Stereoselective formation of steroidal (6<i>R</i>)-spiro oxazolidines

Abstract

2866-2868The reaction of steroidal 6-ketones 1-3 with R(-)-2-amino butanol in the presence of p-TsOH as catalyst affords selectively the respective steroidal (6R)-spiro-4'-ethyl-1',3'-oxazolidines 4-6 respectively in good yields. The structures of these compounds have been established on the basis of their elemental, analytical and spectral data.