Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines Results of a National Institutes of Health Working Group

Importance: Toxic epidermal necrolysis (TEN) and Stevens-Johnson Syndrome (SJS) are rare, acute, life-threatening dermatologic disorders involving the skin and mucous membranes. Research into these conditions is hampered by a lack of standardization of case reporting and data collection. Objective: To establish a standardized case report form to facilitate comparisons and maintain data quality based on an international panel of SJS/TEN experts who performed a Delphi consensus-building exercise. Evidence Review: The elements presented for committee scrutiny were adapted from previous case report forms and from PubMed literature searches of highly cited manuscripts pertaining to SJS/TEN. The expert opinions and experience of the members of the consensus group were included in the discussion. Findings: Overall, 21 out of 29 experts who were invited to participate in the online Delphi exercise agreed to participate. Surveys at each stage were administered via an online survery software tool. For the first 2 Delphi rounds, results were analyzed using the Interpercentile Range Adjusted for Symmetry method and statements that passed consensus formulated a new case report form. For the third Delphi round, the case report form was presented to the committee, who agreed that it was "appropriate and useful" for documenting cases of SJS/TEN, making it more reliable and valuable for future research endeavors. Conclusions and Relevance: With the consensus of international experts, a case report form for SJS/TEN has been created to help standardize the collection of patient information in future studies and the documentation of individual cases

7th Drug hypersensitivity meeting: part two

No abstract availabl

Effect of Hatha yoga training on rhinitis symptoms and cytokines in allergic rhinitis patients

Introduction: Allergic rhinitis is an inflammation of the nasal mucosa in response to allergens. There is evidence that yoga can improve personal health and has positive effects on immune function. However, the effects of Hatha yoga training on rhinitis symptoms and cytokines in patients with allergic rhinitis are still unclear. Objective: The purpose of this study was to investigate the effects of Hatha yoga training on rhinitis symptoms and cytokines in allergic rhinitis patients. Methods: Twenty-seven allergic rhinitis patients were randomized into 2 groups: a control group (CON; n = 14) and a yoga group (YOG; n = 13). The CON group continued with normal activities and the YOG group was required to complete a protocol of Hatha yoga training for 60 minutes per session, 3 times per week for 8 weeks. Physiological characteristics, allergic rhinitis symptoms, and cytokine secretions were comparatively analyzed before and after yoga training. Results: After 8 weeks, the YOG group had increased peak nasal inspiratory flow (PNIF) and exhibited significantly decreased rhinitis symptoms and nasal blood flow (NBF) compared to pre-test. Moreover, the YOG group had significantly higher nasal secretion of interleukin (IL)-2 than the CON group. Conclusion: The present findings demonstrated that 8 weeks of Hatha yoga training had beneficial effects in allergic rhinitis by improved clinical allergic rhinitis and cytokine profiles