Cooperative awareness using roadside unit networks in mixed traffic

International audienceVehicle-to-vehicle (V2V) messaging is an indispensable component of connected autonomous vehicle systems. Although V2V standards have been specified by the European Union, United States, and Japan, the deployment phase represents mixed traffic in which connected and legacy vehicles co-exist. To enhance cooperative awareness in this mixed traffic, we assessed the special roadside unit that we developed in our previous work that generates required V2V messages on behalf of sensed target vehicles. In this paper, we extend our earlier work to propose a system called Grid Proxy Cooperative Awareness Message to broaden the cooperative awareness message dissemination area by connecting infrastructure using high-speed roadside networks. To minimize delay in message delivery, we designed the proposed system to use edge computing. The proposed scheme delivers cooperative messages to a wider area with a low delay and a high packet delivery ratio by prioritizing packets by their respective safety contributions. Our simulation results indicate that the proposed scheme efficiently delivers messages in heavy road traffic conditions modeled on real maps of Tokyo and Paris

Stroke Status Evoked Adhesion Molecule Genetic Alterations in Astrocytes Isolated from Stroke-Prone Spontaneously Hypertensive Rats and the Apigenin Inhibition of Their Expression

We examined the possibility that the expression of adhesion molecules is regulated differently in cultured astrocytes from stroke-prone spontaneously hypertensive rats (SHRSP/IZM) rats than in those from Wistar Kyoto rats (WKY/IZM) by tumor necrosis factor-alpha (TNF-α) or hypoxia and reoxygenation (H/R) and the inhibitory effects of apigenin. It was found that the expression of vascular cell adhesion molecule-1 (VCAM-1) by TNF-α in astrocytes isolated from SHRSP/IZM was increased compared with that in WKY/IZM. The expression of monocyte chemotactic protein-1 (MCP-1) mRNA induced by H/R in SHRSP/IZM astrocytes was increased compared with that in normal oxygen concentrations. Apigenin strongly attenuated TNF-α-induced VCAM-1 mRNA and protein expression and suppressed the adhesion of U937 cells and SHRSP/IZM astrocytes. These results suggest that the expression levels of adhesion molecules during H/R affect disease outcome and can drive SHRSP/IZM to stroke. It is suggested that apigenin regulates adhesion molecule expression in reactive astrocytes during ischemia

Statistical Analysis of Lessons Learned from University Satellite Projects in Japan

University Space Engineering Consortium (UNISEC) is a non-profitable organization established in 2003 with the purpose of supporting the “ realization of practical space engineering activities, ” and providing support to universities and research institutions in Japan. UNISEC has accumulated practical experiences and achievements from more than 80 micro- and nano-satellite projects of the corporate partners, which also includes the two world-first-CubeSats launched in 2003. Following the recent drastic increase of academic and commercial space development and utilization activities all over the world, UNISEC has recently conducted a survey on the lessons learned of safety and mission assurance of these satellites partly as a contract from JAXA, to distill the best practices to ensure the mission success of the satellites. The survey contains replies from more than 15 faculty members and researchers of 10 universities or institutions or colleges with information about 36 satellite projects, 208 individual success and failure cases. In this research, we analyzed questionnaires of lessons learned from each satellite project statistically by sampling specific terms and counting frequency. The questionnaire contains technical topics and project management topics (including human factors, team/organization factors, schedule factors) for the analysis of individual subjects of success or failure. The examples are categorized into the following: Accomplishments or failures of the mission on orbit, Demonstrations or troubles on the bus functions, and Supplemental products (design/test process, educational effects)

Boundary operators and touching of loops in 2d gravity

We investigate the correlators in unitary minimal conformal models coupled to two-dimensional gravity from the two-matrix model. We show that simple fusion rules for all of the scaling operators exist. We demonstrate the role played by the boundary operators and discuss its connection to how loops touch each other.Comment: 19 pages, Latex, 3 Postscript figure

Anomalous magnetization process in frustrated spin ladders

We study, at T=0, the anomalies in the magnetization curve of the S=1 two-leg ladder with frustrated interactions. We focus mainly on the existence of the M=\Ms/2 plateau, where \Ms is the saturation magnetization. We use analytical methods (degenerate perturbation theory and non-Abelian bosonization) as well as numerical methods (level spectroscopy and density matrix renormalization group), which lead to the consistent conclusion with each other. We also touch on the M=\Ms/4 and M=(3/4)\Ms plateaux and cusps.Comment: 4 pages, 7 figures (embedded), Conference paper (Highly Frustrated Magnetism 2003, 26-30th August 2003, Grenoble, France

Quantum Paraelectric States in SrTiO3 and KTaO3: Barrett Model, Vendik Model, and Quantum Criticality

The dielectric constants of the quantum paraelectrics SrTiO3 and KTaO3 are measured between 4 and 325 K. Their temperature dependences are analyzed on the basis of the Barrett and Vendik models. The former model deals with a ferroelectric optical mode coupled with other optical modes, whereas the latter deals with the mode coupled with acoustic modes. In addition, the latter contains a measure of the density of defects and inhomogeneity. The dielectric constants at low temperatures can be accurately described using Vendik’s formula; however, they cannot be accurately described using Barrett’s formula, even after the introduction of a measure of the density of defects and inhomogeneity. A critical quantum paraelectric region has been introduced recently between a classical region and a quantum paraelectric one. We point out that the critical region is where a low-temperature approximation is well realized for the model with the coupling between the ferroelectric and acoustic modes.Embargo Period 12 months, An ex post facto report is necessar

Potential use of lenvatinib for patients with unresectable hepatocellular carcinoma including after treatment with sorafenib : Real-world evidence and in vitro assessment via protein phosphorylation array

The efficacy and safety of lenvatinib (LEN) as a second/third-line treatment for unresectable hepatocellular carcinoma (HCC) after sorafenib (SOR) therapy remains unknown. We evaluated the outcomes of second/third-line LEN treatment, investigated the sensitivity of a SOR-resistant HCC cell line (PLC/PRF5-R2) to LEN, and assessed their signal transduction pathways by protein array analysis. We retrospectively enrolled 57 patients with unresectable HCC. Fifty-three radiologically evaluated patients comprised 34 molecular-targeted agent (MTA)-naive (first-line), nine intolerant to SOR (second-line), and 10 resistant to regorafenib (third-line). The objective response rates (ORRs) were 61.8% in first-line, 33.3% in second-line, and 20.0% in third-line groups. The overall survival (OS) in the first-line was significantly longer than that in the third-line group (p < 0.05). Patients with better liver functional reserves (child score, ALBI grade) exhibited higher ORR and longer OS. The IC50 of LEN against PLC/PRF5-R2 was significantly higher than that against PLC/PRF5. LEN significantly inhibited more LEN-related signal transduction pathways in PLC/PRF5 than in PLC/PRF5-R2 cells. This suggests that LEN is active and safe as a second/third-line treatment for unresectable HCC. LEN seems more effective for patients with HCC with better hepatic reserve functions or before MTA-resistance is acquired because of the partial cross-resistance to SOR

Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known about a role of AMPAR (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor) in circadian entrainment. Here we show that, in the mouse SCN, GluR2 and GluR4 AMPAR subtypes are abundantly expressed in the retinorecipient area. In vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. In the organotypic SCN slice culture, AMPA application induces phase-dependent phase-shifts of core-clock gene transcription rhythms. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and in vitro, and are consistent with the hypothesis that activation of AMPA receptors is a critical step in the transmission of photic information to the SCN