Oxidative cyclization of thiosemicarbazones with metachloroperbenzoic acid

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Assessment of resistant varieties of maize against Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae) in laboratory conditions

Grains of five different maize varieties (MMRI Yellow, Pearl White, Malka-2016, YH-1898 and Sadaf) were evaluated for their comparative resistance to Tribolium castaneum under laboratory conditions (30+2°C and 70+5 R.H). Data of percent mortality were taken after 30, 60 and 90 days. Significantly, the maximum mortality of adults was observed in MMRI Yellow (28.57%, 33.67% and 41.61%) in sound seeds and lowest mortality was noted in Sadaf (14.88, 21.33% and 24.99%) during observation period. The seed germination was highest in MMRI Yellow which was 90% while lowest was noted in Sadaf as 50%. The highest protein contents were recorded in Malka-2016 (12.83% and 11.60%) and lowest in YH-1898 (3.90% and 2.50%) in both sound and cracked seeds. However, maximum fiber contents were observed in Malka-2106 (2.76% and 2.16%), while lowest (0.43% and 0.30%) in YH-1898 for both seed types. Consequently, MMRI Yellow variety was proved to be resistance as compared to other varieties with maximum germination. It can be concluded that resistant varieties of maize could be utilized in breeding program to reduce the post-harvest losses of grains

Stereoselective synthesis of 1,3-oxazolines by the reaction of steroidal oxiranes with Acetamide

1296-1298The reaction of 3β-acetoxy-5, 6α-epoxy-5α-cholestane 1. 3β-chloro-5<span style="color:#171717; mso-bidi-language:HI">, 6α-epoxy-5α-choles<span style="color:black; mso-bidi-language:HI">tane 2 and 5, 6α-epoxy-5α- choles<span style="color:black; mso-bidi-language:HI">tane 3 with acetamide in THF at room temperature in the presen<span style="color:#171717; mso-bidi-language:HI">ce o<span style="color:black; mso-bidi-language:HI">f LiBr as cataly<span style="color:#171717; mso-bidi-language:HI">st afford selectively <span style="color:black; mso-bidi-language:HI">the corresponding s<span style="color:black; mso-bidi-language:HI">ter<span style="color:#171717;mso-bidi-language: HI">oidal, <span style="color:#171717; mso-bidi-language:HI">c<span style="color:black;mso-bidi-language: HI">is-1,3-oxazolines <span style="color:black; mso-bidi-language:HI">4-6<span style="color:black;mso-bidi-language: HI"> in high yield<span style="color:#171717; mso-bidi-language:HI">s. The structures of th<span style="color:#171717; mso-bidi-language:HI">ese compounds 4-6 have bee<span style="color:black; mso-bidi-language:HI">n <span style="color:#171717;mso-bidi-language: HI">esta<span style="color:black; mso-bidi-language:HI">bli<span style="color:#171717;mso-bidi-language: HI">she<span style="color:black; mso-bidi-language:HI">d on the basis of their <span style="color:#171717; mso-bidi-language:HI">ele<span style="color:black; mso-bidi-language:HI">m<span style="color:#171717;mso-bidi-language: HI">ental analys<span style="color:black; mso-bidi-language:HI">e<span style="color:#171717;mso-bidi-language: HI">s and s<span style="color:black; mso-bidi-language:HI">pectral data. </span

Stereoselective Formation of Steroidal (6R)-Spiro Oxazolidines.

2866-2868The reaction of steroidal 6-ketones 1-3 with R(-)-2-amino butanol in the presence of p-TsOH as catalyst affords selectively the respective steroidal (6R)-spiro-4'-ethyl-1',3'-oxazolidines 4-6 respectively in good yields. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data.

Stereoselective formation of steroidal (6<i>R</i>)-spiro oxazolidines

2866-2868The reaction of steroidal 6-ketones 1-3 with R(-)-2-amino butanol in the presence of p-TsOH as catalyst affords selectively the respective steroidal (6R)-spiro-4'-ethyl-1',3'-oxazolidines 4-6 respectively in good yields. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data.

Stereoselective synthesis of substituted steroidal 1,3-oxathiolanes

2676-2678The reactions of 5,6 α-epoxy-5α-cholestane 1, 3β-acetoxy-5,6α-epoxy-5α-cholestane 2 and 3 β-chloro-5,6α-epoxy-5α cholestane 3 with thioacetamide in THF at room temperature in the presence of LiBr as a catalyst afford selectively the corresponding substituted steroidal 1,3-oxathiolanes 4-6 in high yields. The structures of these compounds have been established on the oasis of their elemental, analytical and spectral data

Synthesis and biological evaluation of new oxime-ether derivatives of steroid as anti-bacterial agents

AbstractVarious oxime-ether derivatives of cholesterol have been synthesized by the alkylation of the steroidal oxime with 1-(2-chloroethyl) pyrrolidine hydrogen chloride/chloroethylamine hydrochloride in the presence of sodium methoxide in dry methanol. The structures of these compounds were elucidated by IR 1H NMR, FAB mass spectroscopic methods and elemental analyses. The anti-bacterial activity was first tested in vitro by the disk diffusion method against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of compounds were determined. The results showed that the chloro derivatives exhibited better anti-bacterial activity than the standard drug chloramphenicol

Synthesis of new steroidal oxazoles and thiazoles

2872-2874The reaction of 5α-bromocholestan-6-one 1, its 3β-acetoxy 2 and 3β-chloro 3 analogues with urea and thiourea, separately, in ethanol under reflux affords 2'-amino-5α-cholest-6-eno [6,5-d] oxazole 4, 3β-acetoxy-2'-amino-5α-cholest-6-eno [6,5–d] oxazole 5, 3β-chloro-2'-amino-5α-cholest-6-eno [6,5-d] oxazole 6, 2'-amino-5α-cholest-6-eno [6,5-d] thiazole 7, 3β- acetoxy-2'-amino-5α-cholest-6-eno [6,5-d] thiazole 8, 3β-chloro-2'-amino-5α-cholest- 6-eno [6,5-d] thiazole 9, respectively. The structures of the products have been established on the basis of their chemical analytical and spectral analysis. &nbsp

Simultaneous HPTLC determination of strychnine and brucine in strychnos nux-vomica seed

Objective: A simple, sensitive, and specific thin layer chromatography (TLC) densitometry method has been developed for the simultaneous quantification of strychnine and brucine in the seeds of Strychnos nux-vomica. Materials and Methods: The method involved simultaneous estimation of strychnine and brucine after resolving it by high performance TLC (HPTLC) on silica gel plate with chloroform-methanol-formic acid (8.5:1.5:0.4 v/v/v) as the mobile phase. Results: The method was validated as per the ICH guidelines for precision (interday, intraday, intersystem), robustness, accuracy, limit of detection, and limit of quantitation. The relationship between the concentration of standard solutions and the peak response was linear within the concentration range of 50-1000 ng/spot for strychnine and 100-1000 ng/spot for brucine. The method precision was found to be 0.58-2.47 (% relative standard deviation [RSD]) and 0.36-2.22 (% RSD) for strychnine and brucine, respectively. Accuracy of the method was checked by recovery studies conducted at three different concentration levels and the average percentage recovery was found to be 100.75% for strychnine and 100.52% for brucine, respectively. Conclusions: The HPTLC method for the simultaneous quantification of strychnine and brucine was found to be simple, precise, specific, sensitive, and accurate and can be used for routine analysis and quality control of raw material of S. nux-vomica and several unani and ayurvedic formulations containing this as an ingredient