define a precise role of H. pylori infection on the developement of AMI

Incidence and Prevalence of Inflammatory Bowel Disease in Vukovarsko-Srijemska County, Croatia, 1991-2000 and 2001-2010: A Population-Based Study

Inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), were retrospectively assessed on the incidence and prevalence in Vukovarsko-Srijemska County, continental Croatia. There were a total number of 150 patients, 119 with UC and 31 with CD. Of them, 79.3% were patients with UC, indicating a predominant participation of UC in the sample. Comparisons between the period of surveillance, 2001-2010, and the decade before, 1991-2000, showed a significant increase in the incidence rates of both, UC and CD (UC 3.5, CD 0.95, 2001-2010, and UC 1.0, CD 0.45, 1991-2000). Comparison of this study with that performed in Primorsko-goranska County, coastal Croatia, revealed different distribution patterns of IBD. In Primorsko-goranska County, significantly higher incidence and prevalence rates of UC and CD and rather equal ratios between two diseases, were observed. The results are indicative of the differences between more developed Western and less developed Eastern parts of Croatia

Motivation for health behaviour: A predictor of adherence to balanced and healthy food across different coastal Mediterranean countries

This cross-sectional study aimed to assess perceptions of healthy food and motivation for health behaviour (MHB) in different Mediterranean countries. Multiple linear regression was used to identify the association between perception of healthy food and MHB in different countries. The highest MHB was observed in Portugal (median 38.0; IQR 7.0) and the lowest in Greece (median 34.0; IQR 8.0). Compared to Portuguese respondents, respondents from Croatia (ß=0.35; p < 0.001), Egypt (ß=0.24; p < 0.001), and Greece (ß=0.10; p < 0.001) had a higher probability of a better perception of healthy food. Slovenia respondents had reduced perception of healthy food (ß=-0.10; p < 0.001) and MHB (ß=-0.22; p < 0.001), despite higher adherence to a healthy diet (ß=0.22; p < 0.001). Lifestyle habits, such as physical exercise, showed a weak association with MHB (ß=0.14; p < 0.001) and adherence to healthy food (ß=0.18; p < 0.001). The presence of most chronic diseases was negatively associated with MHB. The association between the perception of healthy food, MHB, and adherence to a balanced and healthy diet across different countries could be useful for implementing strategies to promote healthy eating and prevent chronic diseases.info:eu-repo/semantics/publishedVersio