Nonlinear stochastic biasing from the formation epoch distribution of dark halos

We propose a physical model for nonlinear stochastic biasing of one-point statistics resulting from the formation epoch distribution of dark halos. In contrast to previous works on the basis of extensive numerical simulations, our model provides for the first time an analytic expression for the joint probability function. Specifically we derive the joint probability function of halo and mass density contrasts from the extended Press-Schechter theory. Since this function is derived in the framework of the standard gravitational instability theory assuming the random-Gaussianity of the primordial density field alone, we expect that the basic features of the nonlinear and stochastic biasing predicted from our model are fairly generic. As representative examples, we compute the various biasing parameters in cold dark matter models as a function of a redshift and a smoothing length. Our major findings are (1) the biasing of the variance evolves strongly as redshift while its scale-dependence is generally weak and a simple linear biasing model provides a reasonable approximation roughly at R\simgt 2(1+z)\himpc, and (2) the stochasticity exhibits moderate scale-dependence especially on R\simlt 20\himpc, but is almost independent of $z$. Comparison with the previous numerical simulations shows good agreement with the above behavior, indicating that the nonlinear and stochastic nature of the halo biasing is essentially understood by taking account of the distribution of the halo mass and the formation epoch.Comment: 34 pages, 11 figures, ApJ (2000) in pres

Probing the Core Structure of Dark Halos with Tangential and Radial Arc Statistics

We study the arc statistics of gravitational lensing generated by dark matter halos in order to probe their density profile. We characterize the halo profile by two parameters, the inner slope of the central cusp $\alpha$, and the median amplitude of the concentration parameter, $c_{\rm norm}$, for a halo of mass $10^{14}h^{-1}M_\odot$ at $z=0$, and compute the numbers of tangential and radial arcs produced by gravitational lensing of galaxy clusters. We find that the number of arcs divided by the number of halos is a good statistic which is sensitive to both $c_{\rm norm}$ and $\alpha$ with very weak dependence on the cosmological parameters. If the arc samples with well-defined selection criteria for the clusters become available, one can strongly constrain both $c_{\rm norm}$ and $\alpha$. While our tentative comparison with the existing observational data indicates that the inner density profile of dark halos is indeed as steep as predicted by recent simulations ($\alpha \sim 1.5$), the homogeneous samples of tangential and radial arcs are required for more quantitative discussions.Comment: 23 pages, 8 figures, accepted for publication in Ap

セイカツ シュウカン ト コツソショウショウ : キジャクセイ コッセツ ノ ヨボウ

Osteoporosis is a chronic skeletal condition characterized by impaired bone strength and increased risk of fracture. This disorder causes notable morbidity, deterioration in quality of life （QOL）and mortality in the elderly due to associated with fragility fractures of the spine, hip and wrist. Moreover, the treatment of osteoporotic fractures is also associated with a huge economic cost for society. To avoid the fragility fracture, prevention of osteoporosis and fall down are of great importance. For that purpose, not only pharmacological therapy（mainly by antiresorptive medications） in middle-aged and elderly individuals but also non-pharmacological intervention through lifestyle modification will become important in adolescents and young adults from the early life. Lifestyle modification emphasizing bone health such as adequate calcium, vitamin D and vitamin K nutrition, restriction of caffeine and alcohol consumption, and avoidance of tobacco are essential to the management of osteoporosis risk. Balance and strength training also play important roles in the improvement of bone strength. Most of the risk and preventive factors of osteoporosis are common to those of other lifestylerelated diseases. Therefore, lifestyle modification emphasizing bone health from the early life will contribute to avoid not only fragility fracture but also other lifestyle-related diseases, and will contribute to maintenance or improvement of QOL

Preoperative Butyrylcholinesterase Level as an Independent Predictor of Overall Survival in Clear Cell Renal Cell Carcinoma Patients Treated with Nephrectomy

The prognostic factors for the overall survival (OS) of clear cell renal cell carcinoma (ccRCC) patients treated with nephrectomy are not well defined. In the present study, we investigated the prognostic significance of preoperative butyrylcholinesterase (BChE) levels in 400 ccRCC patients undergoing radical or partial nephrectomy from 1992 to 2013 at our institution. Univariate and multivariate analyses were performed to determine the clinical factors associated with OS. Among the enrolled patients, 302 were diagnosed with organ-confined disease only (T1-2N0M0), 16 with lymph node metastases, and 56 with distant metastases. The median preoperative BChE level was 250 U/L (normal range, 168–470 U/L), and median follow-up period was 36 months. The 3-year OS rate in patients with preoperative BChE levels of ≥100 U/L was significantly higher than in those with levels of <100 U/L (89.3% versus 77.7%, P=0.004). On univariate analysis, performance status; anemia; hypoalbuminemia; preoperative levels of BChE, corrected calcium, and C-reactive protein; and distant metastasis status were significantly associated with OS. Multivariate analysis revealed that preoperative BChE levels and distant metastasis status were significantly associated with OS. Our findings suggest a possible role of preoperative BChE levels as an independent predictor of OS after nephrectomy in ccRCC patients

特別支援教育における発達障害の理解 : 自閉症児の表情認識について

特別支援教育での教育相談や教科教育の活用と見直しを行う場合、発達障害についての特性を知る必要がある. 本研究では他者とのコミュニケーション時に必要とされる表情認識について表情別で行った. 対象は、自閉症群および統制群である. 自閉症児群はDSM-IVの診断基準に該当する高機能自閉症児17名(男性15名、女性2名), 統制群として定型発達児・者12名(男性7名、女性5名)である. 結果は、自閉症の表情認知では全体的な相対的配置よりも顔のそれぞれのパーツにより依存した認知の方法を取っているという結果であった. 表情の主要なパーツ(目・鼻・口)に関して統制群は目を中心に視線を移動しているのに対して、自閉症群は平均した視線移動をしている. これは、Schultzらの報告を支持するものであり、自閉症者・児は顔または表情を1つの物体として捉えていることを示唆している.A purpose of this study went by expression distinction about recognition of facial expression needed at the time of communication with autistic another person. An object is autism group and a group of control. 17 high-performance autism falling under diagnostic criteria of DSM-IV in the autism group(is the fixed form development child / 12 people as control group.) The result was a result to take the method of the recognition dependent on by each part of the face than the general relative placement by the autistic expression recognition. In the control group, the autism group does the eyes movement that I averaged about the main part (eyes/nose/mouth) of the expression whereas I move eyes mainly on eyes. This supports a report of Schultz, and a person of autism / the child suggests that I catch a face or an expression as one object

Active gas features in three HSC-SSP CAMIRA clusters revealed by high angular resolution analysis of MUSTANG-2 SZE and XXL X-ray observations

International audienceWe present results from simultaneous modelling of high angular resolution GBT/MUSTANG-2 90 GHz Sunyaev–Zel’dovich effect (SZE) measurements and XMM-XXL X-ray images of three rich galaxy clusters selected from the HSC-SSP Survey. The combination of high angular resolution SZE and X-ray imaging enables a spatially resolved multicomponent analysis, which is crucial to understand complex distributions of cluster gas properties. The targeted clusters have similar optical richnesses and redshifts, but exhibit different dynamical states in their member galaxy distributions: a single-peaked cluster, a double-peaked cluster, and a cluster belonging to a supercluster. A large-scale residual pattern in both regular Compton-parameter y and X-ray surface brightness distributions is found in the single-peaked cluster, indicating a sloshing mode. The double-peaked cluster shows an X-ray remnant cool core between two SZE peaks associated with galaxy concentrations. The temperatures of the two peaks reach ∼20–30 keV in contrast to the cool core component of ∼2 keV, indicating a violent merger. The main SZE signal for the supercluster is elongated along a direction perpendicular to the major axis of the X-ray core, suggesting a minor merger before core passage. The and y distributions are thus perturbed at some level, regardless of the optical properties. We find that the integrated Compton y parameter and the temperature for the major merger are boosted from those expected by the weak-lensing mass and those for the other two clusters show no significant deviations, which is consistent with predictions of numerical simulations

Use of vonoprazan for management of systemic sclerosis‑related gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) in systemic sclerosis (SSc) can significantly reduce a patient\u27s quality of life. GERD in SSc is occasionally resistant to conventional anti-acid treatment. Vonoprazan is an H+/K+-ATPase blocker that is approved in Japan for treatment of GERD. The aim of the present study was to evaluate the efficacy of vonoprazan in SSc-related GERD. The frequency scale for symptoms of GERD (FSSG) scores were collected before and after vono-prazan treatment in 15 SSc patients with GERD. Additionally, endoscopic esophagogastroduodenoscopy was performed in select patients. Conventional proton pump inhibitors or hista-mine-2 receptor antagonists had been previously administered in 93% (14/15) of the patients. Although the baseline esophago-gastroduodenoscopy examination did not show severe erosion in the majority of patients,the mean total FSSG score before vonoprazan treatment was notably high (25.2±10.7) compared to a normal score of <8. After vonoprazan treatment, the FSSG score decreased to 9.6±7.0. The mean improvement rate of the total FSSG, acid reflux and dysmotility scores were 60.8±21.2% (P=0.0004), 67.3±24.8% (P<0.0001) and 55.4±26.0% (P=0.0022), respectively.These results suggest that vonoprazan may be a potentially effective treatment for GERD in patients with SSc