Non-parametric Cosmology with Cosmic Shear

We present a method to measure the growth of structure and the background geometry of the Universe -- with no a priori assumption about the underlying cosmological model. Using Canada-France-Hawaii Lensing Survey (CFHTLenS) shear data we simultaneously reconstruct the lensing amplitude, the linear intrinsic alignment amplitude, the redshift evolving matter power spectrum, P(k,z), and the co-moving distance, r(z). We find that lensing predominately constrains a single global power spectrum amplitude and several co-moving distance bins. Our approach can localise precise scales and redshifts where Lambda-Cold Dark Matter (LCDM) fails -- if any. We find that below z = 0.4, the measured co-moving distance r (z) is higher than that expected from the Planck LCDM cosmology by ~1.5 sigma, while at higher redshifts, our reconstruction is fully consistent. To validate our reconstruction, we compare LCDM parameter constraints from the standard cosmic shear likelihood analysis to those found by fitting to the non-parametric information and we find good agreement.Comment: 13 pages. Matches PRD accepted versio

FEATURE EXTRACTION AND MATCHING OF PALMPRINTS USING LEVEL I DETAIL

A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyCurrent Automatic Palmprint Identification Systems (APIS) closely follow the matching philosophy of Automatic Fingerprint Identification Systems (AFIS), in that they exclusively use a small subset of Level II palmar detail, when matching a latent to an exemplar palm print. However, due the increased size and the significantly more complex structure of the palm, it has long been recognised that there is much detail that remains underutilised. Forensic examiners routinely use this additional information when manually matching latents. The thesis develops novel automatic feature extraction and matching methods which exploit the underutilised Level I detail contained in the friction ridge flow. When applied to a data base of exemplars, the approach creates a ranked list of matches. It is shown that the matching success rate varied with latent size. For latents of diameter 38mm, 91:1% were ranked first and 95:6% of the matches were contained within the ranked top 10. The thesis presents improved orientation field extraction methods which are optimised for friction ridge flow and novel enhancement techniques, based upon the novel use of local circular statistics on palmar orientation fields. In combination, these techniques are shown to provide a more accurate orientation estimate than previous work. The novel feature extraction stages exploit the level sets of higher order local circular statistics, which naturally segment the palm into homogeneous regions representing Level I detail. These homogeneous regions, characterised by their spatial and circular features, are used to form a novel compact tree-like hierarchical representation of the Level I detail. Matching between the latent and an exemplar is performed between their respective tree-like hierarchical structures. The methods developed within the thesis are complementary to current APIS techniques

Preparing for the Cosmic Shear Data Flood: Optimal Data Extraction and Simulation Requirements for Stage IV Dark Energy Experiments

Upcoming photometric lensing surveys will considerably tighten constraints on the neutrino mass and the dark energy equation of state. Nevertheless it remains an open question of how to optimally extract the information and how well the matter power spectrum must be known to obtain unbiased cosmological parameter estimates. By performing a Principal Component Analysis (PCA), we quantify the sensitivity of 3D cosmic shear and tomography with different binning strategies to different regions of the lensing kernel and matter power spectrum, and hence the background geometry and growth of structure in the Universe. We find that a large number of equally spaced tomographic bins in redshift can extract nearly all the cosmological information without the additional computational expense of 3D cosmic shear. Meanwhile a large fraction of the information comes from small poorly understood scales in the matter power spectrum, that can lead to biases on measurements of cosmological parameters. In light of this, we define and compute a cosmology-independent measure of the bias due to imperfect knowledge of the power spectrum. For a Euclid-like survey, we find that the power spectrum must be known to an accuracy of less than 1% on scales with k = 7 h /Mpc This requirement is not absolute since the bias depends on the magnitude of modelling errors, where they occur in k-z space, and the correlation between them, all of which are specific to any particular model. We therefore compute the bias in several of the most likely modelling scenarios and introduce a general formalism and public code, RequiSim, to compute the expected bias from any non-linear model.Comment: 17 pages, 13 figures. Accepted and published in PR

Fibrin independent proinflammatory effects of tissuefactor in experimental crescentic glomerulonephritis

Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis.BackgroundTissue factor initiated glomerular fibrin deposition is an important mediator of injury in crescentic glomerulonephritis. Recent data have suggested noncoagulant roles for tissue factor in inflammation.MethodsTo test the hypothesis that in addition to its effects in initiating coagulation, tissue factor has proinflammatory effects in glomerulonephritis, rabbits given crescentic anti-glomerular basement membrane (GBM) antibody–induced glomerulonephritis were defibrinogenated with ancrod. One group of defibrinogenated rabbits was also given anti-tissue factor antibodies. Comparisons were made between these groups, as well as a third group that was neither defibrinogenated with ancrod nor given anti-tissue factor antibodies.ResultsDefibrinogenation alone abolished glomerular fibrin deposition, reduced crescent formation, and limited renal impairment (ancrod-treated, serum creatinine 274 ± 37 μmol/L; untreated 415 ± 51 μmol/L; P < 0.01). Tissue factor inhibition in defibrinogenated rabbits resulted in further protection of renal function (creatinine 140 ± 19 μmol/L, P < 0.01) and reduced proteinuria (0.4 ± 0.2g/day, untreated 2.6 ± 0.4 g/day, P <0.01), which was significantly increased by defibrinogenation alone (ancrod-treated, 5.6 ± 1.2 g/day). Anti-tissue factor antibodies (but not defibrinogenation alone) attenuated glomerular T-cell and macrophage recruitment, and major histocompatibility complex (MHC) class II expression.ConclusionThese results demonstrate important proinflammatory effects of tissue factor in crescentic glomerulonephritis that are fibrin independent and provide in vivo evidence for tissue factor's proinflammatory effects on MHC class II expression and leukocyte accumulation

Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice

Interleukin-4 deficiency enhances Th1 responses and crescentic glomerulonephritis in mice. Evidence suggests that crescentic glomerulonephritis (GN) is due to T helper cell 1 (Th1) directed delayed-type hypersensitivity (DTH)-like injury. As endogenous interleukin (IL)-4, (the pivotal cytokine in Th2 responses) may attenuate Th1 responses in this disease, we compared the development of crescentic GN, induced by a planted antigen, in mice genetically deficient in IL-4 (IL-4−/−) with disease in normal mice (IL-4+/+). IL-4−/− mice developed more severe GN with increased renal impairment (CCr 35 ± 7 μl/min vs. 133 ± 14 μl/min, P < 0.002) and crescent formation (55.7 ± 8.4% vs. 4.9 ± 1.2%, P < 0.002). This was associated with increased glomerular fibrin deposition, glomerular CD4+ T cell infiltration and macrophage recruitment. Systemically, IL-4−/− mice showed an increased antigen specific Th1 response indicated by increased skin DTH, and increased IgG3 and IgG2b. Decreased IgG1 levels indicated a reduced Th2 response. These results demonstrate a protective role for endogenous IL-4 in crescentic GN. They show that IL-4 deficiency promotes crescentic glomerular injury and amplifies local and systemic Th1 responses. They support the hypothesis that crescent formation results from Th1 immune responses to antigens in the glomerulus

Rainbow cosmic shear: Optimization of tomographic bins

In this paper, we address the problem of finding optimal cosmic shear tomographic bins. We generalize the definition of a cosmic shear tomographic bin to be a set of commonly labeled voxels in photometric color space; rather than bins defined directly in redshift. We explore this approach by using a self-organizing map to define the multidimensional color space, and a we define a “label space” of connected regions on the self-organizing map using overlapping elliptical disks. This allows us to then find optimal labeling schemes by searching the label space. We use a metric that is the signal-to-noise ratio of a dark energy equation of state measurement, and in this case we find that for up to five tomographic bins the optimal color-space labeling is an approximation of an equally spaced binning in redshift; that is in all cases the best configuration. We also show that such a redefinition is more robust to photometric redshift outliers than a standard tomographic bin selection

Susceptibility of Pigs and Chickens to SARS Coronavirus

An outbreak of severe acute respiratory syndrome (SARS) in humans, associated with a new coronavirus, was reported in Southeast Asia, Europe, and North America in early 2003. To address speculations that the virus originated in domesticated animals, or that domestic species were susceptible to the virus, we inoculated 6-week-old pigs and chickens intravenously, intranasally, ocularly, and orally with 106 PFU of SARS-associated coronavirus (SARS-CoV). Clinical signs did not develop in any animal, nor were gross pathologic changes evident on postmortem examinations. Attempts at virus isolation were unsuccessful; however, viral RNA was detected by reverse transcriptase-polymerase chain reaction in blood of both species during the first week after inoculation, and in chicken organs at 2 weeks after inoculation. Virus-neutralizing antibodies developed in the pigs. Our results indicate that these animals do not play a role as amplifying hosts for SARS-CoV