29 research outputs found
Professionalism as a Response to Right-Wing Populism? An Analysis of a Metajournalistic Discourse
The rise of right-wing populism in various countries poses difficult challenges to journalism: While populists themselves often accuse journalists of being biased against them or even of lying, critics allege that the mainstream media cover populism too extensively and normalize it. We reconstruct an understudied perspective on this problem: how journalists publicly discuss how to deal with right-wing populism. A qualitative analysis of metajournalistic discourses in the German press was conducted to identify typical narratives concerning the relationship between right-wing populism and the media, criticism of the way right-wing populism had been covered, and recommendations or demands concerning the "right" approach. Overall, the analysis reveals a rather uniform narrative about right-wing populism in Germany, and similar conceptions of how to deal with it were found. Most journalists make a clear distinction between the right and wrong way to cope with right-wing populism and emphasize the need for professional norms such as objectivity. Finally, we critically discuss some aspects that may inform metajournalistic reflection on how to cover right-wing populism, but that were absent from the debate
Molekulare Klassifikation gynÀkologischer Tumorerkrankungen am Beispiel des Endometrium- und Ovarialkarzinoms
Im Zentrum der vorliegenden Arbeit stand die Frage, ob sich die auf den Erkenntnissen des Cancer Genome Atlas Project (TCGA) basierende und mittlerweile in internationalen Leitlinien etablierte molekulare Klassifikation des Endometriumkarzinoms auf das endometrioide Ovarialkarzinom ĂŒbertragen lĂ€sst. Diese These lĂ€sst sich von der morphologischen NĂ€he der beiden EntitĂ€ten ableiten.
Die Fragestellung dieser Doktorarbeit ist insbesondere vor dem Hintergrund relevant, dass die verschiedenen histologischen Typen des Ovarialkarzinoms trotz deutlicher Unterschiede weiterhin ĂŒberwiegend unabhĂ€ngig ihres histologischen Typs behandelt werden. So zeichnet sich das endometrioide Ovarialkarzinom im Gegensatz zu den anderen histologischen Typen durch ein junges Erkrankungsalter der Patentinnen sowie ein frĂŒhes Krankheitsstadium und einen insgesamt gĂŒnstigen prognostischen Verlauf aus. Aus diesen klinisch bedeutsamen Unterschieden ergibt sich ein dringender Bedarf an histotyp-spezifischer Forschung.
Im Rahmen dieser Doktorarbeit war es möglich, ein bislang beispielloses Kollektiv von n=511 endometrioiden Ovarialkarzinomen zu etablieren. In Analogie zum Endometriumkarzinom wurde dieses Kollektiv mittels POLE-Mutationsanalyse sowie p53- und MMR-Immunhistochemie untersucht.
Die Ergebnisse der vorliegenden Arbeit legen nahe, dass sich die molekulare Klassifikation des Endometriumkarzinoms durchaus auf das endometrioide Ovarialkarzinom ĂŒbertragen lĂ€sst. Dies zeigt sich zum einen in der ersichtlichen Ăhnlichkeit der HĂ€ufigkeitsverteilungen der molekularen Subtypen in beiden EntitĂ€ten. Zum anderen war die aus den Ăberlebensanalysen des Endometriumkarzinoms bekannte prognostische Bedeutung der molekularen Subtypen auch fĂŒr das endometrioide Ovarialkarzinom signifikant nachweisbar. So konnte beispielsweise gezeigt werden, dass Patientinnen mit POLE-mutierten Ovarialkarzinomen eine 10-JahresĂŒberlebensrate von 100% hatten, wĂ€hrend Patientinnen mit p53-abnormalen Ovarialkarzinomen selbst im frĂŒhen Krankheitsstadium einen schlechten prognostischen Verlauf aufwiesen. Diese
Ergebnisse lieĂen sich auch in der Subgruppenanalyse der low-stage Karzinome bestĂ€tigen.
Schlussfolgernd könnte die molekulare Klassifikation endometrioider Ovarialkarzinome einen wichtigen Baustein in der histotyp-spezifischen und risikoadaptierten Beratung junger Patientinnen zur fertilitĂ€tserhaltenden Therapie oder Vermeidung einer iatrogenen Postmenopause darstellen. DarĂŒber hinaus könnten sich aus der NĂ€he zum Endometriumkarzinom weitere Forschungsfragen bezĂŒglich adjuvanter Therapien ergeben.
Dies könnte insbesondere fĂŒr junge Frauen nicht nur zu einer Verbesserung des Ăberlebens, sondern zu einer Verbesserung ihrer LebensqualitĂ€t beitragen
Third order nonlinear susceptibility of InN at near band-gap wavelengths
The authors report room-temperature measurements of the third order nonlinear susceptibility modulus â« (3) â« of thick (âŒ600 nm) InN layers. Transmission measurements provide a room-temperature value for the optical band gap of the samples slightly above 1500 nm. Third order nonlinear optical susceptibility has been measured using degenerate four wave mixing experiments at wavelengths near and above band gap. â« (3) â« values of (4.2-10) Ă 10-10 esu were measured at this wavelength range. The associated relaxation time of the generated population grating at 1500 nm was measured. The obtained value of 4.8 ps is consistent with a nonradiative recombination mechanism. © 2007 American Institute of Physics.Peer Reviewe
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Navigating protein landscapes with a machine-learned transferable coarse-grained model
The most popular and universally predictive protein simulation models employ
all-atom molecular dynamics (MD), but they come at extreme computational cost.
The development of a universal, computationally efficient coarse-grained (CG)
model with similar prediction performance has been a long-standing challenge.
By combining recent deep learning methods with a large and diverse training set
of all-atom protein simulations, we here develop a bottom-up CG force field
with chemical transferability, which can be used for extrapolative molecular
dynamics on new sequences not used during model parametrization. We demonstrate
that the model successfully predicts folded structures, intermediates,
metastable folded and unfolded basins, and the fluctuations of intrinsically
disordered proteins while it is several orders of magnitude faster than an
all-atom model. This showcases the feasibility of a universal and
computationally efficient machine-learned CG model for proteins
Nachweise seltener Spinnentiere in WĂ€ldern der Osteifel (Rheinland-Pfalz) (Araneae: Agelenidae, Araneidae, Linyphiidae, Theridiidae; Opiliones: Ischyropsalididae)
New species records for the Rhineland-Palatinate (Germany) from studies in forests from the Eastern Eifel region are reported. Ischyropsalis hellwigii hellwigii (Panzer, 1794) is recorded for the first time west of the river Rhine. Other remarkable species are Oreonetides quadridentatus (Wunderlich, 1972), to date known from only ten other localities in Germany, Coelotes atropos (Walckenaer, 1830), Gibbaranea omoeda (Thorell, 1870) and Robertus scoticus Jackson, 1914
Influence of forest management and microhabitat structure on the spider community regarding the autumnal aspect
FAS: introducing a service for avoiding faults in composite services
Due to copyright restrictions, the access to the full text of this article is only available via subscription.In service-oriented architectures, composite services depend on a set of partner services to perform the required tasks. These partner services may become unavailable due to system and/or network faults, leading to an increased error rate for the composite service. In this paper, we propose an approach to prevent the occurrence of errors that result from the unavailability of partner services. We introduce an external Web service, FAS (Fault Avoidance Service), to which composite services can register at will. After registration, FAS periodically checks the partner links, detects unavailable partner services, and updates the composite service with available alternatives. Thus, in case of a partner service error, the composite service will have been updated before invoking the partner service. We provide mathematical analysis regarding the error rate and the ratio of false positives with respect to the monitoring frequency of FAS for different partner service availabilities. We also provide empirical results regarding these metrics based on several tests we performed using the Amazon Elastic Compute Cloud