Leather Shaving – A New Approach for Understanding the Shaving Process

Content: The shaving process is one of the most important steps in leather production. However, the underlying principles and mechanisms are not yet fully understood. Generally, the successful performance of the shaving process is based on long-time experience, and the tanneries rather optimize the preceding process steps than change the shaving parameters. In a current research project the research partners (Heusch GmbH, TU Dresden and FILK gGmbH) have united their expertise in order to understand the interaction between the shaving blade and the semi-finished leather (wet-blue or wet-white). The objective of the project is to gain more insight into the physics of shaving and to create a background of knowledge, which will be the technical base for developing novel and more effective shaving blades. Heusch presents the advantages of a novel serrated shaving blade. In comparison with the standard design an serrated blade yields higher shaving accuracy and uniform thickness of the hides. Stretching forces along the dorsal line of the hides are reduced, which avoids structural damage. Marginal hide regions are less frayed, thus increasing the usable surface area. The small size and compact form of the shavings are advantageous for recycling and disposal. Exploiting these advantages combined with an optimized grinding process, the user can increase the lifetime of the serrated blades. Based on these experiences there is an urgent need to thoroughly understand the physical cutting processes which take place during the shaving step. In the current research project an experimental test station is designed which is intended to simulate the shaving process in a simplified setting as a cutting procedure of a blade into a leather surface. This test station will enable the variation of material, geometry and configuration of the blade as well as the measurement of forces emerging during cutting at the blade and the leather surface, which emerge during cutting. The registered data shall provide information on the question, how the cutting forces depend on technological parameters, like blade material, geometry, configuration, cutting speed, leather moisture or tanning method. Based on the knowledge of these relationships novel, even more effective shaving blades can be developed. In a second approach the cutting process of a single leather fibre will be simulated virtually on a microscale level. The goal is the understanding of the interaction of a moving metal blade with a flexible, unilaterally fixed leather fibre. The simulation is supposed to yield data on cutting speed and fibre behaviour under conditions which are experimentally difficult to access. Take-Away: The physical basics of the shaving process are not yet fully understood. The presented research project aims at the understanding of the interaction between shaving blade and leather fibres during the shaving process. The approach in the project is to model the cutting procedure in a simplified experimental test station and in a computational simulation model

Institutions, policies, and arguments:context and strategy in EU policy framing

Studies of framing in the EU political system are still a rarity and they suffer from a lack of systematic empirical analysis. Addressing this gap, we ask if institutional and policy contexts intertwined with the strategic side of framing can explain the number and types of frames employed by different stakeholders. We use a computer-assisted manual content analysis and develop a fourfold typology of frames to study the frames that were prevalent in the debates on four EU policy proposals within financial market regulation and environmental policy at the EU level and in Germany, Sweden, the Netherlands and the United Kingdom. The main empirical finding is that both contexts and strategies exert a significant impact on the number and types of frames in EU policy debates. In conceptual terms, the article contributes to developing more fine-grained tools for studying frames and their underlying dimensions

Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome

Vaccine development is essential for pandemic preparedness. We previously conducted a Phase 1 clinical trial of the vector vaccine candidate MVA-MERS-S against the Middle East respiratory syndrome coronavirus (MERS-CoV), expressing its full spike glycoprotein (MERS-CoV-S), as a homologous two-dose regimen (Days 0 and 28). Here, we evaluate a third vaccination with MVA-MERS-S in a subgroup of trial participants one year after primary immunization. A booster vaccination with MVA-MERS-S is safe and well-tolerated. Both binding and neutralizing anti-MERS-CoV antibody titers increase substantially in all participants and exceed maximum titers observed after primary immunization more than 10-fold. We identify four immunogenic IgG epitopes, located in the receptor-binding domain (RBD, n=1) and the S2 subunit (n=3) of MERS-CoV-S. The level of baseline anti-human coronavirus antibody titers does not impact the generation of anti-MERS-CoV antibody responses. Our data support the rationale of a booster vaccination with MVA-MERS-S and encourage further investigation in larger trials

Opinion on 'Responsible Dual Use' Political, Security, Intelligence and Military Research of Concern in Neuroscience and Neurotechnology

Current and newly emerging insights and technologies arising from research in brain sciences increase capabilities to access, assess and affect thought, emotion and behaviour. While much of this research and development is directed towards clinical use, it also has applications in other settings, notably in the political, security, intelligence and military (PSIM) domains. This is often referred to in terms of ‘Dual Use’. Many of these potential uses raise important social and ethical questions which demand the attention of all those involved in the research, administration, management and regulation of neuroscience research and related technological developments, including those in information and communication technologies (ICT) and robotics. In this Opinion, we suggest that we can increase our ability to identify which programmes and projects of research, development and innovation are ‘of concern’ by applying the principles of Responsible Research and Innovation (RRI) to the concept of ‘dual use’ and distinguishing between ‘responsible’ and ‘irresponsible’ systems of research and technological development. We therefore use the term ‘dual use research of concern’ (DURC) to refer to neuroscience research and technological innovations, and brain inspired developments in information and communication technologies, for use in the political, security, intelligence and military domains, which are either directly of concern because of their potential for use in ways that threaten the peace, health, safety, security and well-being of citizens, or are undertaken without responsible regard to such potential uses. To ensure ongoing attention to these issues, the Opinion proposes recommendations for the Human Brain Project, the European Union and the wider neuroscience and ICT community

Interest representation in the EU: an open and structured dialogue?

Since 1992, the European Commission has sought to build ‘An Open and Structured Dialogue’ with interest groups, and since 2001 a broader ‘Dialogue with Civil Society’. A core feature of this dialogue involves instruments of transparency, and pluralism, with funding to ensure the presence of a wide range of voices. Consultation procedures provide for a ‘marketplace of ideas’ which simulate political competition and contestation, with a ‘voice but not a vote’, and which are supposed to provide for answerability by the European Commission for its policy choices. The European Commission also selects its allies to support its regulatory proposals, with NGOs frequent allies as well as firms and business sectors supporting higher standards. The EU’s fragmented decision-making system helps to provide a naturally pluralist environment, although some recent research suggests that NGOs are more likely to be successful in securing their policy goals than business organizations. NGOs work mostly in coalitions, with the size of coalition a factor in lobbying success. The saliency of issues is another substantial feature of variation in lobbying success and where NGOs can raise the contention of issues they can bring wider participation in EU issues

Policy ideas through the prism of knowledge regimes and framing

Policymakers are often confronted with problems that involve ambiguity and uncertainty (Zahariadis, 2003). In order to make sense of such problems and to identify possible solutions, they are on the lookout for policy ideas

Boolean Dynamics with Random Couplings

This paper reviews a class of generic dissipative dynamical systems called N-K models. In these models, the dynamics of N elements, defined as Boolean variables, develop step by step, clocked by a discrete time variable. Each of the N Boolean elements at a given time is given a value which depends upon K elements in the previous time step. We review the work of many authors on the behavior of the models, looking particularly at the structure and lengths of their cycles, the sizes of their basins of attraction, and the flow of information through the systems. In the limit of infinite N, there is a phase transition between a chaotic and an ordered phase, with a critical phase in between. We argue that the behavior of this system depends significantly on the topology of the network connections. If the elements are placed upon a lattice with dimension d, the system shows correlations related to the standard percolation or directed percolation phase transition on such a lattice. On the other hand, a very different behavior is seen in the Kauffman net in which all spins are equally likely to be coupled to a given spin. In this situation, coupling loops are mostly suppressed, and the behavior of the system is much more like that of a mean field theory. We also describe possible applications of the models to, for example, genetic networks, cell differentiation, evolution, democracy in social systems and neural networks.Comment: 69 pages, 16 figures, Submitted to Springer Applied Mathematical Sciences Serie