ALMA CO J=6-5 observations of IRAS16293-2422: Shocks and entrainment

Observations of higher-excited transitions of abundant molecules such as CO are important for determining where energy in the form of shocks is fed back into the parental envelope of forming stars. The nearby prototypical and protobinary low-mass hot core, IRAS16293-2422 (I16293) is ideal for such a study. The source was targeted with ALMA for science verification purposes in band 9, which includes CO J=6-5 (E_up/k_B ~ 116 K), at an unprecedented spatial resolution (~0.2", 25 AU). I16293 itself is composed of two sources, A and B, with a projected distance of 5". CO J=6-5 emission is detected throughout the region, particularly in small, arcsecond-sized hotspots, where the outflow interacts with the envelope. The observations only recover a fraction of the emission in the line wings when compared to data from single-dish telescopes, with a higher fraction of emission recovered at higher velocities. The very high angular resolution of these new data reveal that a bow shock from source A coincides, in the plane of the sky, with the position of source B. Source B, on the other hand, does not show current outflow activity. In this region, outflow entrainment takes place over large spatial scales, >~ 100 AU, and in small discrete knots. This unique dataset shows that the combination of a high-temperature tracer (e.g., CO J=6-5) and very high angular resolution observations is crucial for interpreting the structure of the warm inner environment of low-mass protostars.Comment: Accepted for publication in A&A Letter

The observational impact of dust trapping in self-gravitating discs

We present a 3D semi-analytic model of self-gravitating discs, and include a prescription for dust trapping in the disc spiral arms. Using Monte-Carlo radiative transfer we produce synthetic ALMA observations of these discs. In doing so we demonstrate that our model is capable of producing observational predictions, and able to model real image data of potentially self-gravitating discs. For a disc to generate spiral structure that would be observable with ALMA requires that the disc's dust mass budget is dominated by millimetre and centimetre-sized grains. Discs in which grains have grown to the grain fragmentation threshold may satisfy this criterion, thus we predict that signatures of gravitational instability may be detectable in discs of lower mass than has previously been suggested. For example, we find that discs with disc-to-star mass ratios as low as $0.10$ are capable of driving observable spiral arms. Substructure becomes challenging to detect in discs where no grain growth has occurred or in which grain growth has proceeded well beyond the grain fragmentation threshold. We demonstrate how we can use our model to retrieve information about dust trapping and grain growth through multi-wavelength observations of discs, and using estimates of the opacity spectral index. Applying our disc model to the Elias 27, WaOph 6 and IM Lup systems we find gravitational instability to be a plausible explanation for the observed substructure in all 3 discs, if sufficient grain growth has indeed occurred.Comment: 19 pages, 21 figures, accepted for publication in MNRA

An optical parsec-scale jet from a massive young star in the Large Magellanic Cloud

Highly collimated parsec-scale jets, generally linked to the presence of an accretion disk, are a commonly observed phenomenon from revealed low-mass young stellar objects. In the past two decades, only a very few of these objects have been directly (or indirectly) observed towards high-mass (M > 8 M$_{\odot}$) young stellar objects, adding to the growing evidence that disk-mediated accretion is a phenomenon also occurring in high-mass stars, the formation mechanism of which is still poorly understood. Of the observed jets from massive young stars, none is in the optical regime (due to these being typically highly obscured by their native material), and none are found outside of the Milky Way. Here, we report the detection of HH 1177, the first extragalactic optical ionized jet originating from a massive young stellar object located in the Large Magellanic Cloud. The jet is highly collimated over the entire measured extent of at least 10 pc, and has a bipolar geometry. The presence of a jet indicates ongoing, disk-mediated accretion, and together with the high degree of collimation, this system is therefore likely to be an up-scaled version of low-mass star formation. We conclude that the physics governing jet launching and collimation is independent of stellar mass.Comment: 9 pages, 5 figures, 2 table

Vortex pinning by natural defects in thin films of YBa2Cu3O7−δ

Although vortex pinning in laser-ablated YBa2Cu3O7−δ films on (100) SrTiO3 is dominated by threading dislocations, many other natural pinning sites are present. To identify the contribution from twin planes, surface corrugations and point defects, we manipulate the relative densities of all defects by post-annealing films with various as-grown dislocation densities, ndisl. While a universal magnetic field B dependence of the transport current density js(B, T) is observed (independently of ndisl, temperature T and the annealing treatment), the defect structure changes considerably. Correlating the microstructure to js(B, T), it becomes clear that surface roughness, twins and point defects are not important at low magnetic fields compared to linear defect pinning. Transmission electron microscopy indicates that threading dislocations are not part of grain boundaries nor are they related to the twin domain structure. We conclude that js(B, T) is essentially determined by pinning along threading dislocations, naturally induced during the growth process. Even in high magnetic fields, where the vortex density outnumbers ndisl, it appears that linear defects stabilize the vortex lattice by means of the vortex–vortex interaction.

Carina's Pillars of Destruction: the view from ALMA

Forming high-mass stars have a significant effect on their natal environment. Their feedback pathways, including winds, outflows, and ionising radiation, shape the evolution of their surroundings which impacts the formation of the next generation of stars. They create or reveal dense pillars of gas and dust towards the edges of the cavities they clear. They are modelled in feedback simulations, and the sizes and shapes of the pillars produced are consistent with those observed. However, these models predict measurably different kinematics which provides testable discriminants. Here we present the first ALMA Compact Array (ACA) survey of 13 pillars in Carina, observed in $^{12}$CO, $^{13}$CO and C$^{18}$O J=2-1, and the 230 GHz continuum. The pillars in this survey were chosen to cover a wide range in properties relating to the amount and direction of incident radiation, proximity to nearby irradiating clusters and cloud rims, and whether they are detached from the cloud. With these data, we are able to discriminate between models. We generally find pillar velocity dispersions of $<$ 1 km s$^{-1}$ and that the outer few layers of molecular emission in these pillars show no significant offsets from each other, suggesting little bulk internal motions within the pillars. There are instances where the pillars are offset in velocity from their parental cloud rim, and some with no offset, hinting at a stochastic development of these motions.Comment: 24 Pages, 19 figures. Accepted to MNRA

CO in HI Self-Absorbed Clouds in Perseus

We have observed 12CO J = 2-1 and J = 1-0, and 13CO J = 1-0 emission in two regions of HI Self-Absorption (HISA) in Perseus: a small, isolated HISA feature called the globule and a more extended HISA cloud called the complex. Using both Large Velocity Gradient and Monte Carlo radiative transfer codes we found that, in the globule, N(12CO) < 6.0x10^15 cm-2 which, using PDR models, implies that N(H_2) < 9.9x10^20 cm-2. In the complex we found that the H_2 column densities ranged from 1.2 - 2.2 x 10^21 cm-2. By comparing the HISA and CO observations we are able to constrain the physical conditions and atomic gas fraction (f). In the globule, 8 K < T_spin < 22 K and 0.02 < f < 0.2 depending on whether the (unknown) gas density is 10^2, 10^3, or 10^4 cm-3. In the complex, 12 K < T_spin < 24 K, 0.02 < f < 0.05, and we were also able to constrain the gas density (100 < n < 1200 cm-3). These results imply that the gas in the HISA clouds is colder and denser than that usually associated with the atomic ISM and, indeed, is similar to that seen in molecular clouds. The small atomic gas fractions also imply that there is a significant molecular component in these HISA clouds, even when little or no 12CO is detected. The level of 12CO detected and the visual extinction due to dust is consistent with the idea that these HISA clouds are undergoing a transition from the atomic to molecular phase.Comment: 25 pages, 5 figures, tentatively scheduled for the ApJ 1 October 2005, v 631, 2 issu

Reanalysing genomic data by normalized coverage values uncovers CNVs in bone marrow failure gene panels

Inherited bone marrow failure syndromes (IBMFSs) are genetically heterogeneous disorders with cytopenia. Many IBMFSs also feature physical malformations and an increased risk of cancer. Point mutations can be identified in about half of patients. Copy number variation (CNVs) have been reported; however, the frequency and spectrum of CNVs are unknown. Unfortunately, current genome-wide methods have major limitations since they may miss small CNVs or may have low sensitivity due to low read depths. Herein, we aimed to determine whether reanalysis of NGS panel data by normalized coverage value could identify CNVs and characterize them. To address this aim, DNA from IBMFS patients was analyzed by a NGS panel assay of known IBMFS genes. After analysis for point mutations, heterozygous and homozygous CNVs were searched by normalized read coverage ratios and specific thresholds. Of the 258 tested patients, 91 were found to have pathogenic point variants. NGS sample data from 165 patients without pathogenic point mutations were re-analyzed for CNVs; 10 patients were found to have deletions. Diamond Blackfan anemia genes most commonly exhibited heterozygous deletions, and included RPS19, RPL11, and RPL5. A diagnosis of GATA2-related disorder was made in a patient with myelodysplastic syndrome who was found to have a heterozygous GATA2 deletion. Importantly, homozygous FANCA deletion were detected in a patient who could not be previously assigned a specific syndromic diagnosis. Lastly, we identified compound heterozygousity for deletions and pathogenic point variants in RBM8A and PARN genes. All deletions were validated by orthogonal methods. We conclude that careful analysis of normalized coverage values can detect CNVs in NGS panels and should be considered as a standard practice prior to do further investigations