Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels

Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and the phosphodiesterases which degrade these compounds. In this paper, we employ a systems biology approach to develop mathematical models of these networks that, for the first time, take into account the different biochemical properties of the isoforms involved. To investigate the mechanisms underlying the joint regulation of cAMP and cGMP, we apply our models to analyse the regulation of cilia beat frequency in Paramecium by Ca(2+). Based on our analysis of these models, we propose that the diversity of isoform combinations that occurs in living cells provides an explanation for the huge variety of intracellular processes that are dependent on these networks. The inclusion of both G-protein receptor and Ca(2+)-dependent regulation of AC in our models allows us to propose a new explanation for the switching properties of G-protein subunits involved in nucleotide regulation. Analysis of the models suggests that, depending on whether the G-protein subunit is bound to AC, Ca(2+) can either activate or inhibit AC in a concentration-dependent manner. The resulting analysis provides an explanation for previous experimental results that showed that alterations in Ca(2+) concentrations can either increase or decrease cilia beat frequency over particular Ca(2+) concentration ranges

Implications of observed neutrinoless double beta decay

Recently a positive indication of the neutrinoless double beta decay has been announced. We study the implications of this result taking into consideration earlier results on atmospheric neutrinos and solar neutrinos. We also include in our discussions the recent results from SNO and K2K. We point out that on the confidence level given for the double beta signal, the neutrino mass matrices are now highly constrained. All models predicting Dirac masses are ruled out and leptogenesis becomes a natural choice. Only the degenerate and the inverted hierarchical solutions are allowed for the three generation Majorana neutrinos. In both these cases we find that the radiative corrections destabilize the solutions and the LOW, VO and Just So solutions of the solar neutrinos are ruled out. For the four generation case only the inverted hierarchical scenario is allowed.Comment: 16 pages, 2 postscript figure

Latest Results from the Heidelberg-Moscow Double Beta Decay Experiment

New results for the double beta decay of 76Ge are presented. They are extracted from Data obtained with the HEIDELBERG-MOSCOW, which operates five enriched 76Ge detectors in an extreme low-level environment in the GRAN SASSO. The two neutrino accompanied double beta decay is evaluated for the first time for all five detectors with a statistical significance of 47.7 kg y resulting in a half life of (T_(1/2))^(2nu) = [1.55 +- 0.01 (stat) (+0.19) (-0.15) (syst)] x 10^(21) years. The lower limit on the half-life of the 0nu beta-beta decay obtained with pulse shape analysis is (T_(1/2))^(0_nu) > 1.9 x 10^(25) [3.1 x 10^(25)] years with 90% C.L. (68% C.L.) (with 35.5 kg y). This results in an upper limit of the effective Majorana neutrino mass of 0.35 eV (0.27 eV). No evidence for a Majoron emitting decay mode or for the neutrinoless mode is observed.Comment: 14 pages, revtex, 6 figures, Talk was presented at third International Conference ' Dark Matter in Astro and Particle Physics' - DARK2000, to be publ. in Proc. of DARK2000, Springer (2000). Please look into our HEIDELBERG Non-Accelerator Particle Physics group home page: http://www.mpi-hd.mpg.de/non_acc

Threshold Effects on Quasi-degenerate Neutrinos with High-scale Mixing Unification

We consider threshold effects on neutrino masses and mixings in a recently proposed model for understanding large solar and atmospheric mixing angles using radiative magnification for the case of quasi-degenerate neutrinos. We show that the magnitude of the threshold effects is sufficient to bring concordance between the predictions of this model and latest data from ${\rm KamLAND}$ and ${\rm SNO}$ on observations of neutrino oscillations.Comment: Four pages, no figure

Nuclear deformation and neutrinoless double-β\beta decay of 94,96^{94,96}Zr, 98,100^{98,100}Mo, 104^{104}Ru, 110^{110}Pd, 128,130^{128,130}Te and 150^{150}Nd nuclei in mass mechanism

The $(\beta ^{-}\beta ^{-})_{0\nu}$ decay of $^{94,96}$Zr, $^{98,100}$Mo, $^{104}$Ru, $^{110}$Pd, $^{128,130}$Te and $^{150}$Nd isotopes for the $0^{+}\to 0^{+}$ transition is studied in the Projected Hartree-Fock-Bogoliubov framework. In our earlier work, the reliability of HFB intrinsic wave functions participating in the $\beta ^{-}\beta ^{-}$ decay of the above mentioned nuclei has been established by obtaining an overall agreement between the theoretically calculated spectroscopic properties, namely yrast spectra, reduced $B(E2$:$0^{+}\to 2^{+})$ transition probabilities, quadrupole moments $Q(2^{+})$, gyromagnetic factors $g(2^{+})$ as well as half-lives $T_{1/2}^{2\nu}$ for the $0^{+}\to 0^{+}$ transition and the available experimental data. In the present work, we study the $(\beta ^{-}\beta ^{-})_{0\nu}$ decay for the $0^{+}\to 0^{+}$ transition in the mass mechanism and extract limits on effective mass of light as well as heavy neutrinos from the observed half-lives $T_{1/2}^{0\nu}(0^{+}\to 0^{+})$ using nuclear transition matrix elements calculated with the same set of wave functions. Further, the effect of deformation on the nuclear transition matrix elements required to study the $(\beta ^{-}\beta ^{-})_{0\nu}$ decay in the mass mechanism is investigated. It is noticed that the deformation effect on nuclear transition matrix elements is of approximately same magnitude in $(\beta ^{-}\beta ^{-})_{2\nu}$ and $(\beta ^{-}\beta ^{-})_{0\nu}$ decay.Comment: 15 pages, 1 figur

High sensitivity GEM experiment on double beta decay of 76-Ge

The GEM project is designed for the next generation 2 beta decay experiments with 76-Ge. One ton of ''naked'' HP Ge detectors (natural at the first GEM-I phase and enriched in 76-Ge to 86% at the second GEM-II stage) are operating in super-high purity liquid nitrogen contained in the Cu vacuum cryostat (sphere with diameter 5 m). The latest is placed in the water shield. Monte Carlo simulation evidently shows that sensitivity of the experiment (in terms of the T1/2 limit for neutrinoless 2 beta decay) is 10^27 yr with natural HP Ge crystals and 10^28 yr with enriched ones. These bounds corresponds to the restrictions on the neutrino mass less than 0.05 eV and 0.015 eV with natural and enriched detectors, respectively. Besides, the GEM-I set up could advance the current best limits on the existence of neutralinos - as dark matter candidates - by three order of magnitudes, and at the same time would be able to identify unambiguously the dark matter signal by detection of its seasonal modulation.Comment: LaTeX, 20 pages, 4 figure

On possible lower bounds for the direct detection rate of SUSY Dark Matter

One can expect accessible lower bounds for dark matter detection rate due to restrictions on masses of the SUSY-partners. To explore this correlation one needs a new-generation large-mass detector. The absolute lower bound for detection rate can naturally be due to spin-dependent interaction. Aimed at detecting dark matter with sensitivity higher than $10^{-5}$ event/day/kg an experiment should have a non-zero-spin target. Perhaps, the best is to create a GENIUS-like detector with both Ge-73 (high spin) and Ge-76 nuclei.Comment: latex, 5 pages, 3 figures. Talk given at the III International Conference on Non-accelerator New Physics (NANP'01), Dubna, 19--23 June, 200

Double Beta Decay, Majorana Neutrinos, and Neutrino Mass

The theoretical and experimental issues relevant to neutrinoless double-beta decay are reviewed. The impact that a direct observation of this exotic process would have on elementary particle physics, nuclear physics, astrophysics and cosmology is profound. Now that neutrinos are known to have mass and experiments are becoming more sensitive, even the non-observation of neutrinoless double-beta decay will be useful. If the process is actually observed, we will immediately learn much about the neutrino. The status and discovery potential of proposed experiments are reviewed in this context, with significant emphasis on proposals favored by recent panel reviews. The importance of and challenges in the calculation of nuclear matrix elements that govern the decay are considered in detail. The increasing sensitivity of experiments and improvements in nuclear theory make the future exciting for this field at the interface of nuclear and particle physics.Comment: invited submission to Reviews of Modern Physics, higher resolution figures available upon request from authors, Version 2 has fixed typos and some changes after referee report

Gamow-Teller strength distributions in Xe isotopes

The energy distributions of the Gamow-Teller strength are studied for even-even Xe isotopes with mass numbers from 124 to 142. A self-consistent microscopic formalism is used to generate the single particle basis, using a deformed Skyrme Hartree-Fock mean field with pairing correlations in BCS approximation. The Gamow-Teller transitions are obtained within a quasiparticle random phase approximation (QRPA) approach using a residual spin-isospin interaction in the particle-hole and particle-particle channels. We then discuss the pairing BCS treatment and the determination of the ph and pp residual interaction coupling constants. We study the GT+ and GT- strength distributions for the equilibrium nuclear shapes, which are an essential information for studies of charge-exchange reactions and double-beta processes involving these isotopes.Comment: 15 pages, 5 figures. To appear in Phys Rev

Neutrinoless Double Beta Decay in Supersymmetric Seesaw model

Inspired by the recent HEIDELBERG-MOSCOW double beta decay experiment, we discuss the neutrinoless double beta decay in the supersymmetric seesaw model. Our numerical analysis indicates that we can naturally explain the data of the observed neutrinoless double beta decay, as well as that of the solar and atmospheric neutrino experiments with at least one Majorana-like sneutrino of middle energy scale in the model.Comment: latex, 25 pages, include 5 figures, final version in Phys. Rev.