Developing stem cell-based therapeutic strategies in orthopaedic surgery

open5siEDITORIAL - Developing Stem Cell-Based Therapeutic Strategies in Orthopaedic SurgeryopenAtesok, Kivanc; Ochi, Mitsuo; Baldini, Nicola; Schemitsch, Emil; Liebergall, MeirAtesok, Kivanc; Ochi, Mitsuo; Baldini, Nicola; Schemitsch, Emil; Liebergall, Mei

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Current Strategies in Prevention of Postoperative Infections in Spine Surgery.

Study Design: Narrative review. Objectives: Postoperative surgical site infections (SSIs) are among the most common acute complications in spine surgery and have a devastating impact on outcomes. They can lead to increased morbidity and mortality as well as greater economic burden. Hence, preventive strategies to reduce the rate of SSIs after spine surgery have become vitally important. The purpose of this article was to summarize and critically analyze the available evidence related to current strategies in the prevention of SSIs after spine surgery. Methods: A literature search utilizing Medline database was performed. Relevant studies from all the evidence levels have been included. Recommendations to decrease the risk of SSIs have been provided based on the results from studies with the highest level of evidence. Results: SSI prevention occurs at each phase of care including the preoperative, intraoperative, and postoperative periods. Meticulous patient selection, tight glycemic control in diabetics, smoking cessation, and screening/eradication of Conclusions: Although preventive strategies are already in use alone or in combination, further high-level research is required to prove their efficacy in reducing the rate of SSIs in spine surgery before evidence-based standard infection prophylaxis guidelines can be built

The Izmir City and Natural Hazard Risks

Turkey has many geological disadvantages such as sitting on top of active tectonic plate boundaries, and why having avalanche, flood, and landslide and drought prone areas. However, this natural structure is inevitable; the only way to survive in such a harsh geography is to be aware of importance of these natural events and to take political and physical measures. Natural hazards are generally forgotten shortly after a while. Many projects that are planned to mitigate future hazards are suspended soon after natural hazards happened. Instead of taking pre- disaster measures and precautions, only emergency measures for recovery and post- disaster aid to the victims of a calamity are applied. Izmir which is the third biggest city in Turkey survived as a big city throughout its history of 5000 years and has been frequently renovated under geopolitical and geological influences. Izmir has been greatly affected by some disasters such as earthquakes, fires, epidemics and etc. Thus many edifices that would reflect historical background of the city did not survive until today and present remains are generally few and known only by experts and the neighboring people (Towards Agenda 21 in Izmir, 1998). Population increases and its development pressures on rural areas are inevitable problems for Izmir. Urban housing supply could not meet the demand, the housing policies could not be integrated with that of urban land and the housing subsidies could not help to serve low-income groups. Natural environmental features of Izmir increase its natural hazard risks. Izmir has sloppy topography that surrounds the city shape. Further more, soil geology is unsuitable for to settle down in built up area. On the other hand natural hazard risks increase because of the spread of the illegal urban settlements and because of the feeble building types. The major aim of this research is to bring up the magnitude of natural hazard risks in Izmir built-up zone, not being taken into consideration adequately. Because the dimensions of the peril are not taken seriously enough, the natural hazard risks, which are commonly well known, are not considered important or they are being forgotten after some time passes. Within this research, the magnitude of natural hazard risks for Izmir is being presented in the scope of concrete and local researches over Izmir risky areas.

Producción de lipasa extracelular por Enterococcus faecium E68 en residuos de aceite de oliva como sustrato

With green technologies, the damages caused by agro-technological wastes to the environment are eliminated. In our study, it was aimed both to prevent the harm of olive oil waste to the environment and to produce lipase enzyme, which is an important biotechnological product.. E. faecium E68 obtained from milk and dairy products was used in the production of lipase enzyme. E. faecium E68 was developed in lipase production medium containing 10% olive waste, pH6.5, at 37oC with 120 rpm agitation for 48 hours. The effect of temperature, pH metal ion, surfactant and NaCl was also determined. The molecular weight of the partially purified extracellular lipase enzyme was estimated to be around 19-20 kDa  by SDS-PAGE.   The optimum temperature was 45°C, while the enzyme exhibited appreciable thermostability retaining of activity at 55°C for 48h. The lipase was most active in the pH range of 3-11 with an optimum activity at pH 10. 1mM, Ca 2+, Mn2+, Cu2+, Ni2+, Zn2+, Mg2+ and K+ ions modulated the activity of the enzyme but inhibited by Hg2+, SDS and Triton X-100. The enzyme is halophilic and 25% NaCl salt increased the activity. Olive oil waste may be the preferred substrate for lipase production.Con las tecnologías verdes se eliminan los daños que ocasionan los desechos agrotecnológicos al medio ambiente. En nuestro estudio, el objetivo era prevenir el daño de los residuos de aceite de oliva al medio ambiente y producir la enzima lipasa, que es un producto biotecnológico importante. E. faecium E68 obtenido de leche y productos lácteos se utilizó en la producción de la enzima lipasa. E. faeciumE68 se desarrolló en medio de producción de lipasa con un 10% de orujo de aceituna, pH 6,5, a 37 oC con agitación a 120 rpm durante 48 h. También se determinó el efecto de la temperatura, el pH del ion metálico, el surfactante y el NaCl. El peso molecular de la enzima lipasa extracelular parcialmente purificada se estimó en alrededor de 19-20 kDa mediante SDS-PAGE. La temperatura óptima fue de 45 °C, mientras que la enzima exhibió una termoestabilidad apreciable reteniendo la actividad a 55°C durante 48 h. La actividad óptima de la lipasa fue a pH10. Los iones 1mM, Ca 2+, Mn2+, Cu2+, Ni2+, Zn2+, Mg2+ y K+ modularon la actividad de la enzima pero fueron inhibidos por Hg2+, SDS y Triton X-100. La enzima es halófila y la sal de NaCl al 25% aumentó la actividad

Agricultural by-products for phosphorous removal and recovery from water and wastewater: A green technology

© 2016 American Society of Civil Engineers. Phosphorus (P) is a critical nutrient for plant growth. The excessive amount of P in aquatic medium may originate from natural sources and/or artificial sources. This chapter discusses P removal/recovery from wastewater due to surface water quality deterioration and P rock reserves depletion. It focuses on both fundamental and applied aspects of this practice using agricultural waste based biosorbents (AWBs). Understanding the operation principles is expected to enable the application of AWBs in the future. Because of increasing concerns relevant to water quality deterioration and depletion of global P rock reserves, P removal/recovery recently has become a matter of interest. Even though various technologies are presently available, adsorption seems to have advantages when used for P recovery. Although AWBs in both natural and modified forms can be used for P removal, the low P uptake capacity of raw AWBs hinders their widespread application

Cutaneous tuberculosis (scrofuloderma) in a five year-old boy: Case report

Cutaneous tuberculosis (CTB) is a rare form of extrapulmonary TB in our region. The incidence of CTB seems to be increasing in some countries. CTB continues to be one of the most elusive and difficult diagnoses to make for dermatologists practicing in developing countries. We report the case of a five-year-old boy with an infected discharging ulcer on his face referred to our hospital in Gorgan, north of Iran. After physical, pathological and radiological examination, the diagnosis of CTB was confirmed. The condition improved after standard antitubercular regimen

Multiuser MIMO-OFDM Systems using Subcarrier Hopping

Recently space division multiple access (SDMA) assisted multiple-input–multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) systems invoking multiuser detection (MUD) techniques have attracted substantial research interest, which is capable of exploiting both transmitter multiplexing gain and receiver diversity gain. A new scheme referred to here as slowsubcarrierhopping (SSCH) assisted multiuser SDMA-OFDM, is proposed. It is shown that, with the aid of the so-called uniform SSCH (USSCH) pattern, the multiuser interference (MUI) experienced by the high-throughput SDMA-OFDM system can be effectively suppressed, resulting in a significant performance improvement. In the investigations conducted, the proposed USSCH-aided SDMA-OFDM system was capable of outperforming a range of SDMA-OFDM systems considered, including the conventional SDMA-OFDM system dispensing with the employment of frequency-hopping techniques. For example, at an Eb/N0 value of 12 dB, the proposed USSCH/SDMA-OFDM system reduced the bit error ratio (BER) by about three orders of magnitude, in comparison to the conventional SDMA-OFDM system, while maintaining a similar computational complexity