The composition of Ehrlich's salvarsan: Resolution of a century-old debate

Ehrlich introduced in 1910 the compound 3-amino-4-hydroxyphenylarsenic(I) [Salvarsan, arsphenamine, Ehrlich 606,] as a remedy for syphilis, a disease caused by the spirochaete bacterium Treponema pallidum. His methodical search for a specific curative for an identified disease can be regarded as the introduction of targeted chemotherapy

Hydrazine-1,2-diium bis­(3-carb­oxy-4-hy­droxy­benzene­sulfonate) tetra­hydrate

Reaction of 5-sulfosalicylic acid with hydrazine hydrate at pH = 1 results in the formation of the title hydrated salt, 0.5N2H6 2+·C7H5O6S−·2H2O. The hydrazinium dications lie on centres of inversion. They are located between 3-carb­oxy-4-hy­droxy­benzene­sulfonate anions, forming inter­molecular N—H⋯O hydrogen bonds with sulfonate ions and water mol­ecules of crystallisation. Further intra- and inter­molecular O—H⋯O hydrogen bonds are observed in the crystal structure

Metal–organic fireworks: MOFs as integrated structural scaffolds for pyrotechnic materials

A new approach to formulating pyrotechnic materials is presented whereby constituent ingredients are bound together in a solid-state lattice. This reduces the batch inconsistencies arising from the traditional approach of combining powders by ensuring the key ingredients are ‘mixed’ in appropriate quantities and are in intimate contact. Further benefits of these types of material are increased safety levels as well as simpler logistics, storage and manufacture. A systematic series of new frameworks comprising fuel and oxidiser agents (group 1 and 2 metal nodes & terephthalic acid derivatives as linkers) has been synthesised and structurally characterised. These new materials have been assessed for pyrotechnic effect by calorimetry and burn tests. Results indicate that these materials exhibit the desired pyrotechnic material properties and the effect can be correlated to the dimensionality of the structure. A new approach to formulating pyrotechnic materials is proposed whereby constituent ingredients are bound together in a solid-state lattice. A series of Metal–organic framework frameworks comprising fuel and oxidiser agents exhibits the desired properties of a pyrotechnic material and this effect is correlated to the dimensionality of the structure