Change in stability of solid solution at radiation influence

Stability of solid solution at radiation influence has been investigated. Expressions for diffusion streams of binary alloy components, which specify the existence of temperature interval in which the phenomenon of ascending diffusion of elements is observed, were received. Vacancy characters of diffusion, configuration entropy, and potential energy of atomic bonds were considered at derivation. The ascending diffusion testifies to stability infringement of homogeneous solid solution - stratification. Influence of radiation is connected with increase in concentration of vacancies which changes the energy of atomic bonds and, simultaneously, accelerates diffusion processes. The condition of alloy stability with regard to stratification at radiating influence was obtaine

Causeplay a documentary on why Filipino cosplayers engage in cosplay (costume play) and its possible relation to escapism

This study aims to understand why cosplayers engage in cosplay by examining both their private and cosplay lives. Cosplay is associated with bringing fantasy to life. Many cosplayers come from marginalized groups, and are usually perceived as nerds and geeks. Fantasy thus offers a form of escape which allows cosplayers reveal representation of who they want to be. Dissatisfaction with one\u27s true self would be compensated by one\u27s projected visual representation, but in some cases, it results to a stronger self-image (Bonnchsen 51 Casey 25, 26, 46 Hsao-ping Chen 72,73,73,74 Nesic 85)

Creating Accessible and Inclusive Online Learning: Moving Beyond Compliance and Broadening the Discussion

Accessibility is a hot topic in online education these days. Despite the increased focus on accessibility, most discussions of creating accessible online courses and elearning simply focus on adding alternative text to images and captions to video. In this article, we argue that online educators and workplace learning professionals (including instructors, instructional designers, managers, and administrators) should be thinking beyond compliance and instead thinking about how they can support all learners. We begin by providing the overview of some laws focused on accessibility, we then describe how people struggle learning online at all levels (i.e., compulsory, postsecondary, and workplaces), and then conclude with evidence-based practices on how online educators and workplace learning professionals can support all learners

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury

Abstract Ductular reactive (DR) cells exacerbate cholestatic liver injury and fibrosis. Herein, we posit that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) emanates from recruited macrophages and restrains DR cell expansion, thereby limiting cholestatic liver injury. Wild type (WT), Trail fl/fl and myeloid-specific Trail deleted (Trail Δmye ) C57BL/6 mice were exposed to DDC diet-induced cholestatic liver injury, which induced hepatomegaly and liver injury as compared to control diet-fed mice. However, parameters of liver injury, fibrosis, and inflammation were all increased in the Trail Δmye mice as compared to the WT and Trail fl/fl mice. High dimensional mass cytometry indicated that cholestasis resulted in increased hepatic recruitment of subsets of macrophages and neutrophils in the Trail Δmye mice. Spatial transcriptomics analysis revealed that the PanCK+ cholangiocytes from Trail Δmye mice had increased expression of the known myeloid attractants S100a8, Cxcl5, Cx3cl1, and Cxcl1. Additionally, in situ hybridization of Cxcl1, a potent neutrophil chemoattractant, demonstrated an increased expression in CK19+ cholangiocytes of Trail Δmye mice. Collectively, these data suggest that TRAIL from myeloid cells, particularly macrophages, restrains a subset of DR cells (i.e., Cxcl1 positive cells), limiting liver inflammation and fibrosis. Reprogramming macrophages to express TRAIL may be salutary in cholestasis

Scientific Societies Fostering Inclusive Scientific Environments through Travel Awards: Current Practices and Recommendations

Diversity-focused committees continue to play essential roles in the efforts of professional scientific societies to foster inclusion and facilitate the professional development of underrepresented minority (URM) young scientists in their respective scientific disciplines. Until recently, the efforts of these committees have remained independent and disconnected from one another. Funding from the National Science Foundation has allowed several of these committees to come together and form the Alliance to Catalyze Change for Equity in STEM Success, herein referred to as ACCESS. The overall goal of this meta-organization is to create a community in which diversity-focused committees can interact, synergize, share their collective experiences, and have a unified voice on behalf of URM trainees in science, technology, engineering, and mathematics disciplines. In this Essay, we compare and contrast the broad approaches that scientific societies in ACCESS use to implement and assess their travel award programs for URM trainees. We also report a set of recommendations, including both short- and long-term outcomes assessment in populations of interest and specialized programmatic activities coupled to travel award programs

Scientific Societies Fostering Inclusivity through Speaker Diversity in Annual Meeting Programming: A Call to Action

Scientific societies aiming to foster inclusion of scientists from underrepresented (UR) backgrounds among their membership often delegate primary responsibility for this goal to a diversity-focused committee. The National Science Foundation has funded the creation of the Alliance to Catalyze Change for Equity in STEM Success (ACCESS), a meta-organization bringing together representatives from several such STEM society committees to serve as a hub for a growing Community of Practice. Its goal is to coordinate efforts to advance inclusive practices by sharing experiences and making synergistic discoveries about what works. ACCESS has analyzed the approaches by which member societies have sought to ensure inclusivity through selection of annual meeting speakers. Not only do we discuss how inclusive speaker selection fosters better scientific environments for all, but also identify challenges and promising practices for societies striving to maximize inclusivity of speakers in their scientific programming